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Chemical Compound Review

Hisfedin     4-[4-(hydroxy-diphenyl- methyl)-1...

Synonyms: Ternadin, Triludan, Rapidal, Seldane, Teldane, ...
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Disease relevance of Seldane


Psychiatry related information on Seldane

  • Hydroxyzine, but not terfenadine, significantly prolonged both simple and choice reaction time (p less than or equal to 0.0001) [5].
  • Patients were given a brief neuropsychological test battery before and after double-blind treatment with terfenadine or placebo and completed a daily mood rating scale (Positive and Negative Affect Schedule) during the study [6].
  • No therapeutic benefit from terfenadine could be detected in terms of symptom amelioration, improved physical or social functioning, health perceptions, or mental health [7].
  • Terfenadine neither impairs psychomotor performance nor adversely affects subjective feelings, nor enhances the depressant effects of concomitantly administered alcohol or benzodiazepines [8].
  • These effects appear to be caused by different mechanisms, but both may have potentially dangerous consequences. while several of the newer antihistamines, such as terfenadine, have overcome the problem of sedation, it is also important to establish their propensity to cause psychomotor impairment [9].

High impact information on Seldane


Chemical compound and disease context of Seldane


Biological context of Seldane


Anatomical context of Seldane


Associations of Seldane with other chemical compounds


Gene context of Seldane


Analytical, diagnostic and therapeutic context of Seldane

  • To elucidate possible mechanisms underlying the cardiotoxicity of terfenadine, the effect of this antihistamine on L-type Ca2+ channel current (ICa,L) was studied in adult rat ventricular myocytes using the whole-cell patch-clamp technique [4].
  • Patients were then included into a double-blind, randomized, 2-way crossover study to receive terfenadine or fexofenadine 120 mg 2 hours before provocation [13].
  • In a separate randomized double-blind study we have also examined the effect of an orally administered antihistamine, terfenadine, on kinin-induced wheal and flare responses and their repeatability in a group of nine volunteers [30].
  • The incidence of ECG rhythm abnormalities was not significantly higher in any treatment group; however, the incidence of prolongation of QTc > 10% above baseline was significantly higher in the groups treated with terfenadine [31].
  • The 300 mg bid terfenadine regimen produced significantly greater skin test suppression (p less than 0.05) than the currently recommended 60 mg bid dose [32].


  1. Cardiac actions of antihistamines. Woosley, R.L. Annu. Rev. Pharmacol. Toxicol. (1996) [Pubmed]
  2. Torsades de pointes occurring in association with terfenadine use. Mathews, D.R., McNutt, B., Okerholm, R., Flicker, M., McBride, G. JAMA (1991) [Pubmed]
  3. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Roy, M., Dumaine, R., Brown, A.M. Circulation (1996) [Pubmed]
  4. Inhibition of L-type Ca2+ channel current in rat ventricular myocytes by terfenadine. Liu, S., Melchert, R.B., Kennedy, R.H. Circ. Res. (1997) [Pubmed]
  5. Prolongation of simple and choice reaction times in a double-blind comparison of twice-daily hydroxyzine versus terfenadine. Goetz, D.W., Jacobson, J.M., Murnane, J.E., Reid, M.J., Repperger, D.W., Goodyear, C., Martin, M.E. J. Allergy Clin. Immunol. (1989) [Pubmed]
  6. An assessment of cognitive function and mood in chronic fatigue syndrome. Marshall, P.S., Watson, D., Steinberg, P., Cornblatt, B., Peterson, P.K., Callies, A., Schenck, C.H. Biol. Psychiatry (1996) [Pubmed]
  7. Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome. Steinberg, P., McNutt, B.E., Marshall, P., Schenck, C., Lurie, N., Pheley, A., Peterson, P.K. J. Allergy Clin. Immunol. (1996) [Pubmed]
  8. Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy. Sorkin, E.M., Heel, R.C. Drugs (1985) [Pubmed]
  9. Effects of terfenadine on psychomotor performance. An overview. Aaronson, D.W. Drug safety : an international journal of medical toxicology and drug experience. (1993) [Pubmed]
  10. Mechanism of the cardiotoxic actions of terfenadine. Woosley, R.L., Chen, Y., Freiman, J.P., Gillis, R.A. JAMA (1993) [Pubmed]
  11. Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences. Honig, P.K., Wortham, D.C., Zamani, K., Conner, D.P., Mullin, J.C., Cantilena, L.R. JAMA (1993) [Pubmed]
  12. Histamine increases lung permeability by an H2-receptor mechanism. Braude, S., Royston, D., Coe, C., Barnes, P.J. Lancet (1984) [Pubmed]
  13. Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen. Terrien, M.H., Rahm, F., Fellrath, J.M., Spertini, F. J. Allergy Clin. Immunol. (1999) [Pubmed]
  14. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. Honig, P.K., Woosley, R.L., Zamani, K., Conner, D.P., Cantilena, L.R. Clin. Pharmacol. Ther. (1992) [Pubmed]
  15. Double-blind comparison of terfenadine, chlorpheniramine, and placebo in the treatment of chronic idiopathic urticaria. Grant, J.A., Bernstein, D.I., Buckley, C.E., Chu, T., Fox, R.W., Rocklin, R.E., Schoenwetter, W.F., Spector, S.L., Stafford, C.T., Stroh, J.E. J. Allergy Clin. Immunol. (1988) [Pubmed]
  16. Efficacy of antihistamine pretreatment in the prevention of adverse reactions to Hymenoptera immunotherapy: a prospective, randomized, placebo-controlled trial. Brockow, K., Kiehn, M., Riethmüller, C., Vieluf, D., Berger, J., Ring, J. J. Allergy Clin. Immunol. (1997) [Pubmed]
  17. Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Salata, J.J., Jurkiewicz, N.K., Wallace, A.A., Stupienski, R.F., Guinosso, P.J., Lynch, J.J. Circ. Res. (1995) [Pubmed]
  18. The comparative actions and adverse effect profile of single doses of H1-receptor antihistamines in the airways and skin of subjects with asthma. Wood-Baker, R., Holgate, S.T. J. Allergy Clin. Immunol. (1993) [Pubmed]
  19. Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Benton, R.E., Honig, P.K., Zamani, K., Cantilena, L.R., Woosley, R.L. Clin. Pharmacol. Ther. (1996) [Pubmed]
  20. The effects of an H1-receptor antagonist, terfenadine, on histamine-induced microcirculatory changes and vasopermeability in nasal mucosa. Druce, H.M. J. Allergy Clin. Immunol. (1990) [Pubmed]
  21. Intranasal fluticasone propionate is more effective than terfenadine tablets for seasonal allergic rhinitis. van Bavel, J., Findlay, S.R., Hampel, F.C., Martin, B.G., Ratner, P., Field, E. Arch. Intern. Med. (1994) [Pubmed]
  22. Cetirizine: actions on neurotransmitter receptors. Snowman, A.M., Snyder, S.H. J. Allergy Clin. Immunol. (1990) [Pubmed]
  23. Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. Crumb, W.J., Wible, B., Arnold, D.J., Payne, J.P., Brown, A.M. Mol. Pharmacol. (1995) [Pubmed]
  24. Regulation of potassium channels by nonsedating antihistamines. Berul, C.I., Morad, M. Circulation (1995) [Pubmed]
  25. Efficacy of continuous treatment with astemizole (Hismanal) and terfenadine (Seldane) in ragweed pollen-induced rhinoconjunctivitis. Juniper, E.F., White, J., Dolovich, J. J. Allergy Clin. Immunol. (1988) [Pubmed]
  26. Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly. Simons, K.J., Martin, T.J., Watson, W.T., Simons, F.E. J. Allergy Clin. Immunol. (1990) [Pubmed]
  27. Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone. Mäenpää, J., Hall, S.D., Ring, B.J., Strom, S.C., Wrighton, S.A. Pharmacogenetics (1998) [Pubmed]
  28. Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6. Jones, B.C., Hyland, R., Ackland, M., Tyman, C.A., Smith, D.A. Drug Metab. Dispos. (1998) [Pubmed]
  29. Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338. Furuta, S., Kamada, E., Omata, T., Sugimoto, T., Kawabata, Y., Yonezawa, K., Wu, X.C., Kurimoto, T. Eur. J. Pharmacol. (2004) [Pubmed]
  30. Skin responses to bradykinin, kallidin, and [desArg9]-bradykinin in nonatopic and atopic volunteers. Polosa, R., Djukanovic, R., Rajakulasingam, K., Palermo, F., Holgate, S.T. J. Allergy Clin. Immunol. (1993) [Pubmed]
  31. Safe coadministration of terbinafine and terfenadine: a placebo-controlled crossover study of pharmacokinetic and pharmacodynamic interactions in healthy volunteers. Robbins, B., Chang, C.T., Cramer, J.A., Garreffa, S., Hafkin, B., Hunt, T.L., Meligeni, J. Clin. Pharmacol. Ther. (1996) [Pubmed]
  32. A double-blind evaluation of skin test suppression produced by two doses of terfenadine. Bantz, E.W., Dolen, W.K., Nelson, H.S. J. Allergy Clin. Immunol. (1987) [Pubmed]
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