Disease relevance of Sodium iodohippurate

• The sensitivity and specificity of the hypertensive intravenous pyelogram and the iodohippuran renogram have been determined for the diagnosis of renovascular disease, and cost-effectiveness calculations have been made for the diagnosis and surgical treatment of patients with renovascular hypertension [1].
• The diagnosis of factitious hyperinsulinism was ultimately proved by the finding of radioactivity in the patient's urine after 131-I Hippuran was added to a vial of insulin found in the patient's room [2].
• Prognosis for recovery of function in acute renal failure. Value of the renal image obtained using iodohippurate sodium I 131 [3].
• Twenty-four survivors of acute, nonobstructive, nonnephritic renal failure had a renal scan using iodohippurate sodium I 131 performed early in the acute illness [3].
• [131I] Hippuran renography in the detection of orthostatic hypertension [4].

High impact information on Sodium iodohippurate

• The renal plasma flow (clearance of 131I-labeled hippuran), urinary albumin excretion rate (radioimmunoassay), fractional albumin clearance, and renal vascular resistance were unchanged in both groups [5].
• Glomerular filtration rate (TcDTPA clearance) and effective renal plasma flow (hippuran clearance) as well as 24-hour urinary excretion of electrolytes and albumin were estimated at about 1 and 2.5 years of follow-up [6].
• In this setting, a captopril renal scan with hippuran and diethylenetriamine pentaacetic acid (DTPA) provides physiological information regarding the renal blood flow and GFR of each kidney [7].
• The patient presented with fibromuscular dysplasia of the renal arteries, which was shown by hippuran renography to be functionally significant on the right side [8].
• Serial radionuclide studies using both Tc-99m DTPA (perfusion) and I-131 hippuran (tubular function) were correlated with histologic findings in 25 patients with renal transplants [9].

Chemical compound and disease context of Sodium iodohippurate

• Failure to visualize a kidney on radionuclide scanning using technetium-99m (99mTc) chelates and other renal radiopharmaceuticals such as iodine-131 hippuran has been described as potentially misleading in patients who have acute renal failure due to acute tubular necrosis and urinary tract obstruction [10].
• It is concluded that the stimulation of diuresis with furosemide and its quantification represent an important additional step in the evaluation of dynamic I-123 Hippuran studies to detect renal ischemia [11].

Biological context of Sodium iodohippurate

• The glomerular filtration rate (GFR) and renal plasma flow were estimated from the clearances of radiolabeled thalamate and hippuran [12].
• Simultaneously, an increase of 75 +/- 31% in renal vascular resistance (P less than 0.05) was observed and the extraction fraction of 125I hippuran increased from 0.67 +/- 0.05 to 0.74 +/- 0.05 (P less than 0.01) [13].
• Its plasma protein binding was in the same order as that of Hippuran and much lower than that of 99mTc-MAG3 [14].
• These scans, which are clearly superior in anatomical detail to earlier scans using 131I hippuran, can be obtained along with the 131I hippuran renogram when the patient comes to the nuclear medicine department [15].
• Although cardiac output and systemic vascular resistance did not change significantly between the three study periods, infrarenal aortic cross-clamping decreased 125I hippuran clearance by 29 +/- 15% (P less than 0.05) and renal blood flow by 38 +/- 14% (P less than 0.001) [13].

Anatomical context of Sodium iodohippurate

• Three similar kidneys with simultaneous recanalization of both renal arteries had normal Hippuran scintiphotos [16].
• A 131I hippuran renogram, split urinary function studies and renal vein renins were normal [17].
• The thyroid uptake of radioactive iodine after scintillation camera studies using -131I-labeled hippuran was studied and the radiation dose calculated in 30 euthyroid children with normal renal function [18].
• Renal, ureteral, and vesicle functions were evaluated in 209 patients with obstructive lesions of the ureter due to schistosomiasis haematobia (bilharziasis), using Hippuran I131 extended renography [19].
• A mathematical model of the cerebrospinal fluid (CSF) flow dynamics found in hydrocephalic infants with myelomeningocele lesions was constructed using criteria obtained from analogous clinical situations where 125I-labelled and 131I-labelled ortho-iodobenzoyl-amino-acetic acid (hippuran) had been employed to measure CSF flow dynamics [20].

Associations of Sodium iodohippurate with other chemical compounds

• We measured simultaneous glomerular filtration rate (GFR) and renal plasma flow (RPF) in 29 (4 female) subjects, mean age 52 years (range 27-70), using 51Cr EDTA and 125I Hippuran [21].
• Treatment failure was defined as continuing deterioration on T131 iodohippuran scan, rising serum creatinine level, or lack of improvement within 7 days [22].
• Quantitative evaluation of iodine-123 hippuran gamma camera renography in normal children [23].
• Iodine-131 Hippuran for the estimation of renal plasma flow: requirements for radiochemical purity [24].
• 99mTc dimercaptosuccinic acid is a new renal scanning agent that provides a good quality of renal image as a result of preferential cortical accumulation and also makes feasible a quantitative assessment of separate kidney function, correlating well with renal plasma flow obtained from a 131I hippuran renogram of each kidney [25].

Gene context of Sodium iodohippurate

• Both PAH and I-131 hippuran accumulated in all cysts suggesting intact tubular secretory mechanisms [26].
• 131I hippuran quantitative scintillation camera studies in the evaluation and management of vesicoureteral reflux [27].
• Detection was facilitated by the use of hypertensive intravenous pyelography and Hippuran renal Scanning. Aortography proved the presence of renal artery disease and renal vein renin assay established its significance in the etiology of the patients' hypertension [28].
• 2. ANP induced a rise in packed cell volume and a slight increase (but no decrease) in the renal extraction of hippuran [29].
• In conclusion, MDP cannot replace Hippuran as a renal radionuclide agent, mainly due to its lower extraction ratio and the high bone uptake [30].

Analytical, diagnostic and therapeutic context of Sodium iodohippurate

• Scans were judged according to whether the renal images were prominent, faint, or absent during the first 30 minutes after intravenous injection of 100 to 250 microcuries of iodohippurate sodium I 131 [3].
• I-125 Hippuran renography was performed before clamping, immediately after clamp release, and at 2, 4, 6, and 14 days later [31].
• Preliminary screening by serial gamma camera imaging in rabbits showed that most analogs had a higher liver uptake and/or slower renal clearance, than hippuran [32].
• I-131 Hippuran renography of functioning grafts was carried out 397 times, and the Tc-99m sequential scintigraphy 379 times [33].
• Functional impairment of the obstructed kidney was demonstrated more often with 131I Hippuran (o-iodohippurate sodium) (91%) than with 99mTc glucoheptonate (68%) or excretory urography (66%) [34].

References