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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Serositis


High impact information on Serositis

  • Physical and chemical irritation of the peritoneum through glucose-based hyperosmolar dialysis solutions results in a nonbacterial serositis with fibrinous exudation [6].
  • During serositis, activated MC, both sessile and detached, expressed an extended spectrum of beta1, beta3 and beta4 integrins compared with resting MC, as shown by immunohistology [7].
  • CONCLUSION: In this series, serositis and cutaneous vasculitis were predominant extra-articular manifestations of RA; and mortality was greater in the ExRA than in the non-ExRA subgroup, perhaps due to a high frequency of associated heart disease [8].
  • Arthritis was less common as a first symptom in the men, although this group of patients had discoid lesions and serositis more often than the women [9].
  • Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurring attacks of fever and serositis [10].

Chemical compound and disease context of Serositis

  • RESULTS: Addition of Ursodiol to high-dose IBU and normal doses of PE showed a significant reduction in the percentage of rats with ulcers (P < 0.05), total number of serositis events (P < 0.01), total number of severe ulcers (P < 0.001), and an absence of ulcers in the large intestine [11].
  • Moderate to high doses of oral prednisolone was used in 28 (76%) patients for both serositis and concomitant disease activity in other organs [12].
  • 6-Sulfanilamidoindazole (6SAI) is known to induce not only an acute arthritis but also serositis and arteritis which resemble those induced by some vasodilators in rats [13].
  • In particular, positive correlations were found between IIF ANCA and serositis (p = 0.026), livedo reticularis (p = 0.01), venous thrombosis (p = 0.03) and arthritis (p = 0.04), while anti-LF antibodies were associated with serositis (p = 0.05) and livedo reticularis (p < 10(-3) [14].
  • Although most of the toxic effects of moderate-dose GMCSF are controlled by antihistamines and ibuprofen, oral glucocorticoids (e.g., prednisone, 10 mg twice daily during the second week of GMCSF administration) may be required in patients with serositis, pulmonary infiltrates, or severe skin eruptions [15].

Biological context of Serositis

  • Here, we report a Japanese female FMF patient with heterozygosity for the compound pyrin E148Q/M694I showing recurrent fever, serositis or delay in skin wound healing [16].

Anatomical context of Serositis


Gene context of Serositis

  • BACKGROUND: Familial Mediterranean fever (FMF) is a periodic febrile disorder, characterised by fever and serositis [18].
  • A significant association between serositis and the presence of BPI-, LF-, and PR3-ANCA was observed, and PR3-ANCA were found to be associated with arthritis as well [19].
  • Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis [20].
  • There were no significant differences between RA patients and groups A and B. Serum ferritin was elevated especially in serositis and hematologic manifestation [21].
  • In this subgroup serositis as well as elevated concentrations of CRP were observed more frequently (P less than 0.02) [22].


  1. Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population. Aksentijevich, I., Torosyan, Y., Samuels, J., Centola, M., Pras, E., Chae, J.J., Oddoux, C., Wood, G., Azzaro, M.P., Palumbo, G., Giustolisi, R., Pras, M., Ostrer, H., Kastner, D.L. Am. J. Hum. Genet. (1999) [Pubmed]
  2. An open study of B lymphocyte depletion in systemic lupus erythematosus. Leandro, M.J., Edwards, J.C., Cambridge, G., Ehrenstein, M.R., Isenberg, D.A. Arthritis Rheum. (2002) [Pubmed]
  3. A comparative study of the clinical manifestations of systemic lupus erythematosus in Caucasians in Rochester, Minnesota, and Chinese in Singapore, from 1980 to 1992. Thumboo, J., Uramoto, K., O'Fallon, W.M., Fong, K.Y., Boey, M.L., Feng, P.H., Thio, S.T., Gabriel, S.E., Chng, H.H., Howe, H.S., Koh, E.T., Koh, W.H., Leong, K.H., Leong, K.P. Arthritis Rheum. (2001) [Pubmed]
  4. Sulfasalazine-induced lupus erythematosus. Clementz, G.L., Dolin, B.J. Am. J. Med. (1988) [Pubmed]
  5. The changing face of familial Mediterranean fever. Livneh, A., Langevitz, P., Zemer, D., Padeh, S., Migdal, A., Sohar, E., Pras, M. Semin. Arthritis Rheum. (1996) [Pubmed]
  6. D-glucose increases the synthesis of tissue-type plasminogen activator (t-PA) in human peritoneal mesothelial cells. Sitter, T., Mandl-Weber, S., Wörnle, M., Haslinger, B., Goedde, M., Kooistra, T. Thromb. Haemost. (1999) [Pubmed]
  7. Pleural mesothelioma mimics the integrin profile of activated, sessile rather than detached mesothelial cells. Barth, T.F., Brüderlein, S., Rinaldi, N., Mechtersheimer, G., Möller, P. Int. J. Cancer (1997) [Pubmed]
  8. Extra-articular rheumatoid arthritis: prevalence and mortality. Turesson, C., Jacobsson, L., Bergström, U. Rheumatology (Oxford, England) (1999) [Pubmed]
  9. Systemic lupus erythematosus in men: clinical and immunological characteristics. Font, J., Cervera, R., Navarro, M., Pallarés, L., López-Soto, A., Vivancos, J., Ingelmo, M. Ann. Rheum. Dis. (1992) [Pubmed]
  10. Familial Mediterranean fever: the segregation of four different mutations in 13 individuals from one inbred family: genotype-phenotype correlation and intrafamilial variability. Gershoni-Baruch, R., Shinawi, M., Shamaly, H., Katsinetz, L., Brik, R. Am. J. Med. Genet. (2002) [Pubmed]
  11. Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat. Lloyd-Still, J.D., Beno, D.W., Uhing, M.R., Jiyamapa-Serna, V.A., Kimura, R.E. J. Pediatr. Gastroenterol. Nutr. (2001) [Pubmed]
  12. Serositis related to systemic lupus erythematosus: prevalence and outcome. Man, B.L., Mok, C.C. Lupus (2005) [Pubmed]
  13. Recovery process of arthritis induced by 6-sulfanilamidoindazole (6SAI) in rats. Ohmachi, Y., Fujimura, H., Otsuka, E., Miyazaki, T., Toriumi, W., Kitamura, K., Doi, K. Histol. Histopathol. (2002) [Pubmed]
  14. Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE. Galeazzi, M., Morozzi, G., Sebastiani, G.D., Bellisai, F., Marcolongo, R., Cervera, R., De Ramòn Garrido, E., Fernandez-Nebro, A., Houssiau, F., Jedryka-Goral, A., Mathieu, A., Papasteriades, C., Piette, J.C., Scorza, R., Smolen, J. Clinical and experimental rheumatology. (1998) [Pubmed]
  15. Granulocyte-macrophage colony-stimulating factor. Preliminary observations on the influences of dose, schedule, and route of administration in patients receiving cyclophosphamide and carboplatin. Edmonson, J.H., Hartmann, L.C., Long, H.J., Colon-Otero, G., Fitch, T.R., Jefferies, J.A., Braich, T.A., Maples, W.J. Cancer (1992) [Pubmed]
  16. A Japanese patient with familial Mediterranean fever associated with compound heterozygosity for pyrin variant E148Q/M694I. Nakamura, A., Yazaki, M., Tokuda, T., Hattori, T., Ikeda, S. Intern. Med. (2005) [Pubmed]
  17. New-onset lupus presenting as serositis in an 80-year-old woman: does a high-titer ANA in pleural, pericardial, or peritoneal fluid help confirm the diagnosis? Trock, D., Voinea, A., Wolk, J., Majoros, S. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. (2005) [Pubmed]
  18. Specific glycosylation of alpha(1)-acid glycoprotein characterises patients with familial Mediterranean fever and obligatory carriers of MEFV. Poland, D.C., Drenth, J.P., Rabinovitz, E., Livneh, A., Bijzet, J., van het Hof, B., van Dijk, W. Ann. Rheum. Dis. (2001) [Pubmed]
  19. Antineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus: prevalence, antigen specificity, and clinical associations. Manolova, I., Dancheva, M., Halacheva, K. Rheumatol. Int. (2001) [Pubmed]
  20. Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial mediterranean fever. Chae, J.J., Centola, M., Aksentijevich, I., Dutra, A., Tran, M., Wood, G., Nagaraju, K., Kingma, D.W., Liu, P.P., Kastner, D.L. Mamm. Genome (2000) [Pubmed]
  21. Serum ferritin as a serologic marker of activity in systemic lupus erythematosus. Lim, M.K., Lee, C.K., Ju, Y.S., Cho, Y.S., Lee, M.S., Yoo, B., Moon, H.B. Rheumatol. Int. (2001) [Pubmed]
  22. Plasma concentration of IL-6 in systemic lupus erythematosus; an indicator of disease activity? Spronk, P.E., ter Borg, E.J., Limburg, P.C., Kallenberg, C.G. Clin. Exp. Immunol. (1992) [Pubmed]
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