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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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High impact information on Platypus

  • As a first step toward this goal, homologs of the eutherian amelogenin gene have been cloned and characterized in selected species of monotremes (platypus and echidna), reptiles (caiman), and amphibians (African clawed toad) [1].
  • Interestingly, internal cysteine bridges in the complementarity-determining region (CDR)3 loop, or between the CDR2 and CDR3 loops, are found in approximately 36% of the platypus V(H) sequences [2].
  • In a prototherian mammal, the platypus (Ornithorhynchus anatinus), none of the characteristic OR37 genes were found [3].
  • Whey Acidic Protein (WAP) has been identified in the milk of only a few species, including mouse, rat, rabbit, camel, pig, tammar wallaby, brushtail possum, echidna and platypus [4].
  • Comparisons of Gdf6 sequences from several placental mammals and platypus revealed many strongly conserved regions flanking Gdf6 and the adjacent Uqcrb gene [5].

Biological context of Platypus


Anatomical context of Platypus


Associations of Platypus with chemical compounds

  • Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus [12].
  • We have cloned and analyzed a large nuclear gene, the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R), from representatives of all three mammalian groups, including platypus, echidna, opossum, wallaby, hedgehog, mouse, rat, rabbit, cow, pig, bat, tree shrew, colugo, ringtail lemur, and human [13].
  • The distribution of 5-hydroxytryptamine in the gut of several species of birds and reptiles, and of a prototherian mammal, the platypus, was studied using a monoclonal antibody [14].
  • Equilibrium dialysis and polyacrylamide gel electrophoresis (PAGE) revealed no evidence for a transcortin-like glucocorticoid- and progesterone-binding protein in platypus plasma [15].
  • The neurohypophysial hormones of the egg-laying mammals: identification of arginine vasopressin in the platypus (Ornithorhynchus anatinus) [16].

Gene context of Platypus

  • SOX2 and SOX14 homologues were cloned and characterized in the platypus, a monotreme mammal distantly related to man [17].
  • Several clones containing DMP1 cDNA were isolated from a caiman tooth library by screening with a platypus DMP1 probe [18].
  • Except for parakeratotic tissues of platypus web, distribution of acidic and basic proteins in monotreme and marsupial epidermis as revealed by anti-keratin antibodies AE1, AE2, and AE3 resembles that of eutherian epidermis [11].
  • Phylogenetic structure of Zacco platypus (Teleostei, Cyprinidae) populations on the upper and middle Chang Jiang (=Yangtze) drainage inferred from cytochrome b sequences [19].
  • The purified protein modified the action of partially-purified galactosyltransferase from platypus milk to promote the synthesis of lactose, but had very little modifier effect on bovine galactosyltransferase [20].


  1. Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians. Toyosawa, S., O'hUigin, C., Figueroa, F., Tichy, H., Klein, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Heavy chain V region diversity in the duck-billed platypus (Ornithorhynchus anatinus): long and highly variable complementarity-determining region 3 compensates for limited germline diversity. Johansson, J., Aveskogh, M., Munday, B., Hellman, L. J. Immunol. (2002) [Pubmed]
  3. Evolution of the "OR37" Subfamily of Olfactory Receptors: A Cross-Species Comparison. Hoppe, R., Lambert, T.D., Samollow, P.B., Breer, H., Strotmann, J. J. Mol. Evol. (2006) [Pubmed]
  4. Ruminants genome no longer contains Whey Acidic Protein gene but only a pseudogene. Hajjoubi, S., Rival-Gervier, S., Hayes, H., Floriot, S., Eggen, A., Piumi, F., Chardon, P., Houdebine, L.M., Thépot, D. Gene (2006) [Pubmed]
  5. Comparative sequence analysis of the Gdf6 locus reveals a duplicon-mediated chromosomal rearrangement in rodents and rapidly diverging coding and regulatory sequences. Mortlock, D.P., Portnoy, M.E., Chandler, R.L., Green, E.D. Genomics (2004) [Pubmed]
  6. D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties. Torres, A.M., Tsampazi, C., Geraghty, D.P., Bansal, P.S., Alewood, P.F., Kuchel, P.W. Biochem. J. (2005) [Pubmed]
  7. Gene mapping in marsupials and monotremes, V. Synteny between hypoxanthine phosphoribosyltransferase and phosphoglycerate kinase in the platypus. Watson, J.M., Graves, J.A. Aust. J. Biol. Sci. (1988) [Pubmed]
  8. Distribution of substance P in the enteric plexuses of the small intestine of the platypus, Ornithorhynchus anatinus. Osborne, P.B., Campbell, G., Evans, B.K. Cell Tissue Res. (1989) [Pubmed]
  9. Cyto- and chemoarchitecture of the sensory trigeminal nuclei of the echidna, platypus and rat. Ashwell, K.W., Hardman, C.D., Paxinos, G. J. Chem. Neuroanat. (2006) [Pubmed]
  10. Studies on monotreme proteins. VII. Amino acid sequence of myoglobin from the platypus, Ornithoryhynchus anatinus. Fisher, W.K., Thompson, E.O. Aust. J. Biol. Sci. (1976) [Pubmed]
  11. Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammals. Alibardi, L., Maderson, P.F. J. Morphol. (2003) [Pubmed]
  12. Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus. Poorafshar, M., Aveskogh, M., Munday, B., Hellman, L. Immunogenetics (2000) [Pubmed]
  13. Marsupials and Eutherians reunited: genetic evidence for the Theria hypothesis of mammalian evolution. Killian, J.K., Buckley, T.R., Stewart, N., Munday, B.L., Jirtle, R.L. Mamm. Genome (2001) [Pubmed]
  14. The distribution of 5-hydroxytryptamine in the gastrointestinal tract of reptiles, birds and a prototherian mammal. An immunohistochemical study. Adamson, S., Campbell, G. Cell Tissue Res. (1988) [Pubmed]
  15. Glucocorticoids in the blood plasma of the platypus Ornithorynchus anatinus. McDonald, I.R., Than, K.A., Evans, B. J. Endocrinol. (1988) [Pubmed]
  16. The neurohypophysial hormones of the egg-laying mammals: identification of arginine vasopressin in the platypus (Ornithorhynchus anatinus). Chauvet, J., Hurpet, D., Michel, G., Chauvet, M.T., Carrick, F.N., Acher, R. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  17. Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution. Kirby, P.J., Waters, P.D., Delbridge, M., Svartman, M., Stewart, A.N., Nagai, K., Graves, J.A. Cytogenet. Genome Res. (2002) [Pubmed]
  18. Characterization of dentin matrix protein 1 gene in crocodilia. Toyosawa, S., O'hUigin, C., Tichy, H., Klein, J. Gene (1999) [Pubmed]
  19. Phylogenetic structure of Zacco platypus (Teleostei, Cyprinidae) populations on the upper and middle Chang Jiang (=Yangtze) drainage inferred from cytochrome b sequences. Perdices, A., Cunha, C., Coelho, M.M. Mol. Phylogenet. Evol. (2004) [Pubmed]
  20. Isolation, partial characterisation, and amino acid sequence of alpha-lactalbumin from platypus (Ornithorhynchus anatinus) milk. Shaw, D.C., Messer, M., Scrivener, A.M., Nicholas, K.R., Griffiths, M. Biochim. Biophys. Acta (1993) [Pubmed]
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