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MeSH Review

Pharyngeal Neoplasms

 
 
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Disease relevance of Pharyngeal Neoplasms

 

High impact information on Pharyngeal Neoplasms

 

Chemical compound and disease context of Pharyngeal Neoplasms

 

Biological context of Pharyngeal Neoplasms

 

Anatomical context of Pharyngeal Neoplasms

  • Cytochrome P4501A1 (CYP1A1) and the UDP-glucuronosyltransferase isoform UGT1A6 were studied in pharyngeal mucosa and squamous cancer tissue obtained from 27 male subjects (10 healthy nonsmoking volunteers, 10 smokers, and 7 smokers with pharyngeal cancer) [15].
 

Gene context of Pharyngeal Neoplasms

  • A specific kinase inhibitor to PIK3CA may potentially be an effective therapeutic reagent against HNSCC or pharyngeal cancer in particular [16].
  • The XRCC2 His-allele was associated with a significantly increased risk of pharyngeal cancer (OR=2.9, 95% CI: 1.3-6.2) [17].
  • The risk associated with the CYP2E1 RsaI c2 variant allele also increased for oral cavity/pharyngeal cancer (OR = 2.6, 95% CI 1.0-6. 6). The effects of ADH(3) or CYP2E1 genotype and alcohol or tobacco were independent [18].
  • Thirty-two cases (15.8%) and 46 controls (10.8%) were homozygous for the XRCC1 28152 A allele [adjusted OR = 1.59 (CI, 0.97-2.61) for all cases, and 1.41 (CI, 0. 80-2.48) for oral and pharyngeal cancer only] [19].
  • EGFR determination appears to be a powerful prognostic parameter in unresectable pharyngeal cancer patients treated by concomitant chemo-radiotherapy [20].
 

Analytical, diagnostic and therapeutic context of Pharyngeal Neoplasms

References

  1. Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma. Morita, S., Yano, M., Tsujinaka, T., Akiyama, Y., Taniguchi, M., Kaneko, K., Miki, H., Fujii, T., Yoshino, K., Kusuoka, H., Monden, M. Int. J. Cancer (1999) [Pubmed]
  2. Folate intake and risk of oral and pharyngeal cancer. Pelucchi, C., Talamini, R., Negri, E., Levi, F., Conti, E., Franceschi, S., La Vecchia, C. Ann. Oncol. (2003) [Pubmed]
  3. Attributable risk for oral cancer in northern Italy. Negri, E., La Vecchia, C., Franceschi, S., Tavani, A. Cancer Epidemiol. Biomarkers Prev. (1993) [Pubmed]
  4. Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde. Marsh, G.M., Youk, A.O., Buchanich, J.M., Cassidy, L.D., Lucas, L.J., Esmen, N.A., Gathuru, I.M. Toxicology and industrial health. (2002) [Pubmed]
  5. Re: Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. Bouchardy, C., Coutelle, C., Ward, P.J., Dayer, P., Benhamou, S. J. Natl. Cancer Inst. (1998) [Pubmed]
  6. Dietary factors in oral and pharyngeal cancer. McLaughlin, J.K., Gridley, G., Block, G., Winn, D.M., Preston-Martin, S., Schoenberg, J.B., Greenberg, R.S., Stemhagen, A., Austin, D.F., Ershow, A.G. J. Natl. Cancer Inst. (1988) [Pubmed]
  7. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Zheng, W., Blot, W.J., Diamond, E.L., Norkus, E.P., Spate, V., Morris, J.S., Comstock, G.W. Cancer Res. (1993) [Pubmed]
  8. Diet in the etiology of oral and pharyngeal cancer among women from the southern United States. Winn, D.M., Ziegler, R.G., Pickle, L.W., Gridley, G., Blot, W.J., Hoover, R.N. Cancer Res. (1984) [Pubmed]
  9. Estimating dose-response relationship between ethanol and risk of cancer using regression spline models. Polesel, J., Dal Maso, L., Bagnardi, V., Zucchetto, A., Zambon, A., Levi, F., La Vecchia, C., Franceschi, S. Int. J. Cancer (2005) [Pubmed]
  10. Diet and pharyngeal cancer. Rossing, M.A., Vaughan, T.L., McKnight, B. Int. J. Cancer (1989) [Pubmed]
  11. Vitamin supplement use and reduced risk of oral and pharyngeal cancer. Gridley, G., McLaughlin, J.K., Block, G., Blot, W.J., Gluch, M., Fraumeni, J.F. Am. J. Epidemiol. (1992) [Pubmed]
  12. Use of mentholated cigarettes and oropharyngeal cancer. Kabat, G.C., Hebert, J.R. Epidemiology (Cambridge, Mass.) (1994) [Pubmed]
  13. Dietary glutathione intake and the risk of oral and pharyngeal cancer. Flagg, E.W., Coates, R.J., Jones, D.P., Byers, T.E., Greenberg, R.S., Gridley, G., McLaughlin, J.K., Blot, W.J., Haber, M., Preston-Martin, S. Am. J. Epidemiol. (1994) [Pubmed]
  14. Analysis of heat-shock related gene expression in head-and-neck cancer using cDNA arrays. Narita, N., Noda, I., Ohtsubo, T., Fujieda, S., Tokuriki, M., Saito, T., Saito, H. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  15. Drug-metabolizing enzymes in pharyngeal mucosa and in oropharyngeal cancer tissue. Ullrich, D., Münzel, P.A., Beck-Gschaidmeier, S., Schröder, M., Bock, K.W. Biochem. Pharmacol. (1997) [Pubmed]
  16. PIK3CA mutations in head and neck squamous cell carcinoma. Qiu, W., Schönleben, F., Li, X., Ho, D.J., Close, L.G., Manolidis, S., Bennett, B.P., Su, G.H. Clin. Cancer Res. (2006) [Pubmed]
  17. DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. Benhamou, S., Tuimala, J., Bouchardy, C., Dayer, P., Sarasin, A., Hirvonen, A. Int. J. Cancer (2004) [Pubmed]
  18. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Bouchardy, C., Hirvonen, A., Coutelle, C., Ward, P.J., Dayer, P., Benhamou, S. Int. J. Cancer (2000) [Pubmed]
  19. Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. Sturgis, E.M., Castillo, E.J., Li, L., Zheng, R., Eicher, S.A., Clayman, G.L., Strom, S.S., Spitz, M.R., Wei, Q. Carcinogenesis (1999) [Pubmed]
  20. The relationship of epidermal growth factor receptor levels to the prognosis of unresectable pharyngeal cancer patients treated by chemo-radiotherapy. Magné, N., Pivot, X., Bensadoun, R.J., Guardiola, E., Poissonnet, G., Dassonville, O., Francoual, M., Formento, J.L., Demard, F., Schneider, M., Milano, G. Eur. J. Cancer (2001) [Pubmed]
  21. p53 expression in locally advanced pharyngeal squamous cell carcinoma. Lassaletta, L., Brandáriz, J.A., Benito, A., de la Cruz, J., Gómez, C., Ballestín, C., Hitt, R., Colomer, R., Alvarez-Vicent, J.J. Arch. Otolaryngol. Head Neck Surg. (1999) [Pubmed]
 
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