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Chemical Compound Review

S-Me-TC     (2S)-2-amino-5-[(amino- methylsulfanyl...

Synonyms: CHEMBL106516, CHEBI:275733, CCG-204862, Lopac0_000777, DNC005704, ...
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Disease relevance of S-Methyl-L-thiocitrulline


High impact information on S-Methyl-L-thiocitrulline


Chemical compound and disease context of S-Methyl-L-thiocitrulline


Biological context of S-Methyl-L-thiocitrulline


Associations of S-Methyl-L-thiocitrulline with other chemical compounds


Gene context of S-Methyl-L-thiocitrulline

  • Inhibition of nNOS with 10 micro mol/L S-methyl-L-thiocitrulline significantly decreased the afferent arteriolar diameter of AT1A receptor-deficient mice, from 15.1+/-1.2 to 5.0+/-0.3 micro m (n=7), and the decrease was significantly greater than that observed in wild-type mice (from 15.9+/-1.2 to 10.6+/-1.3 micro m; n=8) [13].
  • For this purpose rat pancreatic islets were cultured for 48 h in medium supplemented without or with 10, 100 or 500 microM of S-methyl-L-thiocitrulline, in the absence or presence of 25 U/ml of interleukin 1 beta (IL-1 beta) [4].
  • The first aim of the present study was to examine nNOS mRNA expression in the renal cortex and to assess the renal functional responses to intrarenal nNOS inhibition by S-methyl-L-thiocitrulline (L-SMTC) in heterozygous TGR and in age-matched transgene-negative Hannover Sprague-Dawley rats (HanSD) [14].

Analytical, diagnostic and therapeutic context of S-Methyl-L-thiocitrulline

  • Perfusion of 10(-3) mol/L S-methyl-L-thiocitrulline (SMTC) with 150 mmol/L NaCl, induces a significant drop in DT [NO], but without a significant increase in collected NO [15].
  • We examined the effects of potent neuronal nitric oxide synthase inhibitors, 3-bromo-7-nitro indazole (3-Br-7-NI) and S-methyl-L-thiocitrulline (S-Me-TC) on general behaviour, vigilance stages and electroencephalographic (EEG) power spectra in rats [9].


  1. S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. Narayanan, K., Spack, L., McMillan, K., Kilbourn, R.G., Hayward, M.A., Masters, B.S., Griffith, O.W. J. Biol. Chem. (1995) [Pubmed]
  2. A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain. Colado, M.I., Camarero, J., Mechan, A.O., Sanchez, V., Esteban, B., Elliott, J.M., Green, A.R. Br. J. Pharmacol. (2001) [Pubmed]
  3. Nitric oxide in obstructive uropathy: role of endothelial nitric oxide synthase. Chang, B., Mathew, R., Palmer, L.S., Valderrama, E., Trachtman, H. J. Urol. (2002) [Pubmed]
  4. S-methyl-L-thiocitrulline counteracts interleukin 1 beta induced suppression of pancreatic islet function in vitro, but does not protect against multiple low-dose streptozotocin-induced diabetes in vivo. Sternesjö, J., Welsh, N., Sandler, S. Cytokine (1997) [Pubmed]
  5. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Steppan, J., Ryoo, S., Schuleri, K.H., Gregg, C., Hasan, R.K., White, A.R., Bugaj, L.J., Khan, M., Santhanam, L., Nyhan, D., Shoukas, A.A., Hare, J.M., Berkowitz, D.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Neuronal nitric oxide reduces sympathetic excitability by modulation of central glutamate effects in pigs. Zanzinger, J., Czachurski, J., Seller, H. Circ. Res. (1997) [Pubmed]
  7. Brain neuronal nitric oxide synthase neuron-mediated sympathoinhibition is enhanced in hypertensive Dahl rats. Tandai-Hiruma, M., Horiuchi, J., Sakamoto, H., Kemuriyama, T., Hirakawa, H., Nishida, Y. J. Hypertens. (2005) [Pubmed]
  8. Characterization of the effects of two new arginine/citrulline analogues on constitutive and inducible nitric oxide synthases in rat aorta. Joly, G.A., Narayanan, K., Griffith, O.W., Kilbourn, R.G. Br. J. Pharmacol. (1995) [Pubmed]
  9. Vigilance and EEG power in rats: effects of potent inhibitors of the neuronal nitric oxide synthase. Dzoljic, E., van Leeuwen, R., de Vries, R., Dzoljic, M.R. Naunyn Schmiedebergs Arch. Pharmacol. (1997) [Pubmed]
  10. nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice. Itzhak, Y., Martin, J.L., Ail, S.F. Neuroreport (2000) [Pubmed]
  11. Inhibition of nitric oxide synthase causes elevation of hearing thresholds. Zdanski, C.J., Carrasco, V., Johnson, K., Prazma, J., Pillsbury, H.C. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1998) [Pubmed]
  12. Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy. Vaupel, D.B., Kimes, A.S., London, E.D. Eur. J. Pharmacol. (1997) [Pubmed]
  13. Blunted tubuloglomerular feedback by absence of angiotensin type 1A receptor involves neuronal NOS. Ichihara, A., Hayashi, M., Koura, Y., Tada, Y., Sugaya, T., Hirota, N., Saruta, T. Hypertension (2002) [Pubmed]
  14. Role of nNOS in regulation of renal function in hypertensive Ren-2 transgenic rats. Cervenka, L., Kramer, H.J., Malý, J., Vanecková, I., Bäcker, A., Bokemeyer, D., Bader, M., Ganten, D., Mitchell, K.D. Physiological research / Academia Scientiarum Bohemoslovaca. (2002) [Pubmed]
  15. Short-term modulation of distal tubule fluid nitric oxide in vivo by loop NaCl reabsorption. Levine, D.Z., Burns, K.D., Jaffey, J., Iacovitti, M. Kidney Int. (2004) [Pubmed]
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