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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nasal Septum

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Disease relevance of Nasal Septum


Psychiatry related information on Nasal Septum

  • Surgical deafferentation of the olfactory bulbs from all the known chemosensory systems of the nasal septum renders rats anosmic, decreases sexual performance in copulation tests with females, and substantially reduces the frequency of NCE [4].

High impact information on Nasal Septum


Biological context of Nasal Septum

  • This paper reports changes in ciliary function following submucous resection of the nasal septum in 36 adult patients assessed by measuring mucociliary clearance time with a saccharine particle using the method described by Andersen et al [10].
  • Nasolabial embryogenesis can be best understood using the concept of embryonic fields in which midline structures (columella, philtrum, premaxilla, septum, vomer, and ethmoids) develop with paired, fused A fields [11].

Anatomical context of Nasal Septum


Associations of Nasal Septum with chemical compounds

  • The challenge consisted of unilaterally stimulating the nasal septum with diluent followed by three increasing doses of antigen and recording responses bilaterally [17].
  • The peptidyl diazomethane inactivator of cysteine endopeptidases, benzyloxycarbonyl-Tyr-Ala-CHN2, was tested as an inhibitor of interleukin 1 alpha-stimulated release of proteoglycan from bovine nasal septum cartilage explants [18].
  • The binding of d-tubocurarine di [methyl-14C] ether iodide (d-TCE) and other amines to bovine nasal septum, chondroitin sulfate (CS) and human plasma proteins was examined by equilibrium dialysis [19].
  • Bovine nasal septum and CS bound d-TCE to a greater extent than they did morphine, d-methadone (d-ME) and l-methadone (l-ME) [19].
  • It supports the hypothesis that warfarin interferes with the prenatal growth of the cartilaginous nasal septum by inhibiting the normal formation of a vitamin K-dependent protein that prevents calcification of cartilage [20].

Gene context of Nasal Septum

  • However, the number of neurons expressing LHRH mRNA in the nasal septum area in animals exposed to ethanol on G10 or G11 was significantly less than the number in control animals (p < 0.05) [21].
  • We investigated the effects of PAL (protocatechualdehyde), a metabolite of ACP (3,4-diacetoxy benzylidene diacetate) which is a candidate as a novel antirheumatic agent, on the production of a tissue inhibitor of metalloproteinases (TIMP) using a primary chondrocyte culture from bovine nasal septum cartilage [22].
  • While in the nasal septum, GnRH neurons migrate only within the confines of the olfactory and vomeronasal axonal fascicles [23].
  • This grid of recording sites extended over most of the surface of the olfactory epithelium on the nasal septum [24].
  • Complete freedom from symptoms was found in 29.7% of patients treated for varicose veins, 24.1% of patients with meniscus repair, and in only 10.6% of patients with nasal septum deviation [25].

Analytical, diagnostic and therapeutic context of Nasal Septum


  1. Reactive vascular lesion of nasal septum simulating angiosarcoma in a cocaine abuser. Alameda, F., Fontane, J., Corominas, J.M., Lloreta, J., Serrano, S. Hum. Pathol. (2000) [Pubmed]
  2. Squamous cell carcinoma of the nasal septum with Wegener's granulomatosis treated with cyclophosphamide and corticosteroids. Wakisaka, N., Tanaka, S., Nagayama, I., Furukawa, M. Auris, nasus, larynx. (1998) [Pubmed]
  3. Saethre-Chotzen syndrome: a clinical, EEG and neuroradiological study. Elia, M., Musumeci, S.A., Ferri, R., Greco, D., Romano, C., Del Gracco, S., Stefanini, M.C. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1996) [Pubmed]
  4. Deafferentation of the olfactory bulbs of male rats reduces erection to remote cues from females. Edwards, D.A., Davis, A.B. Physiol. Behav. (1997) [Pubmed]
  5. Origin of luteinizing hormone-releasing hormone neurons. Schwanzel-Fukuda, M., Pfaff, D.W. Nature (1989) [Pubmed]
  6. Delayed formation of proteoglycan aggregate structures in human articular cartilage disease states. Oegema, T.R. Nature (1980) [Pubmed]
  7. Aspiration of the nasal septum: a new complication of cocaine abuse. Libby, D.M., Klein, L., Altorki, N.K. Ann. Intern. Med. (1992) [Pubmed]
  8. Isolation and physical characterization of hyaluronic acid prepared from bovine nasal septum by cetylpyridinium chloride precipitation. Cleland, R.L., Sherblom, A.P. J. Biol. Chem. (1977) [Pubmed]
  9. GABAergic neurons in the embryonic olfactory pit/vomeronasal organ: maintenance of functional GABAergic synapses in olfactory explants. Wray, S., Fueshko, S.M., Kusano, K., Gainer, H. Dev. Biol. (1996) [Pubmed]
  10. The effect of submucous resection of the nasal septum on mucociliary transport and nasal airway. Barr, G.S. Clinical otolaryngology and allied sciences. (1989) [Pubmed]
  11. The spectrum of minimal clefting: process-oriented cleft management in the presence of an intact alveolus. Carstens, M.H. The Journal of craniofacial surgery. (2000) [Pubmed]
  12. Isolation and characterization of high-buoyant-density proteoglycans from bovine femoral-head cartilage. Lyon, M., Greenwood, J., Sheehan, J.K., Nieduszynski, I.A. Biochem. J. (1983) [Pubmed]
  13. Mucosal inherent activity patterns in the rat: evidence from voltage-sensitive dyes. Youngentob, S.L., Kent, P.F., Sheehe, P.R., Schwob, J.E., Tzoumaka, E. J. Neurophysiol. (1995) [Pubmed]
  14. Comparison of tracheal and nasal chondrocytes for tissue engineering of the trachea. Kojima, K., Bonassar, L.J., Ignotz, R.A., Syed, K., Cortiella, J., Vacanti, C.A. Ann. Thorac. Surg. (2003) [Pubmed]
  15. Delayed epistaxis resulting from external carotid artery injury requiring embolization: a rare complication of transsphenoidal surgery: case report. Cockroft, K.M., Carew, J.F., Trost, D., Fraser, R.A. Neurosurgery (2000) [Pubmed]
  16. Brain grafts of migratory GnRH cells induce gonadal recovery in hypogonadal (hpg) mice. Livne, I., Gibson, M.J., Silverman, A.J. Brain Res. Dev. Brain Res. (1992) [Pubmed]
  17. Physiologic responses and histamine release after nasal antigen challenge. Effect of atropine. Baroody, F.M., Ford, S., Lichtenstein, L.M., Kagey-Sobotka, A., Naclerio, R.M. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  18. Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation. Buttle, D.J., Saklatvala, J. Biochem. J. (1992) [Pubmed]
  19. Binding of d-tubocurarine di (methyl-14C) ether iodide and other amines to cartilage, chondroitin sulfate and human plasma proteins. Olsen, G.D., Chan, E.M., Riker, W.K. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  20. Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure. Howe, A.M., Lipson, A.H., de Silva, M., Ouvrier, R., Webster, W.S. Am. J. Med. Genet. (1997) [Pubmed]
  21. Acute prenatal ethanol exposure and luteinizing hormone-releasing hormone messenger RNA expression in the fetal mouse brain. Scott, H.C., Zoeller, R.T., Rudeen, P.K. Alcohol. Clin. Exp. Res. (1995) [Pubmed]
  22. Effect of a benzylidene derivative, novel antirheumatic agent, on the production of tissue inhibitor of metalloproteinases. Watanabe, K., Hayashi, H., Mori, Y. Biol. Pharm. Bull. (1994) [Pubmed]
  23. Biochemical differentiation and intercellular interactions of migratory gonadotropin-releasing hormone (GnRH) cells in the mouse. Livne, I., Gibson, M.J., Silverman, A.J. Dev. Biol. (1993) [Pubmed]
  24. Topographic patterns of responsiveness to odorants in the rat olfactory epithelium. Mackay-Sim, A., Kesteven, S. J. Neurophysiol. (1994) [Pubmed]
  25. Hospital outcomes research in Germany: results from a retrospective survey among sickness fund beneficiaries. Bitzer, E.M., Dörning, H., Busse, R., Schwartz, F.W. Medical care. (1997) [Pubmed]
  26. Target tissue influences the peripheral trajectory of mouse primary sensory olfactory axons. Storan, M.J., Key, B. J. Neurobiol. (2004) [Pubmed]
  27. 2,5-Diarylisothiazolone: novel inhibitors of cytokine-induced cartilage destruction. Wright, S.W., Petraitis, J.J., Freimark, B., Giannaras, J.V., Pratta, M.A., Sherk, S.R., Williams, J.M., Magolda, R.L., Arner, E.C. Bioorg. Med. Chem. (1996) [Pubmed]
  28. Expression of human papillomavirus 6 in inverted papilloma arising in a renal transplant recipient. Harris, M.O., Beck, J.C., Terrell, J.E., McClatchey, K.D., Carey, T.E., Bradford, C.R. Laryngoscope (1998) [Pubmed]
  29. Cold exposure enhances nitroxidergic nerve-mediated vasodilatation in canine nasal mucosa. Watanabe, H., Tsuru, H., Yajin, K., Kawamoto, H., Sasa, M. Jpn. J. Pharmacol. (1998) [Pubmed]
  30. Mechanical properties of septal cartilage homografts. Glasgold, M.J., Kato, Y.P., Christiansen, D., Hauge, J.A., Glasgold, A.I., Silver, F.H. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1988) [Pubmed]
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