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MeSH Review


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Disease relevance of Adenoids


High impact information on Adenoids

  • PURPOSE: This study aimed to assess the antitumor activity of imatinib in adenoid cystic carcinoma (ACC) of the salivary gland expressing c-kit [6].
  • Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands [7].
  • Extracellular matrix production and degradation by adenoid cystic carcinoma cells: participation of plasminogen activator and its inhibitor in matrix degradation [8].
  • Adenoid cystic carcinoma (AdCC) is characterized by low mitogenic activity, high invasiveness, and vigorous production and accumulation of extracellular matrix (ECM) [8].
  • The cytotoxic reaction employed human peripheral blood or adenoid lymphocytes sensitized in MLC to allogeneic B lymphocyte cell lines and lysis was measured in a short-term 51Cr-release assay [9].

Chemical compound and disease context of Adenoids


Biological context of Adenoids


Anatomical context of Adenoids


Associations of Adenoids with chemical compounds


Gene context of Adenoids

  • In seven cases of adenoid cystic carcinoma (ACC), both duct-like cells and modified myoepithelial cells were apparently immunopositive for FGF-1, FGF-2, and FGFR-1 [27].
  • We also investigated the status of the PLAG1 gene in four cases (one PA, one CaPA, one adenoid cystic carcinoma, and one mucoepidermoid carcinoma) with 8q12 rearrangements [28].
  • We conclude that HMGB1, produced and stored intracellularly in the adenoid gland, contributes to the local antibacterial barrier defense system in the upper respiratory tract [29].
  • Our study shows that adenoid cystic carcinoma of the breast is a special, estrogen receptor, progesterone receptor, HER-2 negative and highly KIT-positive, basal-like breast carcinoma, associated with an excellent prognosis [30].
  • In this study, we investigated the mechanism of increased expression of SCC-Ag in a cell line SCCMM derived from an aggressive adenoid SCC with high titer of SCC-Ag in the patient serum [31].

Analytical, diagnostic and therapeutic context of Adenoids


  1. The anatomy of large inpatient waiting lists. Davidge, M., Harley, M., Vickerstaff, L., Yates, J. Lancet (1987) [Pubmed]
  2. Carboplatin (NSC-241-240): an active platinum analog for the treatment of squamous-cell carcinoma of the head and neck. Eisenberger, M., Hornedo, J., Silva, H., Donehower, R., Spaulding, M., Van Echo, D. J. Clin. Oncol. (1986) [Pubmed]
  3. An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. Yanagawa, T., Hayashi, Y., Yoshida, H., Yura, Y., Nagamine, S., Bando, T., Sato, M. Am. J. Pathol. (1986) [Pubmed]
  4. Leukotriene modifier therapy for mild sleep-disordered breathing in children. Goldbart, A.D., Goldman, J.L., Veling, M.C., Gozal, D. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  5. Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer. Ohta, Y., Endo, Y., Tanaka, M., Shimizu, J., Oda, M., Hayashi, Y., Watanabe, Y., Sasaki, T. Clin. Cancer Res. (1996) [Pubmed]
  6. Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital phase II consortium study. Hotte, S.J., Winquist, E.W., Lamont, E., MacKenzie, M., Vokes, E., Chen, E.X., Brown, S., Pond, G.R., Murgo, A., Siu, L.L. J. Clin. Oncol. (2005) [Pubmed]
  7. Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands. Faivre, S., Raymond, E., Casiraghi, O., Temam, S., Berthaud, P. J. Clin. Oncol. (2005) [Pubmed]
  8. Extracellular matrix production and degradation by adenoid cystic carcinoma cells: participation of plasminogen activator and its inhibitor in matrix degradation. Shirasuna, K., Saka, M., Hayashido, Y., Yoshioka, H., Sugiura, T., Matsuya, T. Cancer Res. (1993) [Pubmed]
  9. Mechanisms of lymphocyte-mediated cytotoxicity. I. The effects of anti-human lymphotoxin antisera on the cytolysis of allogeneic B cell lines by MLC-sensitized human lymphocytes in vitro. Ware, C.F., Granger, G.A. J. Immunol. (1981) [Pubmed]
  10. Phase II study on mitoxantrone in adenoid cystic carcinomas of the head and neck. EORTC Head and Neck Cancer Cooperative Group. Verweij, J., de Mulder, P.H., de Graeff, A., Vermorken, J.B., Wildiers, J., Kerger, J., Schornagel, J., Cognetti, F., Kirkpatrick, A., Sahmoud, T., Lefebvre, J.L. Ann. Oncol. (1996) [Pubmed]
  11. Epirubicin in patients with advanced or recurrent adenoid cystic carcinoma of the head and neck: a phase II study of the EORTC Head and Neck Cancer Cooperative Group. Vermorken, J.B., Verweij, J., de Mulder, P.H., Cognetti, F., Clavel, M., Rodenhuis, S., Kirkpatrick, A., Snow, G.B. Ann. Oncol. (1993) [Pubmed]
  12. Concentrations of azithromycin in tonsilar and/or adenoid tissue from paediatric patients. Vaudaux, B.P., Cherpillod, J., Dayer, P. J. Antimicrob. Chemother. (1996) [Pubmed]
  13. Immunohistochemical characterisation of extracellular matrix components of salivary gland tumours. Nara, Y., Takeuchi, J., Yoshida, K., Fukatsu, T., Nagasaka, T., Kawaguchi, T., Meng, N., Kikuchi, H., Nakashima, N. Br. J. Cancer (1991) [Pubmed]
  14. p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Emanuel, P., Wang, B., Wu, M., Burstein, D.E. Mod. Pathol. (2005) [Pubmed]
  15. Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma. Maruya, S., Kurotaki, H., Wada, R., Saku, T., Shinkawa, H., Yagihashi, S. Mod. Pathol. (2004) [Pubmed]
  16. Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands. Yamamoto, Y., Virmani, A.K., Wistuba, I.I., McIntire, D., Vuitch, F., Albores-Saavedra, J., Gazdar, A.F. Hum. Pathol. (1996) [Pubmed]
  17. Tenascin expression in adenoid basal cell carcinoma of the skin. Saitoh, M., Yamada, T., Shrestha, P., Yamada, K., Tsujimura, T., Mori, M. Anticancer Res. (1996) [Pubmed]
  18. Perlecan (heparan sulfate proteoglycan) gene expression reflected in the characteristic histological architecture of salivary adenoid cystic carcinoma. Kimura, S., Cheng, J., Ida, H., Hao, N., Fujimori, Y., Saku, T. Virchows Arch. (2000) [Pubmed]
  19. Molecular typing of paired bacterial isolates from the adenoid and lateral wall of the nose in children undergoing adenoidectomy: implications in acute rhinosinusitis. Bernstein, J.M., Dryja, D., Murphy, T.F. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2001) [Pubmed]
  20. Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle. Winkler, M.T., Doster, A., Jones, C. J. Virol. (1999) [Pubmed]
  21. Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli. Lowman, M.A., Rees, P.H., Benyon, R.C., Church, M.K. J. Allergy Clin. Immunol. (1988) [Pubmed]
  22. Cleavage of influenza a virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases. Zhirnov, O.P., Ikizler, M.R., Wright, P.F. J. Virol. (2002) [Pubmed]
  23. Differences in effect of isoproterenol stimulation on levels of cyclic AMP in human B and T lymphocytes. Niaudet, P., Beaurain, G., Bach, M.A. Eur. J. Immunol. (1976) [Pubmed]
  24. Immunohistochemical expression of cytokeratins 7 and 20 in malignant salivary gland tumors. Nikitakis, N.G., Tosios, K.I., Papanikolaou, V.S., Rivera, H., Papanicolaou, S.I., Ioffe, O.B. Mod. Pathol. (2004) [Pubmed]
  25. Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4. Banwell, M.E., Robinson, D.S., Lloyd, C.M. J. Allergy Clin. Immunol. (2003) [Pubmed]
  26. Penetration of cefprozil into tonsillar and adenoidal tissues. Shyu, W.C., Reilly, J., Campbell, D.A., Wilber, R.B., Barbhaiya, R.H. Antimicrob. Agents Chemother. (1993) [Pubmed]
  27. Immunohistochemical study of overexpression of fibroblast growth factor-1 (FGF-1), FGF-2, and FGF receptor-1 in human malignant salivary gland tumours. Myoken, Y., Myoken, Y., Okamoto, T., Sato, J.D., Kan, M., McKeehan, W.L., Nakahara, M., Takada, K. J. Pathol. (1996) [Pubmed]
  28. Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH. Jin, C., Martins, C., Jin, Y., Wiegant, J., Wennerberg, J., Dictor, M., Gisselsson, D., Strömbeck, B., Fonseca, I., Mitelman, F., Tanke, H.J., Höglund, M., Mertens, F. Genes Chromosomes Cancer (2001) [Pubmed]
  29. High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid. Zetterström, C.K., Bergman, T., Rynnel-Dagöö, B., Erlandsson Harris, H., Soder, O., Andersson, U., Boman, H.G. Pediatr. Res. (2002) [Pubmed]
  30. KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Azoulay, S., Laé, M., Fréneaux, P., Merle, S., Al Ghuzlan, A., Chnecker, C., Rosty, C., Klijanienko, J., Sigal-Zafrani, B., Salmon, R., Fourquet, A., Sastre-Garau, X., Vincent-Salomon, A. Mod. Pathol. (2005) [Pubmed]
  31. Overexpression of SCC antigen and cyclins in an adenoid squamous carcinoma cell line derived from the maxillary sinus. Kishimoto, H., Urade, M., Hashimoto-Tamaoki, T., Furuyama, J.I. Int. J. Oncol. (2001) [Pubmed]
  32. Effect of dirithromycin on Haemophilus influenzae infection of the respiratory mucosa. Rutman, A., Dowling, R., Wills, P., Feldman, C., Cole, P.J., Wilson, R. Antimicrob. Agents Chemother. (1998) [Pubmed]
  33. Treatment of primary tracheal carcinoma. The role of external and endoluminal radiotherapy. Harms, W., Latz, D., Becker, H., Gagel, B., Herth, F., Wannenmacher, M. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (2000) [Pubmed]
  34. Isolation and identification of an alpha 2 subclass lymphotoxin (LT) subunit from the high-molecular-weight (complex) human LT class. Devlin, J.J., Klostergaard, J., Granger, G.A. Cell. Immunol. (1984) [Pubmed]
  35. The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media. Collins, M.P., Church, M.K. Current medical research and opinion. (1983) [Pubmed]
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