Disease relevance of Ovum Transport

• The increased PGF in peritoneal fluid may alter follicular rupture, ovum transport, corpus luteum function, or implantation, thus representing a mechanism by which endometriosis may cause infertility [1].
• These data suggested that LPA stimulates mouse ovum transport by contracting oviductual smooth muscle via a voltage-sensitive calcium channel mediated by a pertussis toxin-sensitive G-protein-linked receptor [2].
• In the assessment of drug safety with respect to mammalian reproductive function chlorpromazine and two serotonin antagonists, mianserin (Org GB94 ) and Org GC94 were studied for their effects on ovulation and ovum transport [3].

High impact information on Ovum Transport

• Effectiveness of different estrogen pulses in plasma for accelerating ovum transport and their relation to estradiol levels in the rat oviduct [4].
• All three inhibitors partially blocked the E2-induced ovum transport acceleration, whereas administration of inhibitors alone did not affect oviductal egg recovery [5].
• To study the relative contribution of cilia to ovum transport in the rat, we blocked smooth muscle activity with isoproterenol, a beta-adrenergic agonist, and measured transport rates of surrogate ova in situ [6].
• We investigated the temporal relationships between ovum transport and changes in the concentration of nuclear steroid receptors in the oviduct of cyclic and pregnant rats [7].
• These results demonstrate a different physiological importance of endogenous progesterone in slowing down oviductal ovum transport in cycling and pregnant rats.(ABSTRACT TRUNCATED AT 250 WORDS)[8]

Biological context of Ovum Transport

• Infusions of VIP for 60 min at the P peak, and for 240 min at the time of ovulation, had no significant effect upon ovum pickup or the rate of ovum transport [9].
• Administration of progesterone (im, 2.5 mg) produced complete relaxation of both isthmus and ampulla, did not produce increased isthmic contractility on coitus, accelerated the ovum transport rate and inhibited pregnancy, again emphasising the ova retentive role of oviductal motility [10].
• We suggest that a rise in pelvic venous pressure could lead to a decrease in isthmic luminal diameter and thus act as a sphincter contributing to the known delay in ovum transport at the ampullary isthmic junction [11].

Anatomical context of Ovum Transport

• The results described are consistent with the hypothesis that differential sperm and ovum transport in the human fallopian tube isthmus is at least partially determined by the presence or absence of estrogen-dependent luminal mucus [12].
• Our data suggest that normal tubal patency and ovum transport function can be tested by introducing radioactive ovum surrogates of appropriate size into the oviducts and monitoring their time of arrival at the uterus [13].

Associations of Ovum Transport with chemical compounds

• Effects of indomethacin and ICI 46,474 administered during ovum transport on fertility in rabbits [14].
• Thus, RU486 failed to accelerate ovum transport during the first three days of treatment in pregnant rats, in spite of the fact that no progesterone receptors were available in the oviduct as early as 24 h of treatment [8].
• Effect of inhibitors of prostaglandin synthesis and metabolism on ovum transport in the rabbit [15].
• Effect of 15(S)-15-methyl prostaglandin F2alpha on human oviductal motility and ovum transport [16].
• Poly I:C accelerates ovum transport in the rabbit by a prostaglandin-mediated mechanism [17].

Gene context of Ovum Transport

• To test the hypothesis that a primary (although undefined) disturbance of ovum transport may lead to faulty uterine implantation and so to abortion, the author examined the case records of 273 patients who underwent nonmicrosurgical bilateral tubal surgery for infertility at King George V Memorial Hospital, Sydney, between 1966 and 1975 [18].

Analytical, diagnostic and therapeutic context of Ovum Transport

• Effects of passive immunization against oestradiol on mouse ovum transport [19].

References