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Chemical Compound Review

Picumast HCl     7-[3-[4-[(4-chlorophenyl) methyl]piperazin...

Synonyms: NSC 298894, AC1L32UL, BM 15100, BM 15,100
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Disease relevance of 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethyl-4a,8a-dihydrochromen-2-one


High impact information on 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethyl-4a,8a-dihydrochromen-2-one


Biological context of 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethyl-4a,8a-dihydrochromen-2-one


Anatomical context of 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethyl-4a,8a-dihydrochromen-2-one


Associations of 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethyl-4a,8a-dihydrochromen-2-one with other chemical compounds


Analytical, diagnostic and therapeutic context of 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethyl-4a,8a-dihydrochromen-2-one


  1. A one-year double-blind clinical study of the efficacy and tolerability of picumast dihydrochloride versus ketotifen in patients with bronchial asthma. Slapke, J., Müller, S., Boerner, D. Arzneimittel-Forschung. (1989) [Pubmed]
  2. Double-blind controlled crossover study comparing the protective effect of picumast dihydrochloride versus placebo following nasal allergen challenge. Franke, W., Bachert, C., Messinger, D. Arzneimittel-Forschung. (1989) [Pubmed]
  3. Pharmacokinetics of picumast dihydrochloride in patients with liver cirrhosis. Neugebauer, G., Raedsch, R., Stiehl, A., Kaufmann, B., Besenfelder, E., Neubert, P., Walter-Sack, I. Arzneimittel-Forschung. (1989) [Pubmed]
  4. Metabolism of picumast after administration of picumast dihydrochloride and antiallergic activity of the main metabolites. Besenfelder, E., Neubert, P., Roesch, A., Schaumann, W., Wilhelms, O.H. Arzneimittel-Forschung. (1989) [Pubmed]
  5. Inhibition of immunological histamine release from guinea pig lungs and other organs by mepyramine, ketotifen, and picumast in vivo. Sekardi, L., Friedberg, K.D. Arzneimittel-Forschung. (1989) [Pubmed]
  6. Therapeutic options in ocular allergic disease. Hingorani, M., Lightman, S. Drugs (1995) [Pubmed]
  7. Picumast and mast cell function. Rösch, A., Schaumann, W., Wilhelms, O.H. Clin. Exp. Allergy (1991) [Pubmed]
  8. The effects of picumast on human eosinophil and neutrophil activation. Moqbel, R., Hartnell, A., Kay, A.B. Clin. Exp. Allergy (1991) [Pubmed]
  9. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Gigl, G., Hartweg, D., Sanchez-Delgado, E., Metz, G., Gietzen, K. Cell Calcium (1987) [Pubmed]
  10. Effect of picumast on histamine release from rat cardiac and peritoneal mast cells. Wan, B.Y., Peh, K.H., Assem, E.S. Agents Actions (1991) [Pubmed]
  11. Pharmacokinetics of picumast dihydrochloride and its active metabolites M1 and M2 in humans. Neugebauer, G., Wittenbrink-Dix, A.M., Woelke-Seidl, E., Kaufmann, B., Ponton, T., Dahmen, W., Mosberg, H., Nieder, N., Besenfelder, E. Arzneimittel-Forschung. (1989) [Pubmed]
  12. Pharmacokinetics of picumast after administration of 14C-picumast dihydrochloride in dogs, rats, rabbits and monkeys. Schaumann, W., Besenfelder, E., Boehm, E., Neubert, P., Roesch, A., Sterz, H. Arzneimittel-Forschung. (1989) [Pubmed]
  13. Study of potential kinetic interactions of picumast dihydrochloride and theophylline in vitro and after oral administration in man. Wittenbrink-Dix, A.M., Neugebauer, G., Fuhr, U., Neubert, P., Besenfelder, E., Woelke-Seidl, E., Harder, S., Staib, A.H. Arzneimittel-Forschung. (1989) [Pubmed]
  14. Lens safety study with Picumast dihydrochloride--a double masked study using the Scheimpflug method. Hockwin, O., Müller-Breitenkamp, U., Laser, H., Messinger, D., Goder, G., Meinel, U. Lens and eye toxicity research. (1990) [Pubmed]
  15. Antagonism of picumast and ketotifen against histamine, acetylcholine, LTC4, slow-reacting substance of anaphylaxis and barium chloride in the guinea pig ileum bioassay. Wilhelms, O.H. Int. Arch. Allergy Appl. Immunol. (1987) [Pubmed]
  16. A placebo-controlled comparison of the efficacy and tolerability of picumast dihydrochloride and terfenadine in patients with seasonal allergic rhinitis. Boerner, D., Metz, K., Eberhardt, R., Schürmann, W. Arzneimittel-Forschung. (1989) [Pubmed]
  17. Double-blind multicenter controlled clinical study comparing the efficacy of picumast dihydrochloride versus astemizole and placebo in patients with seasonal allergic rhinitis. Franke, W., Messinger, D. Arzneimittel-Forschung. (1989) [Pubmed]
  18. High performance liquid chromatographic determination of Picumast and two active metabolites in plasma using on-line sample preparation. Besenfelder, E. Biomed. Chromatogr. (1991) [Pubmed]
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