Disease relevance of Encephalitis, Herpes Simplex

• Herpes simplex host/viral interaction database   with KEGG pathway analysis of the viral life cycle  
• Despite the presence of fulminant liver failure and evidence of herpes encephalitis in the other case, institution of therapy with acyclovir was associated with complete recovery in both patients [1].
• Animal models of cutaneous herpes simplex and herpetic encephalitis were used to demonstrate the antiviral potential of acyclovir [2].
• Of these, 9 were subjects with neuropsychiatric signs and symptoms and 12 were asymptomatic subjects, including 10 subjects from a valaciclovir multiple sclerosis trial and 2 subjects with recurrent herpes encephalitis [3].
• Repetitive synchronized cyclical oscillations of multisystem parameters subsequent to high-dose thiopental therapy for status epilepticus secondary to herpes encephalitis [4].
• Outside the MS and Mdemy groups, morphological evidence of virus associations with the BBB were found only in the acute and subacute viral encephalitides (three cases subacute sclerosing panencephalitis, one case of Herpes encephalitis) and in one case of disseminated Cytomegalovirus infection [5].

High impact information on Encephalitis, Herpes Simplex

• They also suggest that the selective uptake of drugs that exploit viral thymidine kinase for their antiviral effect can, by appropriate labeling, be used in conjunction with clinical neuroimaging techniques to define infected regions of human brain, thereby providing a new approach to the diagnosis of herpes encephalitis in man [6].
• Derivative of adenine arabinoside in experimental herpes encephalitis [7].
• In 2 children, herpes encephalitis had occurred during the first 2 years, but both later developed intractable epilepsy that led to neurosurgery [8].
• Adult-onset MELAS presenting as herpes encephalitis [9].
• Measurement of CMMG in CSF and/or serum is a promising tool in the diagnostic procedure for aciclovir- or valaciclovir-treated patients with neuropsychiatric symptoms and may help to differentiate between side effects and herpes encephalitis [3].
• A Database of HSV-1 host interactions at WikiGenes

Chemical compound and disease context of Encephalitis, Herpes Simplex

• Acyclovir in herpes encephalitis [10].
• Efficacy of adenine arabinoside (Ara-A) and cytarabine (Ara-C) in the treatment herpes encephalitis in animal model [11].
• Two patients died of septic complications within 3 months after starting treatment with thalidomide and dexamethasone and one patient of herpes encephalitis after 26 months of treatment with thalidomide alone [12].
• Renal blood flow was assessed qualitatively over a 30 min period in a rat model of herpes encephalitis by extra-renal scintigraphic imaging following the injection of 131I-labelled sodium iodohippurate [13].

Biological context of Encephalitis, Herpes Simplex

• Despite probable adequate acyclovir levels in the spinal fluid, a second episode or progression of herpetic encephalitis occurred, suggesting impairment of host defenses, particularly cellular immunity [14].

Anatomical context of Encephalitis, Herpes Simplex

• Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction [15].
• We report a 1 month-old infant with congenitally acquired HIV infection, and herpes encephalitis; she presented a sudden cardiorespiratory arrest followed by coma and was found to have a giant saccular aneurysm of the left basilar artery [16].

Gene context of Encephalitis, Herpes Simplex

• Herpes encephalitis, commoner in adults than children, is an insidious severe disease with mortality related to the depth of coma [17].
• We studied two patients with herpes encephalitis (HSE) by [99mTc]HMPAO and [123I]iomazenil single photon emission computed tomography [18].
• However, sera from two patients with a presumptive diagnosis of acute herpes encephalitis based on clinical and cerebrospinal fluid findings were positive, showing high titers in our test [19].
• In patients with herpes encephalitis, two distinct types of diffusion imaging findings (on b=1000s/mm(2) images, and ADC maps) were noted: lesions similar to cytotoxic edema, and lesions similar to vasogenic edema [20].

References