Disease relevance of Oral Ulcer

• Stomatitis and mouth ulcers may occur frequently with zalcitabine therapy but tend to resolve with continuing treatment [1].
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) was diagnosed in a 22-year-old man after a 1-year history of periodic fever, myalgia, conjunctivitis, cervical lymphadenopathy, and oral ulcers [2].
• Behçet's disease is a multisystem disease characterised by the clinical triad of oral ulcers, genital ulcers and uveitis [3].
• There was an association between oral ulcers, genital ulcers, and erythema nodosum (Factor 1); and between superficial and deep vein thrombosis (Factor 2) [4].
• Dyspnea, fever and oral ulcer occurred successively during the initial 4 months of intermittent low-dose methotrexate pulse therapy [5].

Psychiatry related information on Oral Ulcer

• A large mouth ulcer, caused by a ferrous sulphate tablet in direct contact with oral mucosa in a patient with senile dementia [6].

High impact information on Oral Ulcer

• The patients taking azathioprine also had less frequent oral ulcers, genital ulcers, and arthritis [7].
• Thalidomide effective for AIDS-related oral ulcers [8].
• Proguanil, chloroquine, and mouth ulcers [9].
• Oral ulcers were reported in 7.8% and 4.7% of combination and zidovudine monotherapy arms, respectively [10].
• At fever development, acyclovir prophylaxis affected the incidence and localization pattern of oral ulcers [11].

Chemical compound and disease context of Oral Ulcer

• Pain relief of oral ulcer by dibucaine-film [12].
• There have been infrequent case reports of mouth ulcers in patients receiving nicorandil; causality has not been conclusively established, but product prescribing information indicates that an alternative treatment should be considered if persistent aphthous or severe mouth ulceration occurs [13].
• CONCLUSIONS: The authors review the literature with respect to the occurrence of oral ulcers associated with the use of sirolimus or mycophenolate mofetil and speculate on the causes of the high incidence of oral ulcers in their study group [14].
• CONCLUSIONS: It is important to continue FA supplementation over the long term in patients on methotrexate and FA in order to prevent them discontinuing treatment because of mouth ulcers or nausea and vomiting [15].
• Kimura's disease with oral ulcers: response to pentoxifylline [16].

Anatomical context of Oral Ulcer

• From this study we suggested that folic acid when applied topically may play a role in local stimulation of epithelial cell differentiation leading to enhanced healing of oral ulcers [17].
• Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers [18].

Gene context of Oral Ulcer

• At the age of 7 years, the patient developed a chilblain-like eruption with features of SLE, including leucopenia, oral ulcers, positive rheumatoid and antinuclear antibodies and positive anti-dsDNA, anti-Ro/SSA and anti-La/SSB antibodies [19].
• MGI 209 treatment should allow patients with chemotherapy-induced oral ulcers to drink and eat with significantly diminished pain or no pain [20].
• Whereas significant anti-65-kDa heat shock protein and anti-S. sanguis ST3 antibodies were also found in sera from patients with rheumatoid arthritis and recurrent oral ulcers, the anti-S. sanguis KTH-1, KTH-2, and KTH-3 antibodies were confined to BS [21].
• However, MvaI*2 homozygosity was significantly higher in SLE patients with photosensitivity (P = 0.03) or oral ulcers (P = 0.01) than in SLE patients without these features [22].
• All patients with C4AQ0 exhibited more than 5 ACR criteria including malar rash, oral ulcers, renal disorder, immunological disorder, anti-nuclear antibody, without hematological disorder [23].

Analytical, diagnostic and therapeutic context of Oral Ulcer

• Clinical evaluation of MGI 209, an anesthetic, film-forming agent for relief from painful oral ulcers associated with chemotherapy [20].
• Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil [14].
• A water-soluble three-layered oral mucosa-adhesive film made from hydroxypropyl cellulose containing dibucaine (0.25 mg of drug/cm(2)) was designed for alleviation of severe pain due to oral ulcers, caused by chemotherapy and/or radiotherapy [12].

References