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Gene Review

DMP1  -  dentin matrix acidic phosphoprotein 1

Homo sapiens

Synonyms: ARHP, ARHR, DMP-1, Dentin matrix acidic phosphoprotein 1, Dentin matrix protein 1
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Disease relevance of DMP1

  • Because all of these proteins were also shown by immunohistochemistry to be expressed in serial sections of a colon adenocarcinoma, we have hypothesized that the MMP-9/DMP1/cell surface complexes observed to enhance cell invasion in vitro may be aiding metastatic events in vivo [1].
  • In this study, we used a modified Boyden chamber assay to show that DMP1 enhanced the invasiveness of the MMP-9 expressing colon cancer cell line, SW480, through Matrigel in a dose-dependant manner [1].
  • The role of DMP1 in lung cancer is largely unknown [2].
  • RESULTS: Our results show that DMP1 is detectable in 90% of the adenocarcinoma and squamous carcinoma analyzed while 8 of 10 bronchioloalveolar specimens were negative [2].
  • It was detectable in 80% of the cases, suggesting a potential role for DMP1 in tumor progression and bone metastasis [2].

High impact information on DMP1


Chemical compound and disease context of DMP1


Biological context of DMP1

  • In this study, we have used histological and RFLP analyses of tissues from a DGI-II-affected patient, as compared with two normal controls, to determine if DMP1, 2, or 3 was linked to DGI-II [8].
  • We envision that the proteolytic processing of DMP1 and DSPP may be an activation process that plays a significant, crucial role in osteogenesis and dentinogenesis, and that a failure in this processing would cause defective mineralization in bone and dentin, as observed in X-linked hypophosphatemic rickets [9].
  • Enforced coexpression of either of three D-type cyclins (D1, D2, or D3) with DMP1 in mammalian cells canceled its ability to activate gene expression [10].
  • In the extracellular matrix of these tissues DMP1 is present as fragments representing the NH2-terminal (37 kDa) and COOH-terminal (57 kDa) portions of the cDNA-deduced amino acid sequence [11].
  • We purified DMP1-PG with a monoclonal anti-DMP1 antibody affinity column [11].

Anatomical context of DMP1


Associations of DMP1 with chemical compounds

  • Our findings show that in addition to its existence as a phosphoprotein, the NH2-terminal fragment from DMP1 occurs as a proteoglycan [11].
  • Another member of this family, dentin matrix protein 1, is shown in this paper to be very similar to osteopontin in that it can bind strongly to Factor H (K(a) approximately 1 nm) and block the lytic activity through either the vitronectin receptor (alpha(V)beta(3) integrin) or CD44 [16].
  • Both full-length recombinant DMP1 and post-translationally modified native DMP1 were able to nucleate hydroxyapatite (HAP) in the presence of type I collagen [17].
  • Collagen matrix impregnated with recombinant DMP1 was implanted directly in Group 1, while calcium hydroxide, a commonly used pulp-capping agent was implanted in group 2, collagen matrix that was not impregnated with rDMP1 was implanted directly in group 3, which served as control [18].
  • The translated proto- and metatherian protein sequences are highly divergent from the eutherian sequences but retain the general characteristics of the DMP1 (high acidity, serine-richness, multiple glycosylation sites, and the presence of the RGD cell attachment tripeptide) [19].
  • Expression of alphaVbeta3 integrin enhanced HSG attachment to DMP1 and OPN and promoted haptotactic migration onto all three proteins [20].

Physical interactions of DMP1


Regulatory relationships of DMP1


Other interactions of DMP1


Analytical, diagnostic and therapeutic context of DMP1


  1. Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44. Karadag, A., Fedarko, N.S., Fisher, L.W. Cancer Res. (2005) [Pubmed]
  2. Dentin matrix protein 1 is expressed in human lung cancer. Chaplet, M., De Leval, L., Waltregny, D., Detry, C., Fornaciari, G., Bevilacqua, G., Fisher, L.W., Castronovo, V., Bellahcène, A. J. Bone Miner. Res. (2003) [Pubmed]
  3. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Feng, J.Q., Ward, L.M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S.I., Zhang, S., Rios, H., Drezner, M.K., Quarles, L.D., Bonewald, L.F., White, K.E. Nat. Genet. (2006) [Pubmed]
  4. Bone talk. Schiavi, S.C. Nat. Genet. (2006) [Pubmed]
  5. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Lorenz-Depiereux, B., Bastepe, M., Benet-Pag??s, A., Amyere, M., Wagenstaller, J., M??ller-Barth, U., Badenhoop, K., Kaiser, S.M., Rittmaster, R.S., Shlossberg, A.H., Olivares, J.L., Loris, C., Ramos, F.J., Glorieux, F., Vikkula, M., J??ppner, H., Strom, T.M. Nat. Genet. (2006) [Pubmed]
  6. Dentin bonding: effect of tubule orientation on hybrid-layer formation. Schüpbach, P., Krejci, I., Lutz, F. Eur. J. Oral Sci. (1997) [Pubmed]
  7. Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells. Portenier, I., Haapasalo, H., Orstavik, D., Yamauchi, M., Haapasalo, M. Journal of endodontics. (2002) [Pubmed]
  8. The non-collagenous dentin matrix proteins are involved in dentinogenesis imperfecta type II (DGI-II). Thotakura, S.R., Mah, T., Srinivasan, R., Takagi, Y., Veis, A., George, A. J. Dent. Res. (2000) [Pubmed]
  9. Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Qin, C., Baba, O., Butler, W.T. Crit. Rev. Oral Biol. Med. (2004) [Pubmed]
  10. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Inoue, K., Sherr, C.J. Mol. Cell. Biol. (1998) [Pubmed]
  11. A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment. Qin, C., Huang, B., Wygant, J.N., McIntyre, B.W., McDonald, C.H., Cook, R.G., Butler, W.T. J. Biol. Chem. (2006) [Pubmed]
  12. Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. Narayanan, K., Gajjeraman, S., Ramachandran, A., Hao, J., George, A. J. Biol. Chem. (2006) [Pubmed]
  13. Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth. Papagerakis, P., Berdal, A., Mesbah, M., Peuchmaur, M., Malaval, L., Nydegger, J., Simmer, J., Macdougall, M. Bone (2002) [Pubmed]
  14. Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression. Chen, S., Inozentseva-Clayton, N., Dong, J., Gu, T.T., MacDougall, M. J. Cell. Biochem. (2004) [Pubmed]
  15. Gene expression profiling of pulpal tissue reveals the molecular complexity of dental caries. McLachlan, J.L., Smith, A.J., Bujalska, I.J., Cooper, P.R. Biochim. Biophys. Acta (2005) [Pubmed]
  16. Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. Jain, A., Karadag, A., Fohr, B., Fisher, L.W., Fedarko, N.S. J. Biol. Chem. (2002) [Pubmed]
  17. Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. Gajjeraman, S., Narayanan, K., Hao, J., Qin, C., George, A. J. Biol. Chem. (2007) [Pubmed]
  18. Dentin matrix protein 1 induces cytodifferentiation of dental pulp stem cells into odontoblasts. Almushayt, A., Narayanan, K., Zaki, A.E., George, A. Gene Ther. (2006) [Pubmed]
  19. The dentin matrix protein 1 gene of prototherian and metatherian mammals. Toyosawa, S., O'hUigin, C., Klein, J. J. Mol. Evol. (1999) [Pubmed]
  20. Dentin matrix protein-1 isoforms promote differential cell attachment and migration. von Marschall, Z., Fisher, L.W. J. Biol. Chem. (2008) [Pubmed]
  21. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. Nakashima, M. J. Dent. Res. (1994) [Pubmed]
  22. Human odontoblast culture method: the expression of collagen and matrix metalloproteinases (MMPs). Tjäderhane, L., Palosaari, H., Wahlgren, J., Larmas, M., Sorsa, T., Salo, T. Adv. Dent. Res. (2001) [Pubmed]
  23. Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts. Durand, S.H., Flacher, V., Roméas, A., Carrouel, F., Colomb, E., Vincent, C., Magloire, H., Couble, M.L., Bleicher, F., Staquet, M.J., Lebecque, S., Farges, J.C. J. Immunol. (2006) [Pubmed]
  24. Refinement of the dentinogenesis imperfecta type II locus to an interval of less than 2 centiMorgans at chromosome 4q21 and the creation of a yeast artificial chromosome contig of the critical region. Aplin, H.M., Hirst, K.L., Dixon, M.J. J. Dent. Res. (1999) [Pubmed]
  25. Utility of the dentin matrix protein 1 (DMP1) gene for resolving mammalian intraordinal phylogenetic relationships. Van Den Bussche, R.A., Reeder, S.A., Hansen, E.W., Hoofer, S.R. Mol. Phylogenet. Evol. (2003) [Pubmed]
  26. Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia. Toyosawa, S., Tomita, Y., Kishino, M., Hashimoto, J., Ueda, T., Tsujimura, T., Aozasa, K., Ijuhin, N., Komori, T. Mod. Pathol. (2004) [Pubmed]
  27. Biological markers for evaluation of root resorption. Balducci, L., Ramachandran, A., Hao, J., Narayanan, K., Evans, C., George, A. Arch. Oral Biol. (2007) [Pubmed]
  28. Cluster analysis and gene expression profiles: A cDNA microarray system-based comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal stem cells (hMSCs) for tissue engineering cell therapy. Yamada, Y., Fujimoto, A., Ito, A., Yoshimi, R., Ueda, M. Biomaterials (2006) [Pubmed]
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