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Gene Review

CCV  -  cataract, congenital, Volkmann type

Homo sapiens

Synonyms: CTRCT8
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Disease relevance of CCV

  • Pairwise comparisons of the S amino acid sequences within the antigenic cluster demonstrated that the two CCV strains (K378 and Insavc-1) are 93.3% identical, about as similar to each other as they are to the two feline coronaviruses [1].
  • We have cloned, sequenced and expressed the spike (S) gene of canine coronavirus (CCV; strain K378) [1].
  • Like other representatives of the same antigenic cluster (CCV-Insavc-1 strain, feline infectious peritonitis and enteric coronaviruses, porcine transmissible gastroenteritis and respiratory coronaviruses, and the human coronavirus HCV 229E), the CCV S polypeptide lacks a proteolytic cleavage site present in many other coronavirus S proteins [1].
  • Expression of the CCV S gene using the vaccinia virus T7 RNA polymerase system yielded a protein of the expected M(r) (approximately 200K) which could be immunoprecipitated with an anti-feline infectious peritonitis virus polyclonal serum and which was indistinguishable from the S protein synthesized in CCV-infected cells [1].
  • Four patients died of toxicity, and one developed dialysis-dependent renal failure, while the others tolerated CCV well [2].

High impact information on CCV


Chemical compound and disease context of CCV

  • We conclude that CCV chemotherapy with autografting is tolerated well by extensively pre-treated myeloma patients provided the pre-transplant creatinine is normal, but toxicity in patients with abnormal renal function is high [2].

Biological context of CCV

  • Total haemoglobin, Hb A2, PCV, CCV, and red cell count were significantly higher and MCV, MCH, MCHC, and ISC counts significantly lower in Sbeta0 thalassaemia [7].

Anatomical context of CCV

  • By contrast, these cell lines were generally resistant to VHSV, IHNV and IPNV, with varying susceptibility to RC and CCV [8].
  • CCV-PTC is a recently described rare tumor of the thyroid that has been associated with an aggressive clinical course [9].
  • Animal coronaviruses related to HCV-229E, including FIPV, CCV, and TGEV bind to cell membranes from cats, dogs, cows, pigs and humans (but not mice), while each virus infects cells from only a subset of these species [10].

Associations of CCV with chemical compounds

  • Second, the effect of a 2-h glycopyrrolate i.v. infusion (5 micrograms/kg/h) on the mean R-R interval (RRI) and the Hayano index of the high frequency variability of RRI (HF CCV) was modelled using an effect-compartment, inhibitory sigmoidal Emax model, with the individual PK parameters from the first part as constants [11].
  • The next protocols (CALGB 7781 and 7782) compared two adriamycin containing regimens: MACC (methotrexate, adriamycin, cyclophosphamide, CCNU) versus CCV/AV (cyclophosphamide, CCNU, vincristine, alternating with adriamycin and vincristine) [12].

Other interactions of CCV

  • BACKGROUND AND OBJECTIVES: Tall cell (TCV), columnar cell (CCV), insular (IC), diffuse sclerosing (DSPTC) and solid/trabecular are uncommon subtypes of thyroid cancer, which have generally been described in case reports or small series in the world literature [13].

Analytical, diagnostic and therapeutic context of CCV


  1. Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses. Wesseling, J.G., Vennema, H., Godeke, G.J., Horzinek, M.C., Rottier, P.J. J. Gen. Virol. (1994) [Pubmed]
  2. High-dose chemotherapy with carboplatin, cyclophosphamide and etoposide and autologous transplantation for multiple myeloma relapsing after a previous transplant. Mehta, J., Tricot, G., Jagannath, S., Desikan, K.R., Siegel, D., Singhal, S., Munshi, N., Vesole, D., Mattox, S., Bracy, D., Barlogie, B. Bone Marrow Transplant. (1997) [Pubmed]
  3. Phase I/II study of cyclophosphamide, carboplatin, and etoposide and autologous hematopoietic stem-cell transplantation with posttransplant interferon alfa-2b for patients with lymphoma and Hodgkin's disease. Schenkein, D.P., Dixon, P., Desforges, J.F., Berkman, E., Erban, J.K., Ascensao, J.L., Miller, K.B. J. Clin. Oncol. (1994) [Pubmed]
  4. On the contribution of quantal secretion from close-contact and loose-contact varicosities to the synaptic potentials in the vas deferens. Bennett, M.R., Gibson, W.G. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1995) [Pubmed]
  5. Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells. Patil, R., Chavez, J.B., Yee, D. Breast Cancer Res. Treat. (2000) [Pubmed]
  6. Effect of dehydrating agents on DNA organization in herpes viruses. Puvion-Dutilleul, F., Pichard, E., Laithier, M., Leduc, E.H. J. Histochem. Cytochem. (1987) [Pubmed]
  7. Comparison of sickle cell-beta0 thalassaemia with homozygous sickle cell disease. Serjeant, G.R., Sommereux, A.M., Stevenson, M., Mason, K., Serjeant, B.E. Br. J. Haematol. (1979) [Pubmed]
  8. Viral susceptibility of newly established cell lines from the Hawaiian monk seal Monachus schauinslandi. Lu, Y., Aguirre, A.A., Wang, Y., Zeng, L., Loh, P.C., Yanagihara, R. Dis. Aquat. Org. (2003) [Pubmed]
  9. Solitary parotid metastasis from columnar cell carcinoma of the thyroid: a diagnostic dilemma. Kini, H., Pai, R.R., Kalpana, S. Diagn. Cytopathol. (2003) [Pubmed]
  10. Multiple receptor-dependent steps determine the species specificity of HCV-229E infection. Levis, R., Cardellichio, C.B., Scanga, C.A., Compton, S.R., Holmes, K.V. Adv. Exp. Med. Biol. (1995) [Pubmed]
  11. Pharmacokinetic-pharmacodynamic model for the anticholinergic effect of glycopyrrolate. Penttilä, J., Helminen, A., Luomala, K., Scheinin, H. Eur. J. Clin. Pharmacol. (2001) [Pubmed]
  12. Small cell anaplastic carcinoma of the lung. The Cancer and Leukemia Group B Experience. Chahinian, A.P., Comis, R.L., Maurer, L.H., Pajak, T.F. Bulletin du cancer. (1982) [Pubmed]
  13. A review of thyroid cancer with intermediate differentiation. Sywak, M., Pasieka, J.L., Ogilvie, T. Journal of surgical oncology. (2004) [Pubmed]
  14. Primary prevention of heart disease and stroke: a simplified approach to estimating risk of events and making drug treatment decisions. McCormack, J.P., Levine, M., Rangno, R.E. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1997) [Pubmed]
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