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Chemical Compound Review

Soltamox     2-[4-[(Z)-1,2-diphenylbut-1- enyl]phenoxy]...

Synonyms: Ginarsan, Ledertam, Nourytan, Tamoplex, Zynoplex, ...
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Disease relevance of Nolvadex


High impact information on Nolvadex


Chemical compound and disease context of Nolvadex


Biological context of Nolvadex


Anatomical context of Nolvadex

  • The administration of ICI 46474 at 17.00 h of dioestrus did not reduce preoptic responsiveness on the morning of the next day, suggesting that this compound does not act as an 'antioestrogen' at the level of the preoptic area [17].
  • In vitro incubation of monocytes from patients with breast cancer in the presence of tamoxifen (Nolvadex) resulted in significant inhibition of giant cell formation (P less than 0.000003; paired Student's t-test) [18].

Associations of Nolvadex with other chemical compounds


Gene context of Nolvadex


Analytical, diagnostic and therapeutic context of Nolvadex


  1. Tamoxifen. Use in treatment of metastatic breast cancer refractory to combination chemotherapy. Legha, S.S., Buzdar, A.U., Hortobagyi, G.N., Wiseman, C., Benjamin, R.S., Blumenschein, G.R. JAMA (1979) [Pubmed]
  2. Adjuvant endocrine therapy for postmenopausal women with early breast cancer. Ingle, J.N. Clin. Cancer Res. (2006) [Pubmed]
  3. 2-bromo-alpha-ergocryptine (CB-154) and tamoxifen (ICI 46,474) induced suppression of the genesis of mammary carcinomas in female rats treated with 7,12-dimethylbenzanthracene (DMBA): a comparison. Welsch, C.W., Goodrich-Smith, M., Brown, C.K., Mackie, D., Johnson, D. Oncology (1982) [Pubmed]
  4. A recurrent pelvic desmoid tumor successfully treated with tamoxifen. Sportiello, D.J., Hoogerland, D.L. Cancer (1991) [Pubmed]
  5. Adenocarcinoma of the pancreas--a hormone sensitive tumor? A preliminary report on Nolvadex treatment. Theve, N.O., Pousette, A., Carlström, K. Clinical oncology. (1983) [Pubmed]
  6. Quantification of cytochrome P-450-dependent cyclohexane hydroxylase activity in normal and neoplastic reproductive tissues. Senler, T.I., Dean, W.L., Murray, L.F., Wittliff, J.L. Biochem. J. (1985) [Pubmed]
  7. Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basicity. Robertson, D.W., Katzenellenbogen, J.A., Hayes, J.R., Katzenellenbogen, B.S. J. Med. Chem. (1982) [Pubmed]
  8. Effects of hypophysectomy, ovariectomy, and cycloheximide on specific binding sites for lactogenic hormones in rat liver. Kelly, P.A., Posner, B.I., Friesen, H.G. Endocrinology (1975) [Pubmed]
  9. Combined endocrine effects of LHRH agonist (Zoladex) and tamoxifen (Nolvadex) therapy in premenopausal women with breast cancer. Robertson, J.F., Walker, K.J., Nicholson, R.I., Blamey, R.W. The British journal of surgery. (1989) [Pubmed]
  10. Effects of indomethacin and ICI 46,474 administered during ovum transport on fertility in rabbits. Hodgson, B.J. Biol. Reprod. (1976) [Pubmed]
  11. Evolving role of toremifene in the adjuvant setting. Holli, K. Oncology (Williston Park, N.Y.) (1997) [Pubmed]
  12. Prolonged oestrogenic and mitogenic activity of tamoxifen in the ovariectomized mouse. Martin, L., Middleton, E. J. Endocrinol. (1978) [Pubmed]
  13. Cytochrome P-450 activity in human leiomyoma and normal myometrium. Senler, T.I., Hofmann, G.E., Sanfilippo, J.S., Barrows, G.H., Dean, W.L., Wittliff, J.L. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  14. Comparison of bioavailability in man of tamoxifen after oral and rectal administration. Tukker, J.J., Blankenstein, M.A., Nortier, J.W. J. Pharm. Pharmacol. (1986) [Pubmed]
  15. The bioavailability of Tamoplex (tamoxifen). Part 1. A pilot study. McVie, J.G., Simonetti, G.P., Stevenson, D., Briggs, R.J., Guelen, P.J., de Vos, D. Methods and findings in experimental and clinical pharmacology. (1986) [Pubmed]
  16. The bioavailability of Tamoplex (tamoxifen). Part 2. A single dose cross-over study in healthy male volunteers. Guelen, P.J., Stevenson, D., Briggs, R.J., de Vos, D. Methods and findings in experimental and clinical pharmacology. (1987) [Pubmed]
  17. Immunoreactive luteinizing hormone releasing factor in pituitary stalk blood from female rats: sex steroid modulation of response to electrical stimulation of preoptic area or median eminence. Sherwood, N.M., Chiappa, S.A., Fink, G. J. Endocrinol. (1976) [Pubmed]
  18. The effect of tamoxifen and medroxyprogesterone on giant cell formation by monocytes from patients with breast cancer. Al-Sumidaie, A.M. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  19. Selective estrogen-receptor modulators in 2001. O'Regan, R.M., Gradishar, W.J. Oncology (Williston Park, N.Y.) (2001) [Pubmed]
  20. Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse. Jordan, V.C. J. Reprod. Fertil. (1975) [Pubmed]
  21. The bioavailability of Tamoplex (tamoxifen). Part 3. A steady-state study in breast cancer patients. Slee, P.H., De Vos, D., Chapman, D., Stevenson, D. Pharmaceutisch weekblad. Scientific edition. (1988) [Pubmed]
  22. Therapeutic use of tamoxifen in advanced breast cancer: correlation with biochemical parameters. Morgan, L.R., Schein, P.S., Woolley, P.V., Hoth, D., Macdonald, J., Lippman, M., Posey, L.E., Beazley, R.W. Cancer treatment reports. (1976) [Pubmed]
  23. The relationship between histological grade, oestrogen receptor status, events and survival at 8 years in the NATO ('Nolvadex') trial. Singh, L., Wilson, A.J., Baum, M., Whimster, W.F., Birch, I.H., Jackson, I.M., Lowrey, C., Palmer, M.K. Br. J. Cancer (1988) [Pubmed]
  24. The early results from a randomised study of radiotherapy versus Nolvadex (tamoxifen) as initial treatment for stage III breast cancer. Williams, M.R., Gilson, D., Marsh, L., Morgan, D.A., Nicholson, R.I., Elston, C.W., Griffiths, K., Blamey, R.W. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1988) [Pubmed]
  25. Tamoxifen (Nolvadex) versus adrenalectomy in metastatic breast cancer. Nemoto, T., Patel, J., Rosner, D., Dao, T.L. Cancer (1984) [Pubmed]
  26. Adjuvant treatment for breast cancer in the elderly. Marchei, P., Bianco, V., Pignatelli, E., Chiodini, S., Santini, D., Carico, E., Marchei, M., Vecchione, A. Anticancer Res. (1996) [Pubmed]
  27. Effect of medication on biomechanical properties of rabbit bones: heparin induced osteoporosis. Akkas, N., Yeni, Y.N., Turan, B., Delilbasi, E., Gunel, U. Clin. Rheumatol. (1997) [Pubmed]
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