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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Tuberculoma


High impact information on Tuberculoma

  • The patient was continued on isoniazid and rifampin, with radiographic resolution of the tuberculoma 4 months later [6].
  • Following 9 months of treatment with isoniazid, ethambutol, rifampin, and pyrazinamide, most lesions resolved; however, one cortical tuberculoma enlarged significantly [6].
  • Both the limb dystonia and the tuberculoma resolved with maintained antituberculous treatment [7].
  • RESULTS: Nine of 10 tuberculomas showed FDG uptake at PET, and the mean peak standardized uptake value was 4.2 +/- 2.2 (SD) [8].
  • Though not histologically verified, it seems justified to conclude that in India a ring or disc enhancing lesion is the commonest accompaniment of focal epilepsy, and that at least one third (and probably more) of these lesions are tuberculomas [9].

Chemical compound and disease context of Tuberculoma

  • Fluorescein angiographic findings were compatible with the clinical diagnosis of a choroidal tuberculoma [10].
  • MT ratios from all the 33 lesions were consistent with tuberculomas while PMRS showed choline along with lipids in 7 predominantly cellular lesions simulating a neoplasm [11].
  • After gadolinium-DTPA enhancement, 2 malignant tumors and 7 tuberculomas showed a marginal rim enhancement pattern, whereas 15 malignant tumors and 2 tuberculomas revealed a diffuse enhancement [12].
  • Among the infective masses, pyogenic abscesses (n = 6) showed resonances only from cytosolic amino acids, lactate, alanine, and acetate; and tuberculomas (n = 11) showed only lipid resonances [13].
  • The choline/creatine ratio was greater than 1 in all tuberculomas but in none of the cysticerci [14].

Biological context of Tuberculoma


Anatomical context of Tuberculoma


Gene context of Tuberculoma

  • Only tuberculomas were associated with a midline shift on CT (four of six cases) [18].
  • Because of the possibility of late development of tuberculomas after initial successful treatment, all TBM patients need to be followed-up carefully for a long period [2].
  • Case report: hypothalamic tuberculoma associated with secondary panhypopituitarism [3].
  • There was no statistically significant difference between the outcome of the patients with and without CSF paradoxical response; however, new tuberculomas developed more frequently in the first group (p < 0.05) [19].
  • Reported here is an obstruction of the right ventricular outflow tract caused by a tuberculoma in a 15-year-old boy who presented with a ventricular septal defect [20].

Analytical, diagnostic and therapeutic context of Tuberculoma


  1. Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain. Venkatesh, S.K., Gupta, R.K., Pal, L., Husain, N., Husain, M. Journal of magnetic resonance imaging : JMRI. (2001) [Pubmed]
  2. Clinical and radiological features of symptomatic central nervous system tuberculomas. Unal, A., Sutlas, P.N. Eur. J. Neurol. (2005) [Pubmed]
  3. Case report: hypothalamic tuberculoma associated with secondary panhypopituitarism. Flannery, M.T., Pattani, S., Wallach, P.M., Warner, E. Am. J. Med. Sci. (1993) [Pubmed]
  4. Mefloquine-induced grand mal seizure in tubercular meningitis. Bregani, E.R., Tien, T.V., Figini, G. Panminerva medica. (1998) [Pubmed]
  5. Convulsions in tuberculous meningitis. Patwari, A.K., Aneja, S., Ravi, R.N., Singhal, P.K., Arora, S.K. J. Trop. Pediatr. (1996) [Pubmed]
  6. Clinical and radiographic findings in disseminated tuberculosis of the brain. Eide, F.F., Gean, A.D., So, Y.T. Neurology (1993) [Pubmed]
  7. Focal limb dystonia in a patient with a cerebellar mass. Alarcón, F., Tolosa, E., Muñoz, E. Arch. Neurol. (2001) [Pubmed]
  8. Pulmonary tuberculoma evaluated by means of FDG PET: findings in 10 cases. Goo, J.M., Im, J.G., Do, K.H., Yeo, J.S., Seo, J.B., Kim, H.Y., Chung, J.K. Radiology. (2000) [Pubmed]
  9. Focal epilepsy in India with special reference to lesions showing ring or disc-like enhancement on contrast computed tomography. Wadia, R.S., Makhale, C.N., Kelkar, A.V., Grant, K.B. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  10. A case of pulmonary tuberculosis presenting with a choroidal tuberculoma. Jabbour, N.M., Faris, B., Trempe, C.L. Ophthalmology (1985) [Pubmed]
  11. Comparative evaluation of magnetization transfer MR imaging and in-vivo proton MR spectroscopy in brain tuberculomas. Gupta, R.K., Husain, M., Vatsal, D.K., Kumar, R., Chawla, S., Husain, N. Magnetic resonance imaging. (2002) [Pubmed]
  12. MR imaging of solitary pulmonary lesion: emphasis on tuberculomas and comparison with tumors. Chung, M.H., Lee, H.G., Kwon, S.S., Park, S.H. Journal of magnetic resonance imaging : JMRI. (2000) [Pubmed]
  13. Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. Poptani, H., Gupta, R.K., Roy, R., Pandey, R., Jain, V.K., Chhabra, D.K. AJNR. American journal of neuroradiology. (1995) [Pubmed]
  14. Differential diagnosis between cerebral tuberculosis and neurocysticercosis by magnetic resonance spectroscopy. Pretell, E.J., Martinot, C., Garcia, H.H., Alvarado, M., Bustos, J.A., Martinot, C. Journal of computer assisted tomography. (2005) [Pubmed]
  15. Development of tuberculoma during therapy presenting as hemianopsia. Tsai, M.H., Huang, Y.C., Lin, T.Y. Pediatric neurology. (2004) [Pubmed]
  16. Intracardiac tuberculoma. Chang, B.C., Ha, J.W., Kim, J.T., Chung, N., Cho, S.H. Ann. Thorac. Surg. (1999) [Pubmed]
  17. Disseminated tuberculomas in spinal cord and brain demonstrated by MRI with gadolinium-DTPA. Shen, W.C., Cheng, T.Y., Lee, S.K., Ho, Y.J., Lee, K.R. Neuroradiology. (1993) [Pubmed]
  18. Differentiating solitary small cysticercus granulomas and tuberculomas in patients with epilepsy. Clinical and computerized tomographic criteria. Rajshekhar, V., Haran, R.P., Prakash, G.S., Chandy, M.J. J. Neurosurg. (1993) [Pubmed]
  19. Tuberculous meningitis in adults: review of 61 cases. Sütlaş, P.N., Unal, A., Forta, H., Senol, S., Kirbaş, D. Infection (2003) [Pubmed]
  20. Obstruction of the right ventricular outflow tract caused by a tuberculoma in a patient with ventricular septal defect and aneurysm of the membranous septum. Santos, C.L., Moraes, F., Moraes, C.R. Cardiology in the young. (1999) [Pubmed]
  21. In vivo tuberculoma creation and its radioimmunoimaging. Hazra, D.K., Lahiri, V.L., Saran, S., Kant, P., Kumari, M., Arvind, B., Khandelwal, S., Elhence, B.R., Elhence, I.P., Singh, K. Nuclear medicine communications. (1987) [Pubmed]
  22. Surgery for expansion of spinal tuberculoma during antituberculous chemotherapy: a case report. Nomura, S., Akimura, T., Kitahara, T., Nogami, K., Suzuki, M. Pediatric neurosurgery. (2001) [Pubmed]
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