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Chemical Compound Review

Tocris-0800     7-nitroindazole

Synonyms: AC1N81P7, NCGC00024798-01, 7-nitroindazol-2-ide
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Disease relevance of NSC 72843


Psychiatry related information on NSC 72843


High impact information on NSC 72843

  • 45Ca uptake by cardiac SR vesicles, catalyzed by Ca2+-ATPase, was inhibited by NO. produced endogenously from cardiac SR NOS, and 7-nitroindazole, a selective nNOS inhibitor, completely prevented this inhibition [7].
  • Cell death after oxygen and glucose deprivation was ameliorated in male cultures, but not female cultures, by the addition of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor [8].
  • When spatial learning was inhibited by treatment with 7-nitroindazole, an inhibitor of brain nitric oxide synthase, the increase in the hippocampal BDNF mRNA did not occur [9].
  • In contrast, neuronal NOS (NOS1)-deficient mice and wild-type mice treated with the nonspecific NOS inhibitor NG-nitro-L-arginine methyl ester and the NOS1-specific inhibitor 7-nitroindazole all had delayed parasite clearance [10].
  • Cerebral blood flow response as well as BOLD signal intensity changes following electrical stimulation were abolished within 10 min after application of 7 nitroindazole, whereas somatosensory-evoked potentials were only slightly affected but still clearly detectable [11].

Chemical compound and disease context of NSC 72843


Biological context of NSC 72843


Anatomical context of NSC 72843


Associations of NSC 72843 with other chemical compounds

  • We examined the effects of N omega-nitro-L-arginine methyl ester (L-NAME), a general inhibitor of nitric oxide synthase (NOS), and 7-nitroindazole (7-NI), a selective inhibitor of neuronal NOS, on aprikalim-induced cerebral vasodilation [24].
  • Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity [25].
  • After administration of the vehicle for 7-nitroindazole (peanut oil), L-arginine (100 micromol/kg per min for 10 min) decreased both resting and baroreceptor-unloaded RSNA, whereas after pretreatment with 7-nitroindazole, the L-arginine-induced suppression was reversed, in Dahl salt-sensitive rats receiving a high-salt diet [26].
  • Alone, NOS inhibitors and promoters do not affect prepulse inhibition; however, when tested in combination with PCP, the NOS inhibitors, L-NOARG, 7-nitroindazole and arcaine--but not the NR2B-selective polyamine site NMDA antagonist, eliprodil--attenuated PCP-induced disruption of prepulse inhibition of the acoustic startle response [27].
  • The selective neuronal NOS inhibitor, 7-nitroindazole (7-NI; 100 micromol/l) increased EFS-induced contraction only in segments from ouabain-treated rats [28].

Gene context of NSC 72843


Analytical, diagnostic and therapeutic context of NSC 72843


  1. Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation. Evidence for an endothelium-independent mechanism. Kajekar, R., Moore, P.K., Brain, S.D. Circ. Res. (1995) [Pubmed]
  2. Nitric oxide in traumatic brain injury. Cherian, L., Hlatky, R., Robertson, C.S. Brain Pathol. (2004) [Pubmed]
  3. Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. Donovan, M., Carmody, R.J., Cotter, T.G. J. Biol. Chem. (2001) [Pubmed]
  4. The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats. Nanri, K., Montécot, C., Springhetti, V., Seylaz, J., Pinard, E. Stroke (1998) [Pubmed]
  5. 7-Nitroindazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis. Paul, R., Koedel, U., Pfister, H.W. J. Cereb. Blood Flow Metab. (1997) [Pubmed]
  6. Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia. Richter, A., Löschmann, P.A., Löscher, W. Br. J. Pharmacol. (2000) [Pubmed]
  7. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Xu, K.Y., Huso, D.L., Dawson, T.M., Bredt, D.S., Becker, L.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Sex differences in cell death. Li, H., Pin, S., Zeng, Z., Wang, M.M., Andreasson, K.A., McCullough, L.D. Ann. Neurol. (2005) [Pubmed]
  9. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. Mizuno, M., Yamada, K., Olariu, A., Nawa, H., Nabeshima, T. J. Neurosci. (2000) [Pubmed]
  10. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. Li, E., Zhou, P., Singer, S.M. J. Immunol. (2006) [Pubmed]
  11. BOLD response during uncoupling of neuronal activity and CBF. Burke, M., Bührle, C.h. Neuroimage (2006) [Pubmed]
  12. Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus. Hashiguchi, A., Yano, S., Morioka, M., Hamada, J., Ushio, Y., Takeuchi, Y., Fukunaga, K. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  13. The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats. Sekiguchi, F., Mita, Y., Kamanaka, Y., Kawao, N., Matsuya, H., Taga, C., Kawabata, A. Neurosci. Lett. (2004) [Pubmed]
  14. Role of nitric oxide on motor behavior. Del Bel, E.A., Guimarães, F.S., Bermúdez-Echeverry, M., Gomes, M.Z., Schiaveto-de-souza, A., Padovan-Neto, F.E., Tumas, V., Barion-Cavalcanti, A.P., Lazzarini, M., Nucci-da-Silva, L.P., de Paula-Souza, D. Cell. Mol. Neurobiol. (2005) [Pubmed]
  15. Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retina. Sakamoto, K., Yonoki, Y., Kubota, Y., Kuwagata, M., Saito, M., Nakahara, T., Ishii, K. Exp. Eye Res. (2006) [Pubmed]
  16. NMDA-mediated toxicity to striatal neurons is not reversed by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase. Löschmann, P.A., Eblen, F., Wüllner, U., Klockgether, T. J. Neural Transm. Suppl. (1995) [Pubmed]
  17. Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal nitric oxide synthase. Stefanovic, B., Schwindt, W., Hoehn, M., Silva, A.C. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  18. 7-Nitroindazole impedes erythrocyte flow response to isovolemic hemodilution in the cerebral capillary circulation. Hudetz, A.G., Wood, J.D., Kampine, J.P. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  19. Nitric oxide synthase inhibitors. Preclinical studies of potential use for treatment of opioid withdrawal. Vaupel, D.B., Kimes, A.S., London, E.D. Neuropsychopharmacology (1995) [Pubmed]
  20. Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation. Zhu, X.J., Hua, Y., Jiang, J., Zhou, Q.G., Luo, C.X., Han, X., Lu, Y.M., Zhu, D.Y. Neuroscience (2006) [Pubmed]
  21. The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. Yoshida, T., Limmroth, V., Irikura, K., Moskowitz, M.A. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  22. MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice. Matthews, R.T., Beal, M.F., Fallon, J., Fedorchak, K., Huang, P.L., Fishman, M.C., Hyman, B.T. Neurobiol. Dis. (1997) [Pubmed]
  23. Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures. Montécot, C., Rondi-Reig, L., Springhetti, V., Seylaz, J., Pinard, E. Neuroscience (1998) [Pubmed]
  24. Interaction between ATP-sensitive K+ channels and nitric oxide on pial arterioles in piglets. Bari, F., Errico, R.A., Louis, T.M., Busija, D.W. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  25. Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity. Di Monte, D.A., Royland, J.E., Anderson, A., Castagnoli, K., Castagnoli, N., Langston, J.W. J. Neurochem. (1997) [Pubmed]
  26. Neuronal nitric oxide strongly suppresses sympathetic outflow in high-salt Dahl rats. Nishida, Y., Chen, Q.H., Tandai-Hiruma, M., Terada, S., Horiuchi, J. J. Hypertens. (2001) [Pubmed]
  27. Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition. Wiley, J.L. Neuropsychopharmacology (1998) [Pubmed]
  28. Neurogenic nitric oxide release increases in mesenteric arteries from ouabain hypertensive rats. Xavier, F.E., Salaices, M., Márquez-Rodas, I., Alonso, M.J., Rossoni, L.V., Vassallo, D.V., Balfagón, G. J. Hypertens. (2004) [Pubmed]
  29. Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis. Xu, L., Carter, E.P., Ohara, M., Martin, P.Y., Rogachev, B., Morris, K., Cadnapaphornchai, M., Knotek, M., Schrier, R.W. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  30. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Southan, G.J., Szabó, C. Biochem. Pharmacol. (1996) [Pubmed]
  31. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Tao, F., Tao, Y.X., Mao, P., Zhao, C., Li, D., Liaw, W.J., Raja, S.N., Johns, R.A. Neuroscience (2003) [Pubmed]
  32. Nitric oxide enhances substance P-induced itch-associated responses in mice. Andoh, T., Kuraishi, Y. Br. J. Pharmacol. (2003) [Pubmed]
  33. Possible involvement of neuronal nitric oxide synthase enzyme in early-phase isoflurane-induced hypotension in rats. Ellenberger, E.A., Lucas, H.L., Mueller, J.L., Barrington, P.L., Chung, E., Ohgami, Y., Quock, R.M. Life Sci. (2004) [Pubmed]
  34. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Gürsoy-Ozdemir, Y., Bolay, H., Saribaş, O., Dalkara, T. Stroke (2000) [Pubmed]
  35. Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain. Chu, Y.C., Guan, Y., Skinner, J., Raja, S.N., Johns, R.A., Tao, Y.X. Pain (2005) [Pubmed]
  36. Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. Cheng, B.C., Chang, C.P., Lin, M.T., Lee, C.C. Neuropharmacology (2007) [Pubmed]
  37. Anxiolytic-like effects induced by nitric oxide synthase inhibitors microinjected into the medial amygdala of rats. Forestiero, D., Manfrim, C.M., Guimarães, F.S., de Oliveira, R.M. Psychopharmacology (Berl.) (2006) [Pubmed]
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