Disease relevance of Serositis

• Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis [1].
• Manifestations of SLE such as fatigue, arthralgia/arthritis, and serositis responded particularly well to this protocol [2].
• CONCLUSION: Chinese SLE patients are far less likely to have serositis or a hematologic disorder at diagnosis and may be more likely to develop proteinuria or CNS or other major organ involvement over the course of the disease, compared with Caucasian SLE patients [3].
• It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms [4].
• Familial Mediterranean fever (FMF) is a genetic disease characterized by painful febrile "attacks" of serositis and the development of amyloidosis [5].

High impact information on Serositis

• Physical and chemical irritation of the peritoneum through glucose-based hyperosmolar dialysis solutions results in a nonbacterial serositis with fibrinous exudation [6].
• During serositis, activated MC, both sessile and detached, expressed an extended spectrum of beta1, beta3 and beta4 integrins compared with resting MC, as shown by immunohistology [7].
• CONCLUSION: In this series, serositis and cutaneous vasculitis were predominant extra-articular manifestations of RA; and mortality was greater in the ExRA than in the non-ExRA subgroup, perhaps due to a high frequency of associated heart disease [8].
• Arthritis was less common as a first symptom in the men, although this group of patients had discoid lesions and serositis more often than the women [9].
• Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurring attacks of fever and serositis [10].

Chemical compound and disease context of Serositis

• RESULTS: Addition of Ursodiol to high-dose IBU and normal doses of PE showed a significant reduction in the percentage of rats with ulcers (P < 0.05), total number of serositis events (P < 0.01), total number of severe ulcers (P < 0.001), and an absence of ulcers in the large intestine [11].
• Moderate to high doses of oral prednisolone was used in 28 (76%) patients for both serositis and concomitant disease activity in other organs [12].
• 6-Sulfanilamidoindazole (6SAI) is known to induce not only an acute arthritis but also serositis and arteritis which resemble those induced by some vasodilators in rats [13].
• In particular, positive correlations were found between IIF ANCA and serositis (p = 0.026), livedo reticularis (p = 0.01), venous thrombosis (p = 0.03) and arthritis (p = 0.04), while anti-LF antibodies were associated with serositis (p = 0.05) and livedo reticularis (p < 10(-3) [14].
• Although most of the toxic effects of moderate-dose GMCSF are controlled by antihistamines and ibuprofen, oral glucocorticoids (e.g., prednisone, 10 mg twice daily during the second week of GMCSF administration) may be required in patients with serositis, pulmonary infiltrates, or severe skin eruptions [15].

Biological context of Serositis

• Here, we report a Japanese female FMF patient with heterozygosity for the compound pyrin E148Q/M694I showing recurrent fever, serositis or delay in skin wound healing [16].

Anatomical context of Serositis

• New-onset lupus presenting as serositis in an 80-year-old woman: does a high-titer ANA in pleural, pericardial, or peritoneal fluid help confirm the diagnosis [17]?

Gene context of Serositis

• BACKGROUND: Familial Mediterranean fever (FMF) is a periodic febrile disorder, characterised by fever and serositis [18].
• A significant association between serositis and the presence of BPI-, LF-, and PR3-ANCA was observed, and PR3-ANCA were found to be associated with arthritis as well [19].
• Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis [20].
• There were no significant differences between RA patients and groups A and B. Serum ferritin was elevated especially in serositis and hematologic manifestation [21].
• In this subgroup serositis as well as elevated concentrations of CRP were observed more frequently (P less than 0.02) [22].

References