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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Laboratory Personnel

 
 
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Disease relevance of Laboratory Personnel

 

High impact information on Laboratory Personnel

  • More than 50% of the 459 cancer sera showed a high inhibition of 125I-Clq uptake by sensitized sheep erythrocytes when compared with sera of 50 healthy laboratory personnel [6].
  • To investigate this, 2% erythromycin or vehicle was applied to each subject's forehead (n = 225) twice a day by laboratory personnel for a period of 6 weeks [7].
  • Thus, the assembly of four of the groups essential to the transplant process--clinicians, laboratory scientists, the pharmaceutical company, and the manufacturers of cyclosporine measurement kits--provided a unique opportunity to evaluate therapeutic drug monitoring issues facing the transplant field [8].
  • A concise set of procedures is presented to aid laboratory personnel in complying with Part 20.205 of Title 10, Chapter 1, of the Code of Federal Regulations, concerning the receipt and monitoring of radioactive materials [9].
  • However, mercuric chloride is potentially hazardous to laboratory personnel and presents disposal problems [10].
 

Chemical compound and disease context of Laboratory Personnel

 

Anatomical context of Laboratory Personnel

 

Associations of Laboratory Personnel with chemical compounds

  • Sera from 15 healthy laboratory technicians contained total lactate dehydrogenase, isoenzymes 1 and 2, and isoenzymes 3, 4, and 5 in the ranges 94 to 152, 34 to 64, and 38 to 75 U/liter, respectively [17].
  • In the peripheral blood PMNLs of healthy laboratory personnel, the rate of incorporation of L-[35S]methionine into a least nine polypeptides was consistently influenced by dexamethasone in a dose-dependent manner, being increased in the case of seven polypeptides and decreased in the remainder [18].
  • In addition to economy from a decrease in personnel handling time and from purchasing formaldehyde in bulk, it decreases the exposure of laboratory personnel to formaldehyde fumes [19].
  • Only by clearly understanding these pathophysiological interrelationships can the clinician and laboratory scientist appreciate the divergent and wide spectrum of often confusing clinical and laboratory findings in patients with DIC [20].
  • Fecal steroid analyses are becoming more popular among both field and laboratory scientists [21].
 

Gene context of Laboratory Personnel

  • The results of this survey were extremely valuable to ASMT during recent federal regulatory and legal proceedings regarding the role of clinical laboratory scientists in laboratory services delivery and medicare payment policy for hospital clinical laboratory services [22].
  • To find out whether IgG genes are involved in atopy we studied 26 of 101 laboratory technicians who had developed laboratory animal allergy (LAA) [23].
  • METHODS AND MATERIALS: ABPI was measured in six patients with various degrees of PAOD by two experienced observers (vascular laboratory assistants) and by 24 less-experienced observers (18 practice assistants, six GPs) [24].
  • BACKGROUND: Rat bite fever is a zoonotic disease that has been described in laboratory personnel as well as the general population [25].
  • The "most probable number" (MPN) technique for estimating numbers of bacteria in suspensions is well known and has been used for decades by microbiologists, food researchers, and other laboratory scientists [26].
 

Analytical, diagnostic and therapeutic context of Laboratory Personnel

  • Eighty-five percent of laboratory personnel working with staphylococcal enterotoxin had antibodies to enterotoxin in their sera, whereas only 23% of the control group had antibodies specific for enterotoxin [27].
  • When PCR technique is performed by experienced laboratory personnel using controlled protocols, false-negative (caused primarily by endogenous polymerase inhibitors) and false-positive results (due to contamination) can generally be avoided, achieving sensitivity and specificity close to 100% [28].

References

  1. Separation of tissue and serum acid phosphatase isoenzymes by ion-exchange column chromatography. Mercer, D.W. Clin. Chem. (1977) [Pubmed]
  2. The immunodominance of epitopes within the transmembrane protein (gp41) of human immunodeficiency virus type 1 may be determined by the host's previous exposure to similar epitopes on unrelated antigens. Davis, D., Chaudhri, B., Stephens, D.M., Carne, C.A., Willers, C., Lachmann, P.J. J. Gen. Virol. (1990) [Pubmed]
  3. Molecular methods for detecting t(11;14) translocations in mantle-cell lymphomas. Fan, H., Gulley, M.L., Gascoyne, R.D., Horsman, D.E., Adomat, S.A., Cho, C.G. Diagn. Mol. Pathol. (1998) [Pubmed]
  4. Allergic contact dermatitis from d-limonene in a laboratory technician. Wakelin, S.H., McFadden, J.P., Leonard, J.N., Rycroft, R.J. Contact Derm. (1998) [Pubmed]
  5. Allergic contact dermatitis from phenoxybenzamine hydrochloride: cross-sensitivity to some related haloalkylamine compounds. Mitchell, J.C., Maibach, H.I. Contact Derm. (1975) [Pubmed]
  6. Circulating immune complexes detected by 125I-Clq deviation test in sera of cancer patients. Teshima, H., Wanebo, H., Pinsky, C., Day, N.K. J. Clin. Invest. (1977) [Pubmed]
  7. Effects of topical erythromycin on ecology of aerobic cutaneous bacterial flora. Vowels, B.R., Feingold, D.S., Sloughfy, C., Foglia, A.N., Konnikov, N., Ordoukhanian, E., Starkey, P., Leyden, J.J. Antimicrob. Agents Chemother. (1996) [Pubmed]
  8. Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine. Kahan, B.D., Shaw, L.M., Holt, D., Grevel, J., Johnston, A. Clin. Chem. (1990) [Pubmed]
  9. Procedures for receiving and opening packages containing radioactivity. LeBlanc, A.D., Johnson, P.C. J. Nucl. Med. (1976) [Pubmed]
  10. Comparison of polyvinyl alcohol fixative with three less hazardous fixatives for detection and identification of intestinal parasites. Jensen, B., Kepley, W., Guarner, J., Anderson, K., Anderson, D., Clairmont, J., De L'aune, W., Austin, E.H., Austin, G.E. J. Clin. Microbiol. (2000) [Pubmed]
  11. Allergic contact dermatitis from laboratory synthesis of 4-bromomethyl-6,8-dimethyl-2(1H)-quinolone. Rycroft, R.J. Contact Derm. (1981) [Pubmed]
  12. Contact allergy to propylene oxide and isopropyl alcohol in a skin disinfectant swab. Jensen, O. Contact Derm. (1981) [Pubmed]
  13. Occupational rhinitis and asthma to latex. Moneret-Vautrin, D.A., Debra, J.C., Kohler, C., Stringini, R., Kanny, G., Guillaumot, A., Buthmann, D. Rhinology. (1994) [Pubmed]
  14. Allergy caused by light-cured ear-moulds. Koefoed-Nielsen, B., Pedersen, B. Scandinavian audiology. (1993) [Pubmed]
  15. Allergic contact dermatitis to epoxy resin in microscopy immersion oil: cases from Canada. Sasseville, D., Moreau, L., Brassard, J., Leclerc, G. Am. J. Contact Dermatitis (2000) [Pubmed]
  16. Emergency physicians versus laboratory technicians: are the urinalysis and microscopy results comparable? A pilot study. Kerr, S., Marshall, C., Sinclair, D. The Journal of emergency medicine. (1999) [Pubmed]
  17. Simultaneous separation of serum creatine kinase and lactate dehydrogenase isoenzymes by ion-exchange column chromatography. Mercer, D.W. Clin. Chem. (1975) [Pubmed]
  18. Effect of dexamethasone on polypeptides synthesised in polymorphonuclear leucocytes. Blowers, L.E., Jayson, M.I., Jasani, M.K. FEBS Lett. (1985) [Pubmed]
  19. An automated system for the handling, diluting, and dispensing of formaldehyde. Lupovitch, A., LePage, D. Am. J. Clin. Pathol. (1981) [Pubmed]
  20. Disseminated intravascular coagulation. Objective criteria for diagnosis and management. Bick, R.L. Med. Clin. North Am. (1994) [Pubmed]
  21. Lake pigments facilitate analysis of fecal cortisol and behavior in group-housed macaques. Stavisky, R.C., Whitten, P.L., Hammett, D.H., Kaplan, J.R. Am. J. Phys. Anthropol. (2001) [Pubmed]
  22. Comparing nonphysician and physician laboratory administrative responsibilities. Barr, J.T. The American journal of medical technology. (1983) [Pubmed]
  23. Development of allergy to laboratory animals is associated with particular Gm and HLA genes. Oxelius, V.A., Sjöstedt, L., Willers, S., Löw, B. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  24. The influence of experience on the reproducibility of the ankle-brachial systolic pressure ratio in peripheral arterial occlusive disease. Kaiser, V., Kester, A.D., Stoffers, H.E., Kitslaar, P.J., Knottnerus, J.A. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (1999) [Pubmed]
  25. Fatal rat bite fever in a pet shop employee. Shvartsblat, S., Kochie, M., Harber, P., Howard, J. Am. J. Ind. Med. (2004) [Pubmed]
  26. Estimation of the thermal coefficient in the decline of a bacterial population under heat stress. Wiggins, A.D. Mathematical biosciences. (1991) [Pubmed]
  27. Antibodies to staphylococcal enterotoxin in laboratory personnel. Jozefczyk, Z., Robbins, R.N., Spitz, J.M., Bergdoll, M.S. J. Clin. Microbiol. (1980) [Pubmed]
  28. Molecular diagnosis of tuberculosis. Richeldi, L., Barnini, S., Saltini, C. The European respiratory journal. Supplement. (1995) [Pubmed]
 
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