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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Periapical Tissue

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Disease relevance of Periapical Tissue


High impact information on Periapical Tissue


Biological context of Periapical Tissue

  • These results indicate that proinflammatory cytokines can induce t-PA gene expression and such an effect may partially contribute to the destruction of pulpal and periapical tissues through dysregulated pericellular proteolysis [9].

Anatomical context of Periapical Tissue


Associations of Periapical Tissue with chemical compounds


Gene context of Periapical Tissue

  • CONCLUSIONS: The findings demonstrate the presence of MMP-8 in the inflamed pulp and periapical tissue, indicating that MMP-8 has a role in pulpal and periapical inflammation, most likely participating in tissue extracellular matrix degradation [16].
  • Cells that express interleukin-1 alpha were identified in pulp beginning on day 2 after exposure and in periapical tissue beginning on day 7, as determined by in situ hybridization and immunostaining [17].
  • Obturated and unfilled canal space and the status of periapical tissues were evaluated according to the PAI index [18].
  • These results demonstrated that in human periapical tissue cytokines differentially and specifically regulate expression of TIMP-1 mRNA [19].
  • OBJECTIVE: The purpose of this study was to quantify the cytokines interleukin (IL)-1 receptor antagonist (RA), IL-6, and transforming growth factor beta(1) found in extracts of inflammatory periapical tissues and to study the effect of a new antibiotic (linezolid) on the levels of these cytokines [20].

Analytical, diagnostic and therapeutic context of Periapical Tissue


  1. Histological and histochemical study of the influence of lipopolysaccharide extracted from Fusobacterium nucleatum on the periapical tissues in the monkey Macaca fascicularis. Dahlén, G., Magnusson, B.C., Möller, A. Arch. Oral Biol. (1981) [Pubmed]
  2. Tumor necrosis factor identified in periapical tissue exudates of teeth with apical periodontitis. Safavi, K.E., Rossomando, E.F. Journal of endodontics. (1991) [Pubmed]
  3. Induction of interleukin-8 gene expression by black-pigmented Bacteroides in human pulp fibroblasts and osteoblasts. Yang, L.C., Huang, F.M., Lin, C.S., Liu, C.M., Lai, C.C., Chang, Y.C. International endodontic journal. (2003) [Pubmed]
  4. Cytokine regulation on the synthesis of nitric oxide in vivo by chronically infected human polymorphonuclear leucocytes. Takeichi, O., Saito, I., Okamoto, Y., Tsurumachi, T., Saito, T. Immunology (1998) [Pubmed]
  5. Tissue response following CO2 laser application in apical surgery: light microscopic assessment in dogs. Friedman, S., Rotstein, I., Bab, I. Lasers in surgery and medicine. (1992) [Pubmed]
  6. Cytomegalovirus and Epstein-Barr virus DNA transcription in endodontic symptomatic lesions. Sabeti, M., Valles, Y., Nowzari, H., Simon, J.H., Kermani-Arab, V., Slots, J. Oral Microbiol. Immunol. (2003) [Pubmed]
  7. Role of IL-2 and helper T-lymphocytes in limiting periapical pathosis. Yamasaki, M., Morimoto, T., Tsuji, M., Akihiro, I., Maekawa, Y., Nakamura, H. Journal of endodontics. (2006) [Pubmed]
  8. An in vitro study of coronal leakage after intraradicular preparation of cast-dowel space. Pappen, A.F., Bravo, M., Gonzalez-Lopez, S., Gonzalez-Rodriguez, M.P. The Journal of prosthetic dentistry. (2005) [Pubmed]
  9. Induction of tissue plasminogen activator gene expression by proinflammatory cytokines in human pulp and gingival fibroblasts. Chang, Y.C., Yang, S.F., Huang, F.M., Tai, K.W., Hsieh, Y.S. Journal of endodontics. (2003) [Pubmed]
  10. Healing process of dog teeth after post space preparation and exposition of the filling material to the oral environment. Barbosa, H.G., Holland, R., de Souza, V., Dezan, E.J., Bernabé, P.F., Otoboni, J.A., Nery, M.J. Brazilian dental journal. (2003) [Pubmed]
  11. Periapical lesions accidentally filled with calcium hydroxide. De Moor, R.J., De Witte, A.M. International endodontic journal. (2002) [Pubmed]
  12. Sodium hypochlorite injection into periapical tissues. Cymbler, D.M., Ardakani, P. Dental update. (1994) [Pubmed]
  13. Anti-inflammatory effects of dexamethasone on periapical tissues following endodontic overinstrumentation. Nobuhara, W.K., Carnes, D.L., Gilles, J.A. Journal of endodontics. (1993) [Pubmed]
  14. Changes in CGRP-immunoreactive nerve fibres during experimental tooth movement in rats. Kvinnsland, I., Kvinnsland, S. European journal of orthodontics. (1990) [Pubmed]
  15. Cytomegalovirus and Epstein-Barr virus active infection in periapical lesions of teeth with intact crowns. Sabeti, M., Simon, J.H., Nowzari, H., Slots, J. Journal of endodontics. (2003) [Pubmed]
  16. Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates. Wahlgren, J., Salo, T., Teronen, O., Luoto, H., Sorsa, T., Tjäderhane, L. International endodontic journal. (2002) [Pubmed]
  17. Pathogenesis of induced rat periapical lesions. Stashenko, P., Wang, C.Y., Tani-Ishii, N., Yu, S.M. Oral Surg. Oral Med. Oral Pathol. (1994) [Pubmed]
  18. Postoperative pain after endodontic retreatment: single- versus two-visit treatment. Yoldas, O., Topuz, A., Isçi, A.S., Oztunc, H. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2004) [Pubmed]
  19. Regulation of tissue inhibitors of metalloproteinase-1 gene expression by cytokines in human gingival fibroblasts. Yang, Y.Y., Tsai, H.F., Lu, S.C., Huang, Y.F., Chang, Y.C. Journal of endodontics. (2002) [Pubmed]
  20. Cytokines in periradicular lesions: the effect of linezolid treatment. Danin, J., Linder, L., Lundqvist, G., Wretlind, B. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2003) [Pubmed]
  21. Coexpression of vasoactive intestinal polypeptide and substance P in reinnervating pulpal nerves and in trigeminal ganglion neurones after axotomy of the inferior alveolar nerve in the rat. Fristad, I., Jacobsen, E.B., Kvinnsland, I.H. Arch. Oral Biol. (1998) [Pubmed]
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