Gene Review:
CYLD - cylindromatosis (turban tumor syndrome)
Homo sapiens
Synonyms:
BRSS, CDMT, CYLD1, CYLDI, Deubiquitinating enzyme CYLD, ...
- The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. Regamey, A., Hohl, D., Liu, J.W., Roger, T., Kogerman, P., Toftgard, R., Huber, M. J. Exp. Med. (2003)
- Reduced expression of CYLD in human colon and hepatocellular carcinomas. Hellerbrand, C., Bumes, E., Bataille, F., Dietmaier, W., Massoumi, R., Bosserhoff, A.K. Carcinogenesis (2007)
- Carcinosarcoma arising in a patient with multiple cylindromas. De Francesco, V., Frattasio, A., Pillon, B., Stinco, G., Scott, C.A., Trotter, D., Patrone, P. The American Journal of dermatopathology. (2005)
- Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm. Ströbel, P., Zettl, A., Ren, Z., Starostik, P., Riedmiller, H., Störkel, S., Müller-Hermelink, H.K., Marx, A. Am. J. Surg. Pathol. (2002)
- The tumor suppressor CYLD regulates entry into mitosis. Stegmeier, F., Sowa, M.E., Nalepa, G., Gygi, S.P., Harper, J.W., Elledge, S.J. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Massoumi, R., Chmielarska, K., Hennecke, K., Pfeifer, A., Fässler, R. Cell (2006)
- Identification of the familial cylindromatosis tumour-suppressor gene. Bignell, G.R., Warren, W., Seal, S., Takahashi, M., Rapley, E., Barfoot, R., Green, H., Brown, C., Biggs, P.J., Lakhani, S.R., Jones, C., Hansen, J., Blair, E., Hofmann, B., Siebert, R., Turner, G., Evans, D.G., Schrander-Stumpel, C., Beemer, F.A., van Den Ouweland, A., Halley, D., Delpech, B., Cleveland, M.G., Leigh, I., Leisti, J., Rasmussen, S. Nat. Genet. (2000)
- Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Reiley, W., Zhang, M., Wu, X., Granger, E., Sun, S.C. Mol. Cell. Biol. (2005)
- Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Brummelkamp, T.R., Nijman, S.M., Dirac, A.M., Bernards, R. Nature (2003)
- Conventional and array-based comparative genomic hybridization analyses of novel cell lines harboring HPV18 from glassy cell carcinoma of the uterine cervix. Hirai, Y., Kawamata, Y., Takeshima, N., Furuta, R., Kitagawa, T., Kawaguchi, T., Hasumi, K., Sugai, S., Noda, T. Int. J. Oncol. (2004)
- Regulation of T cell development by the deubiquitinating enzyme CYLD. Reiley, W.W., Zhang, M., Jin, W., Losiewicz, M., Donohue, K.B., Norbury, C.C., Sun, S.C. Nat. Immunol. (2006)
- The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. Saito, K., Kigawa, T., Koshiba, S., Sato, K., Matsuo, Y., Sakamoto, A., Takagi, T., Shirouzu, M., Yabuki, T., Nunokawa, E., Seki, E., Matsuda, T., Aoki, M., Miyata, Y., Hirakawa, N., Inoue, M., Terada, T., Nagase, T., Kikuno, R., Nakayama, M., Ohara, O., Tanaka, A., Yokoyama, S. Structure (Camb.) (2004)
- Negative regulation of JNK signaling by the tumor suppressor CYLD. Reiley, W., Zhang, M., Sun, S.C. J. Biol. Chem. (2004)
- Reversible and irreversible inhibition of phosphate transport in human erythrocytes by a membrane impermeant carbodiimide. Craik, J.D., Reithmeier, R.A. J. Biol. Chem. (1985)
- A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines. Kamiński, Z.J., Kolesińska, B., Kamińska, J.E., Góra, J. J. Org. Chem. (2001)
- TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Stokes, A., Wakano, C., Koblan-Huberson, M., Adra, C.N., Fleig, A., Turner, H. Cell. Signal. (2006)
- CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A., Mosialos, G. Nature (2003)
- The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israël, A., Wallach, D., Courtois, G. Nature (2003)
- Diverse phenotype of Brooke-Spiegler syndrome associated with a nonsense mutation in the CYLD tumor suppressor gene. Zhang, G., Huang, Y., Yan, K., Li, W., Fan, X., Liang, Y., Sun, L., Li, H., Zhang, S., Gao, M., Du, W., Yang, S., Liu, J., Zhang, X. Exp. Dermatol. (2006)
- Small RNA: can RNA interference be exploited for therapy? Wall, N.R., Shi, Y. Lancet (2003)
- Differentiation between benign and malignant human lymph nodes by means of immunologic markers. Brubaker, D.B., Whiteside, T.L. Cancer (1979)