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MeSH Review

Vitamin K Deficiency

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Disease relevance of Vitamin K Deficiency


High impact information on Vitamin K Deficiency


Chemical compound and disease context of Vitamin K Deficiency


Biological context of Vitamin K Deficiency


Anatomical context of Vitamin K Deficiency

  • It is proposed that (1) the facial features of the human warfarin embryopathy are caused by reduced growth of the embryonic nasal septum, and (2) the septal growth retardation occurs because the warfarin-induced extrahepatic vitamin K deficiency prevents the normal formation of the vitamin K-dependent matrix gla protein in the embryo [19].

Gene context of Vitamin K Deficiency


Analytical, diagnostic and therapeutic context of Vitamin K Deficiency


  1. Intravascular coagulation with use of human prothrombin complex concentrates. Cederbaum, A.I., Blatt, P.M., Roberts, H.R. Ann. Intern. Med. (1976) [Pubmed]
  2. Skin necrosis and protein C deficiency associated with vitamin K depletion in a patient with renal failure. Soundararajan, R., Leehey, D.J., Yu, A.W., Ing, T.S., Miller, J.B. Am. J. Med. (1992) [Pubmed]
  3. Systemic causes of excessive uterine bleeding. Lusher, J.M. Semin. Hematol. (1999) [Pubmed]
  4. Treatment of vitamin K deficiency in cystic fibrosis: Effectiveness of a daily fat-soluble vitamin combination. Wilson, D.C., Rashid, M., Durie, P.R., Tsang, A., Kalnins, D., Andrew, M., Corey, M., Shin, J., Tullis, E., Pencharz, P.B. J. Pediatr. (2001) [Pubmed]
  5. Syndromic paucity of the intrahepatic bile ducts: diagnostic difficulty; severe morbidity throughout early childhood. Deprettere, A., Portmann, B., Mowat, A.P. J. Pediatr. Gastroenterol. Nutr. (1987) [Pubmed]
  6. Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice. Israels, L.G., Walls, G.A., Ollmann, D.J., Friesen, E., Israels, E.D. J. Clin. Invest. (1983) [Pubmed]
  7. A new method to assay des-gamma-carboxyprothrombin. Results obtained in 75 cases of hepatocellular carcinoma. Soulier, J.P., Gozin, D., Lefrere, J.J. Gastroenterology (1986) [Pubmed]
  8. Gastrointestinal bleeding due to vitamin K deficiency in patients on parenteral cefamandole. Hooper, C.A., Haney, B.B., Stone, H.H. Lancet (1980) [Pubmed]
  9. Heparin-like inhibitor, not vitamin-K deficiency, in the newborn. van Doorm, J.M., Muller, A.D., Hemker, H.C. Lancet (1977) [Pubmed]
  10. The acquired vitamin K-dependent gamma-carboxylation deficiency in hepatocellular carcinoma involves not only prothrombin, but also protein C. Yoshikawa, Y., Sakata, Y., Toda, G., Oka, H. Hepatology (1988) [Pubmed]
  11. Vitamin D dependence of a calcium-binding protein containing gamma-carboxyglutamic acid in chicken bone. Hauschka, P.V., Reid, M.L. J. Biol. Chem. (1978) [Pubmed]
  12. Vitamin K concentrations in the plasma and liver of surgical patients. Usui, Y., Tanimura, H., Nishimura, N., Kobayashi, N., Okanoue, T., Ozawa, K. Am. J. Clin. Nutr. (1990) [Pubmed]
  13. The prevalence of vitamin K deficiency in chronic gastrointestinal disorders. Krasinski, S.D., Russell, R.M., Furie, B.C., Kruger, S.F., Jacques, P.F., Furie, B. Am. J. Clin. Nutr. (1985) [Pubmed]
  14. Prothrombin synthesis in rat hepatoma H4IIEC3 cells: response to the proposed "coagulopoietin factor". Shah, D.V., Engelke, J.A., Suttie, J.W. Thromb. Haemost. (1993) [Pubmed]
  15. Tolerance and safety of vitamin E: a toxicological position report. Kappus, H., Diplock, A.T. Free Radic. Biol. Med. (1992) [Pubmed]
  16. Vitamin K1 increases sister chromatid exchange in vitro in human leukocytes and in vivo in fetal sheep cells: a possible role for "vitamin K deficiency" in the fetus. Israels, L.G., Friesen, E., Jansen, A.H., Israels, E.D. Pediatr. Res. (1987) [Pubmed]
  17. Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. Pereira, S.P., Shearer, M.J., Williams, R., Mieli-Vergani, G. Archives of disease in childhood. Fetal and neonatal edition. (2003) [Pubmed]
  18. Increased warfarin sensitivity as an early manifestation of occult prostate cancer with chronic disseminated intravascular coagulation. Munter, G., Hershko, C. Acta Haematol. (2001) [Pubmed]
  19. The warfarin embryopathy: a rat model showing maxillonasal hypoplasia and other skeletal disturbances. Howe, A.M., Webster, W.S. Teratology (1992) [Pubmed]
  20. Relationship between vitamin K dependent coagulation factors and anticoagulants (protein C and protein S) in neonatal vitamin K deficiency. Matsuzaka, T., Tanaka, H., Fukuda, M., Aoki, M., Tsuji, Y., Kondoh, H. Arch. Dis. Child. (1993) [Pubmed]
  21. Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy. Wallin, R., Wajih, N., Greenwood, G.T., Sane, D.C. Medicinal research reviews. (2001) [Pubmed]
  22. Effects of vitamin K2 on osteoporosis. Iwamoto, J., Takeda, T., Sato, Y. Curr. Pharm. Des. (2004) [Pubmed]
  23. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2',4,4',5,5'-hexachlorobiphenyl on vitamin K-dependent blood coagulation in male and female WAG/Rij-rats. Bouwman, C.A., Van Dam, E., Fase, K.M., Koppe, J.G., Seinen, W., Thijssen, H.H., Vermeer, C., Van den Berg, M. Chemosphere (1999) [Pubmed]
  24. Prevalence of vitamin K deficiency in cystic fibrosis. Rashid, M., Durie, P., Andrew, M., Kalnins, D., Shin, J., Corey, M., Tullis, E., Pencharz, P.B. Am. J. Clin. Nutr. (1999) [Pubmed]
  25. Vitamin K deficiency in children pre-bone marrow transplantation. Barron, M.A., Doyle, J., Zlotkin, S. Bone Marrow Transplant. (2006) [Pubmed]
  26. Maternal total parenteral nutrition and fetal subdural hematoma. Sakai, M., Yoneda, S., Sasaki, Y., Saito, S. Obstetrics and gynecology. (2003) [Pubmed]
  27. The prevalence of coagulation abnormalities in hospitalized patients receiving lipid-based parenteral nutrition. Duerksen, D.R., Papineau, N. JPEN. Journal of parenteral and enteral nutrition. (2004) [Pubmed]
  28. Effect of oral water soluble vitamin K on PIVKA-II levels in newborns. Sharma, R.K., Marwaha, N., Kumar, P., Narang, A. Indian pediatrics. (1995) [Pubmed]
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