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Chemical Compound Review

CHEMBL314422     N-(9H-fluoren-2- yl)hydroxylamine

Synonyms: CCRIS 1067, AG-J-36237, HSDB 2113, AC1Q7DJS, LS-77424, ...
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Disease relevance of N-Hydroxy-aminofluorene


High impact information on N-Hydroxy-aminofluorene


Biological context of N-Hydroxy-aminofluorene


Anatomical context of N-Hydroxy-aminofluorene


Associations of N-Hydroxy-aminofluorene with other chemical compounds


Gene context of N-Hydroxy-aminofluorene


Analytical, diagnostic and therapeutic context of N-Hydroxy-aminofluorene


  1. Mutagenicity of N-hydroxy-2-acetylaminofluorene and N-hydroxy-phenacetin and their respective deacetylated metabolites in nitroreductase deficient Salmonella TA98FR and TA100FR. Wirth, P.J., Alewood, P., Calder, I., Thorgeirsson, S.S. Carcinogenesis (1982) [Pubmed]
  2. By-pass of the major aminofluorene-DNA adduct during in vivo replication of single- and double-stranded phi X174 DNA treated with N-hydroxy-2-aminofluorene. Lutgerink, J.T., Retèl, J., Westra, J.G., Welling, M.C., Loman, H., Kriek, E. Carcinogenesis (1985) [Pubmed]
  3. Comparison of mutagenesis induced in single- and double-stranded M13 viral DNA by treatment with N-hydroxy-2-aminofluorene. Gupta, P.K., Lee, M.S., King, C.M. Carcinogenesis (1988) [Pubmed]
  4. The differential effect of benzamide upon the toxicity and mutations produced in Chinese hamster ovary cells by N-methyl nitrosourea, N-ethyl nitrosourea and N-hydroxy-2-aminofluorene. Heflich, R.H., Morris, S.M., White, G.L., Beland, F.A. Mutat. Res. (1985) [Pubmed]
  5. Induction of DNA repair synthesis in human urothelial cells by the N-hydroxy metabolites of carcinogenic arylamines. Wang, C.Y., Christensen, B., Zukowski, K., Morton, K.C., Lee, M.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  6. Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus. Hein, D.W., Doll, M.A., Gray, K., Rustan, T.D., Ferguson, R.J. Cancer Res. (1993) [Pubmed]
  7. Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity. Shinohara, A., Saito, K., Yamazoe, Y., Kamataki, T., Kato, R. Cancer Res. (1986) [Pubmed]
  8. Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA. Frederick, C.B., Mays, J.B., Ziegler, D.M., Guengerich, F.P., Kadlubar, F.F. Cancer Res. (1982) [Pubmed]
  9. Metabolism of N-hydroxy-2-acetylaminofluorene and N-hydroxy-2-aminofluorene by guinea pig liver microsomes. Razzouk, C., Batardy-Grégoire, M., Roberfroid, M. Cancer Res. (1982) [Pubmed]
  10. Acyltransferase-mediated binding of N-hydroxyarylamides to nucleic acids. Beland, F.A., Allaben, W.T., Evans, F.E. Cancer Res. (1980) [Pubmed]
  11. The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype. Flammang, T.J., Yamazoe, Y., Guengerich, F.P., Kadlubar, F.F. Carcinogenesis (1987) [Pubmed]
  12. Base pair substitution and frameshift mutagenesis induced by apurinic sites and two fluorene derivatives in a recA441 lexA (Def) strain. Granger-Schnarr, M. Mol. Gen. Genet. (1986) [Pubmed]
  13. Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol. Shinohara, A., Saito, K., Yamazoe, Y., Kamataki, T., Kato, R. Chem. Biol. Interact. (1986) [Pubmed]
  14. Activation of the carcinogens N-hydroxy-N-2-fluorenylbenzamide and N-hydroxy-N-2-fluorenylacetamide via deacylations and acetyl transfers by rat peritoneal serosa and liver. Ritter, C.L., Malejka-Giganti, D. Carcinogenesis (1994) [Pubmed]
  15. Oxidative activation of 2-aminofluorene by human red blood cell cytosol. Duverger-van Bogaert, M., Wiame, D., Stecca, C. Biochem. Pharmacol. (1992) [Pubmed]
  16. Metabolic activation in isolated rat hepatocytes. Casciano, D.A. SAAS Bull. Biochem. Biotechnol. (1990) [Pubmed]
  17. A mutational hot spot induced by N-hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells. Carothers, A.M., Urlaub, G., Mucha, J., Yuan, W., Chasin, L.A., Grunberger, D. Carcinogenesis (1993) [Pubmed]
  18. Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene. Guo, Z., Wagner, C.R., Hanna, P.E. Chem. Res. Toxicol. (2004) [Pubmed]
  19. 2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complex. Klöhn, P.C., Brandt, U., Neumann, H.G. FEBS Lett. (1996) [Pubmed]
  20. Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles. Ferguson, R.J., Doll, M.A., Rustan, T.D., Gray, K., Hein, D.W. Drug Metab. Dispos. (1994) [Pubmed]
  21. Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens. Salles, B., Lang, M.C., Freund, A.M., Paoletti, C., Daune, M., Fuchs, R.P. Nucleic Acids Res. (1983) [Pubmed]
  22. Recognition and repair of 2-aminofluorene- and 2-(acetylamino)fluorene-DNA adducts by UVRABC nuclease. Pierce, J.R., Case, R., Tang, M.S. Biochemistry (1989) [Pubmed]
  23. Oxidation-dependent inactivation of aryl sulfotransferase IV by primary N-hydroxy arylamines during in vitro assays. King, R.S., Duffel, M.W. Carcinogenesis (1997) [Pubmed]
  24. Mutagenicity of some N- and O-acyl derivatives of N-hydroxy-2-aminofluorene in V79 Chinese hamster cells. Kuroki, T., Bartsch, H. Cancer Lett. (1979) [Pubmed]
  25. Activation of some aromatic amines to mutagenic products by human red blood cell cytosol. Duverger-van Bogaert, M., Crutzen-Fayt, M.C., Stecca, C. Mutat. Res. (1991) [Pubmed]
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