The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CADOTRIL     benzyl2-[(2-benzyl-3- ethanoylsulfanyl...

Synonyms: REDOTIL, Tiorfan, Acetorphan, ZEDOTT, Racecadotril, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Racecadotril

  • METHODS: We treated 135 boys 3 to 35 months of age who had watery diarrhea of five days' duration or less with racecadotril (1.5 mg per kilogram of body weight orally every eight hours) or placebo, in addition to oral rehydration solution [1].
  • The median duration of diarrhea was significantly less (P<0.001) in the racecadotril group (28 hours regardless of rotavirus status) than in the placebo group (72 and 52 hours, respectively, for rotavirus-positive and rotavirus-negative patients) [1].
  • There was statistically no significant difference between acetorphan and placebo in respect of side effects, particularly constipation, which often accompanies the antidiarrhoeal activity of mu opioid receptor agonists this difference is attributable to the lack of antipropulsive activity of acetorphan in man [2].
  • Racecadotril was significantly more effective than placebo in randomised double-blind studies in adults or children with diarrhoea (of infectious origin or in adults with HIV infection) [3].
  • In contrast, in the loperamide group (1 mg/kg b.d., n = 4), the E. coli content of segment S1 and the E. coli ratio stomach:S1 were both significantly higher than with racecadotril or control (P = 0.04 and 0.005, respectively, for E. coli content; P = 0.05 and 0.03, respectively, for stomach:S1) [4].

Psychiatry related information on Racecadotril

  • In mice chronically treated with acetorphan, the antinociceptive activity of the compound was not modified markedly and no overt withdrawal symptom could be observed after either treatment interruption or administration of naloxone [5].

High impact information on Racecadotril


Chemical compound and disease context of Racecadotril


Biological context of Racecadotril


Anatomical context of Racecadotril


Associations of Racecadotril with other chemical compounds

  • The first cohort of 14 consecutive patients explored for the mechanism of diarrhea received acetorphan (a new enkephalinase inhibitor) 100 mg three times daily; the second 14-patient cohort received, in addition to acetorphan, loperamide 4 mg three times daily [18].
  • OBJECTIVE AND METHOD: The authors compared the effects of acetorphan, an enkephalinase inhibitor, with those of clonidine for the treatment of the opioid withdrawal syndrome [19].
  • 4. The enkephalin catabolism inhibitor acetorphan, by itself, produced no activity in this test at a dose of 10 mg kg(-1) (s.c.). However, at higher doses, acetorphan produced a linear dose-response relationship against acetic acid-induced abdominal constriction [20].
  • Parenteral acetorphan elicited a series of naloxone-reversible, opioid-like effects, most of which were described previously with intracerebral Thiorphan or other enkephalinase inhibitors [5].
  • Treatment with acetorphan, a parenterally-active enkephalinase inhibitor, given alone or in combination with carbaphethiol, completely prevented the rise in YGG triggered by noxious stimulation [21].

Gene context of Racecadotril

  • On the other hand, we failed to demonstrate a potentiation of META- or CLOM-induced analgesia by acetorphan, an inhibitor of 'enkephalinase.' We also failed to show a potentiation of Met5-enkephalin intracerebroventricularly injected by the two TCAs [22].

Analytical, diagnostic and therapeutic context of Racecadotril


  1. Racecadotril in the treatment of acute watery diarrhea in children. Salazar-Lindo, E., Santisteban-Ponce, J., Chea-Woo, E., Gutierrez, M. N. Engl. J. Med. (2000) [Pubmed]
  2. Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. Baumer, P., Danquechin Dorval, E., Bertrand, J., Vetel, J.M., Schwartz, J.C., Lecomte, J.M. Gut (1992) [Pubmed]
  3. Racecadotril. Matheson, A.J., Noble, S. Drugs (2000) [Pubmed]
  4. Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet. Duval-Iflah, Y., Berard, H., Baumer, P., Guillaume, P., Raibaud, P., Joulin, Y., Lecomte, J.M. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  5. Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor. Lecomte, J.M., Costentin, J., Vlaiculescu, A., Chaillet, P., Marcais-Collado, H., Llorens-Cortes, C., Leboyer, M., Schwartz, J.C. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  6. Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC by acetorphan. Gros, C., Souque, A., Schwartz, J.C., Duchier, J., Cournot, A., Baumer, P., Lecomte, J.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis. Lurie, A., Nadel, J.A., Roisman, G., Siney, H., Dusser, D.J. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  8. Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Fink, C.A., Carlson, J.E., McTaggart, P.A., Qiao, Y., Webb, R., Chatelain, R., Jeng, A.Y., Trapani, A.J. J. Med. Chem. (1996) [Pubmed]
  9. Comparison of racecadotril and loperamide in adults with acute diarrhoea. Vetel, J.M., Berard, H., Fretault, N., Lecomte, J.M. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  10. Racecadotril demonstrates intestinal antisecretory activity in vivo. Primi, M.P., Bueno, L., Baumer, P., Berard, H., Lecomte, J.M. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  11. Endogenous opioid peptides in the control of food intake in cats. Bado, A., Rozé, C., Lewin, M.J., Dubrasquet, M. Peptides (1989) [Pubmed]
  12. Inhibition of apomorphine-induced yawning and penile erection by neurotensin. Nouel, D., Costentin, J. Peptides (1991) [Pubmed]
  13. Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [D-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro. Adjroud, O. J. Reprod. Fertil. (1995) [Pubmed]
  14. Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal. Liberge, M., Rivière, P.M., Buéno, L. Life Sci. (1988) [Pubmed]
  15. Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan. Livingston, S.J., Sewell, R.D., Rooney, K.F., Smith, H.J. Psychopharmacology (Berl.) (1988) [Pubmed]
  16. In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF. Spillantini, M.G., Geppetti, P., Fanciullacci, M., Michelacci, S., Lecomte, J.M., Sicuteri, F. Eur. J. Pharmacol. (1986) [Pubmed]
  17. Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan, an enkephalinase inhibitor. Jivegård, L., Pollard, H., Moreau, J., Schwartz, J.C., Thune, A., Svanvik, J. Clin. Sci. (1989) [Pubmed]
  18. Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. Saliba, F., Hagipantelli, R., Misset, J.L., Bastian, G., Vassal, G., Bonnay, M., Herait, P., Cote, C., Mahjoubi, M., Mignard, D., Cvitkovic, E. J. Clin. Oncol. (1998) [Pubmed]
  19. Comparison of acetorphan with clonidine for opiate withdrawal symptoms. Hartmann, F., Poirier, M.F., Bourdel, M.C., Loo, H., Lecomte, J.M., Schwartz, J.C. The American journal of psychiatry. (1991) [Pubmed]
  20. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. Gray, A.M., Spencer, P.S., Sewell, R.D. Br. J. Pharmacol. (1998) [Pubmed]
  21. Changes in levels of the tripeptide Tyr-Gly-Gly as an index of enkephalin release in the spinal cord: effects of noxious stimuli and parenterally-active peptidase inhibitors. Llorens-Cortes, C., Gros, C., Schwartz, J.C., Clot, A.M., Le Bars, D. Peptides (1989) [Pubmed]
  22. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Michael-Titus, A., Costentin, J. Pain (1987) [Pubmed]
  23. Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial. Alam, N.H., Ashraf, H., Khan, W.A., Karim, M.M., Fuchs, G.J. Gut (2003) [Pubmed]
WikiGenes - Universities