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Chemical Compound Review

CCRIS 2586     1-nitrosopyrene

Synonyms: AG-H-49575, AC1L2XHB, CTK3I9543, AR-1C4934, LS-129455, ...
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Disease relevance of CCRIS 2586


High impact information on CCRIS 2586


Chemical compound and disease context of CCRIS 2586

  • When the reducer column was introduced just after the separation column, 1-NP, 1-nitrosopyrene and 1-aminopyrene in the incubation mixture of 1-NP and the Salmonella typhimurium YG1021 strain were separately determined with detection limits as low as sub fmol levels [9].

Biological context of CCRIS 2586


Anatomical context of CCRIS 2586


Associations of CCRIS 2586 with other chemical compounds


Gene context of CCRIS 2586

  • In order to determine how this initial premutational lesion is converted to a stable heritable mutation, DNA sequences were determined for 30 mutations induced by 1-nitrosopyrene that mapped between bp 1 and 352 in the lambda cI gene of E.coli lysogens [5].

Analytical, diagnostic and therapeutic context of CCRIS 2586


  1. Effect of nucleotide excision repair in human cells on intrachromosomal homologous recombination induced by UV and 1-nitrosopyrene. Bhattacharyya, N.P., Maher, V.M., McCormick, J.J. Mol. Cell. Biol. (1990) [Pubmed]
  2. Comparative tumorigenicity of 1-nitropyrene, 1-nitrosopyrene, and 1-aminopyrene administered by gavage to Sprague-Dawley rats. el-Bayoumy, K., Rivenson, A., Johnson, B., DiBello, J., Little, P., Hecht, S.S. Cancer Res. (1988) [Pubmed]
  3. Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene. Fifer, E.K., Heflich, R.H., Djurić, Z., Howard, P.C., Beland, F.A. Carcinogenesis (1986) [Pubmed]
  4. Cytotoxicity, cellular transformation and DNA adducts in normal human diploid fibroblasts exposed to 1-nitrosopyrene, a reduced derivative of the environmental contaminant, 1-nitropyrene. Beland, F.A., Ribovich, M., Howard, P.C., Heflich, R.H., Kurian, P., Milo, G.E. Carcinogenesis (1986) [Pubmed]
  5. The mutagenicity and DNA base sequence changes induced by 1-nitroso- and 1-nitropyrene in the cI gene of lambda prophage. Stanton, C.A., Garner, R.C., Martin, C.N. Carcinogenesis (1988) [Pubmed]
  6. Site-specific excision repair of 1-nitrosopyrene-induced DNA adducts at the nucleotide level in the HPRT gene of human fibroblasts: effect of adduct conformation on the pattern of site-specific repair. Wei, D., Maher, V.M., McCormick, J.J. Mol. Cell. Biol. (1996) [Pubmed]
  7. Kinds and spectrum of mutations induced by 1-nitrosopyrene adducts during plasmid replication in human cells. Yang, J.L., Maher, V.M., McCormick, J.J. Mol. Cell. Biol. (1988) [Pubmed]
  8. DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells. Newton, R.K., Mittelstaedt, R.A., Manjanatha, M.G., Heflich, R.H. Carcinogenesis (1992) [Pubmed]
  9. An on-line reduction HPLC/chemiluminescence detection system for nitropolycyclic aromatic hydrocarbons and metabolites. Hayakawa, K., Terai, N., Dinning, P.G., Akutsu, K., Iwamoto, Y., Etoh, R., Murahashi, T. Biomed. Chromatogr. (1996) [Pubmed]
  10. Analysis of solvent control and 1-nitrosopyrene-induced Chinese hamster ovary cell mutants by Southern and northern blots and the polymerase chain reaction. Newton, R.K., Mittelstaedt, R.A., Heflich, R.H. Environ. Mol. Mutagen. (1992) [Pubmed]
  11. Relationships between the DNA adducts and the mutations and sister-chromatid exchanges produced in Chinese hamster ovary cells by N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene. Heflich, R.H., Morris, S.M., Beranek, D.T., McGarrity, L.J., Chen, J.J., Beland, F.A. Mutagenesis (1986) [Pubmed]
  12. Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase. McGregor, W.G., Maher, V.M., McCormick, J.J. Cancer Res. (1994) [Pubmed]
  13. Comparison of the in vitro and in vivo hepatic metabolism of the carcinogen 1-nitropyrene. Howard, P.C., Flammang, T.J., Beland, F.A. Carcinogenesis (1985) [Pubmed]
  14. Identification of two N2-deoxyguanosinyl DNA adducts upon nitroreduction of the environmental mutagen 1-nitropyrene. Herreno-Saenz, D., Evans, F.E., Beland, F.A., Fu, P.P. Chem. Res. Toxicol. (1995) [Pubmed]
  15. The induction of DNA adducts in mammalian cells exposed to 1-nitropyrene and its nitro-reduced derivatives. Edwards, M.J., Batmanghelich, S., Edwards, S., Parry, J.M., Smith, K. Mutagenesis (1986) [Pubmed]
  16. 1-Nitrosopyrene: an intermediate in the metabolic activation of 1-nitropyrene to a mutagen in Salmonella typhimurium TA1538. Heflich, R.H., Howard, P.C., Beland, F.A. Mutat. Res. (1985) [Pubmed]
  17. DNA adducts of nitropyrene detected by specific antibodies. Groopman, J.D. Research report (Health Effects Institute) (1987) [Pubmed]
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