Chemical Compound Review:
CADOTRIL benzyl2-[(2-benzyl-3- ethanoylsulfanyl...
Synonyms:
REDOTIL, Tiorfan, Acetorphan, ZEDOTT, Racecadotril, ...
- Racecadotril in the treatment of acute watery diarrhea in children. Salazar-Lindo, E., Santisteban-Ponce, J., Chea-Woo, E., Gutierrez, M. N. Engl. J. Med. (2000)
- Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. Baumer, P., Danquechin Dorval, E., Bertrand, J., Vetel, J.M., Schwartz, J.C., Lecomte, J.M. Gut (1992)
- Racecadotril. Matheson, A.J., Noble, S. Drugs (2000)
- Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet. Duval-Iflah, Y., Berard, H., Baumer, P., Guillaume, P., Raibaud, P., Joulin, Y., Lecomte, J.M. Aliment. Pharmacol. Ther. (1999)
- Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor. Lecomte, J.M., Costentin, J., Vlaiculescu, A., Chaillet, P., Marcais-Collado, H., Llorens-Cortes, C., Leboyer, M., Schwartz, J.C. J. Pharmacol. Exp. Ther. (1986)
- Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan. Gros, C., Souque, A., Schwartz, J.C., Duchier, J., Cournot, A., Baumer, P., Lecomte, J.M. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis. Lurie, A., Nadel, J.A., Roisman, G., Siney, H., Dusser, D.J. Am. J. Respir. Crit. Care Med. (1994)
- Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Fink, C.A., Carlson, J.E., McTaggart, P.A., Qiao, Y., Webb, R., Chatelain, R., Jeng, A.Y., Trapani, A.J. J. Med. Chem. (1996)
- Comparison of racecadotril and loperamide in adults with acute diarrhoea. Vetel, J.M., Berard, H., Fretault, N., Lecomte, J.M. Aliment. Pharmacol. Ther. (1999)
- Racecadotril demonstrates intestinal antisecretory activity in vivo. Primi, M.P., Bueno, L., Baumer, P., Berard, H., Lecomte, J.M. Aliment. Pharmacol. Ther. (1999)
- Endogenous opioid peptides in the control of food intake in cats. Bado, A., Rozé, C., Lewin, M.J., Dubrasquet, M. Peptides (1989)
- Inhibition of apomorphine-induced yawning and penile erection by neurotensin. Nouel, D., Costentin, J. Peptides (1991)
- Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [D-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro. Adjroud, O. J. Reprod. Fertil. (1995)
- Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal. Liberge, M., Rivière, P.M., Buéno, L. Life Sci. (1988)
- Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan. Livingston, S.J., Sewell, R.D., Rooney, K.F., Smith, H.J. Psychopharmacology (Berl.) (1988)
- In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF. Spillantini, M.G., Geppetti, P., Fanciullacci, M., Michelacci, S., Lecomte, J.M., Sicuteri, F. Eur. J. Pharmacol. (1986)
- Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan, an enkephalinase inhibitor. Jivegård, L., Pollard, H., Moreau, J., Schwartz, J.C., Thune, A., Svanvik, J. Clin. Sci. (1989)
- Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. Saliba, F., Hagipantelli, R., Misset, J.L., Bastian, G., Vassal, G., Bonnay, M., Herait, P., Cote, C., Mahjoubi, M., Mignard, D., Cvitkovic, E. J. Clin. Oncol. (1998)
- Comparison of acetorphan with clonidine for opiate withdrawal symptoms. Hartmann, F., Poirier, M.F., Bourdel, M.C., Loo, H., Lecomte, J.M., Schwartz, J.C. The American journal of psychiatry. (1991)
- The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. Gray, A.M., Spencer, P.S., Sewell, R.D. Br. J. Pharmacol. (1998)
- Changes in levels of the tripeptide Tyr-Gly-Gly as an index of enkephalin release in the spinal cord: effects of noxious stimuli and parenterally-active peptidase inhibitors. Llorens-Cortes, C., Gros, C., Schwartz, J.C., Clot, A.M., Le Bars, D. Peptides (1989)
- Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Michael-Titus, A., Costentin, J. Pain (1987)
- Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial. Alam, N.H., Ashraf, H., Khan, W.A., Karim, M.M., Fuchs, G.J. Gut (2003)