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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sacrococcygeal Region

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Disease relevance of Sacrococcygeal Region


High impact information on Sacrococcygeal Region

  • Decreased PKA activity causes dorsal expansion of Sonic hedgehog signal response in the thoracic to sacral regions correlating with the regions of morphological abnormalities [6].
  • In non-syndromic HD patients who do not have the SOX10 mutation, the SOX10 gene expressed in the sacral region may be involved in the pathogenesis of the abnormal nerve trunks through interaction with other factors [7].
  • Delay of retinol supplementation to E9.5 or later resulted in a marked increase in both occurrence and severity of skeletal malformations, extending from the craniocervical to sacral regions [8].
  • In the brachial and sacral regions, the majority of motoneurons express Gfra1 but only a minority express Gfra2 [9].
  • In all cases the autoradiograms demonstrated that neurotensin receptors were distributed in a similar fashion in the gray matter of the cervical, thoracic, lumbar, sacral and coccygeal regions of the human spinal cord [10].

Anatomical context of Sacrococcygeal Region


Associations of Sacrococcygeal Region with chemical compounds

  • Ketamine depressed the motor responses of the anococcygeus to stimulation of the pre-ganglionic lumbar sympathetic outflow or to stimulation of post-ganglionic fibres in the sacral region in a dose-dependent manner, the response to preganglionic stimulation being relatively more sensitive to such depression [14].
  • Binding of 125I-[Sar1.Ile8] Ang II is most prominent in the lateral horns of the thoracolumbar and sacral regions containing the sympathetic and parasympathetic preganglionic neurons respectively [15].
  • When injected with indigo carmine, the vessels localized by the hydrogen-induced current impulses filled the entire anterior spinal artery from the low thoracic to the sacral region, whereas injection of the other vessels did not show filling [16].
  • The sacral region was visualized in a coronal plane, when the fetus was in anterodorsal position [17].
  • X-ray showed a bony deformity of the sacrococcygeal region in the shape of a scimitar [18].

Gene context of Sacrococcygeal Region

  • Three cases of "dedifferentiated" chordoma arising in the sacrococcygeal region are presented [19].
  • Thoracic cord transection, however, resulted in significant increases of 7B2-IR in lumbar and especially sacral regions, providing evidence of a 7B2-containing ascending pathway originating in the lumbosacral spinal cord [20].

Analytical, diagnostic and therapeutic context of Sacrococcygeal Region


  1. Spina bifida occulta in epilepsy syndromes. Klepel, H., Freitag, G. Neurology (1992) [Pubmed]
  2. Changes in the distribution of laminin alpha1 chain in psoriatic skin: immunohistochemical study using confocal laser scanning microscopy. Vaccaro, M., Magaudda, L., Cutroneo, G., Trimarchi, F., Barbuzza, O., Guarneri, F., Guarneri, B. Br. J. Dermatol. (2002) [Pubmed]
  3. Primary retroperitoneal teratomas: a review of the literature. Gatcombe, H.G., Assikis, V., Kooby, D., Johnstone, P.A. Journal of surgical oncology. (2004) [Pubmed]
  4. Sacral medial telangiectatic vascular nevus: a study of 43 children. Patrizi, A., Neri, I., Orlandi, C., Marini, R. Dermatology (Basel) (1996) [Pubmed]
  5. Malignant fibrous histiocytoma in chordoma--immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma. Choi, Y.J., Kim, T.S. Yonsei Med. J. (1994) [Pubmed]
  6. Protein kinase A deficiency causes axially localized neural tube defects in mice. Huang, Y., Roelink, H., McKnight, G.S. J. Biol. Chem. (2002) [Pubmed]
  7. SOX10 is abnormally expressed in aganglionic bowel of Hirschsprung's disease infants. Sham, M.H., Lui, V.C., Fu, M., Chen, B., Tam, P.K. Gut (2001) [Pubmed]
  8. Vitamin A deficiency in the late gastrula stage rat embryo results in a one to two vertebral anteriorization that extends throughout the axial skeleton. Kaiser, M.E., Merrill, R.A., Stein, A.C., Breburda, E., Clagett-Dame, M. Dev. Biol. (2003) [Pubmed]
  9. Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2. Garcès, A., Livet, J., Grillet, N., Henderson, C.E., Delapeyrière, O. Dev. Dyn. (2001) [Pubmed]
  10. Neurotensin receptors in the human spinal cord: a quantitative autoradiographic study. Faull, R.L., Villiger, J.W., Dragunow, M. Neuroscience (1989) [Pubmed]
  11. Distribution and localization of neuromedin B-like immunoreactivity in pig, cat and rat spinal cord. Namba, M., Ghatei, M.A., Gibson, S.J., Polak, J.M., Bloom, S.R. Neuroscience (1985) [Pubmed]
  12. The effect of cisplatin dose and surgical resection in children with malignant germ cell tumors at the sacrococcygeal region: a pediatric intergroup trial (POG 9049/CCG 8882). Rescorla, F., Billmire, D., Stolar, C., Vinocur, C., Colombani, P., Cullen, J., Giller, R., Cushing, B., Lauer, S., Davis, M., Hawkins, E., Shuster, J., Krailo, M. J. Pediatr. Surg. (2001) [Pubmed]
  13. Sacral chordoma with unusual posterior radiographic presentation. Coombs, R.J., Coiner, L. Skeletal radiology. (1996) [Pubmed]
  14. Effects of ketamine on the peripheral autonomic nervous system of the rat. Clanachan, A.S., McGrath, J.C. Br. J. Pharmacol. (1976) [Pubmed]
  15. Distribution of angiotensin II receptor binding in the spinal cord of the sheep. Oldfield, B.J., Allen, A.M., Hards, D.K., McKinley, M.J., Schlawe, I., Mendelsohn, F.A. Brain Res. (1994) [Pubmed]
  16. Preliminary report of localization of spinal cord blood supply by hydrogen during aortic operations. Svensson, L.G., Patel, V., Coselli, J.S., Crawford, E.S. Ann. Thorac. Surg. (1990) [Pubmed]
  17. Ossification timing of sacral vertebrae by ultrasound in the mid-second trimester of pregnancy. De Biasio, P., Ginocchio, G., Aicardi, G., Ravera, G., Venturini, P.L., Vignolo, M. Prenat. Diagn. (2003) [Pubmed]
  18. Currarino syndrome associated with penoscrotal inversion and perineal fissure. Aslan, A., Karagüzel, G., Mihci, E., Melikoğlu, M. Pediatr. Surg. Int. (2005) [Pubmed]
  19. "Dedifferentiated" chordoma. A clinicopathologic and immunohistochemical study of three cases. Meis, J.M., Raymond, A.K., Evans, H.L., Charles, R.E., Giraldo, A.A. Am. J. Surg. Pathol. (1987) [Pubmed]
  20. Regional distribution of a novel pituitary protein (7B2) in the rat spinal cord: effect of neonatal capsaicin treatment and thoracic cord transection. Suzuki, H., Christofides, N.D., Anand, P., Chretien, M., Seidah, N.G., Polak, J.M., Bloom, S.R. Neurosci. Lett. (1985) [Pubmed]
  21. Cryosurgical treatment of sacrococcygeal chordoma. Report of four cases. de Vries, J., Oldhoff, J., Hadders, H.N. Cancer (1986) [Pubmed]
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