Disease relevance of STROPHANTHIN

• The effect of carbocromene on strophanthin-induced ventricular tachycardia in dogs [1].
• Glibenclamide decrease, arrhythmogenesis during acute myocardial infarction in rats and reduces strophanthin cardiotoxicity in rabbits [2].
• Alterations of substances (DNA, myoglobin, myosin, protein) in experimentally induced cardiac hypertrophy and under the influence of drugs (isoproterenol, cytostatics, strophanthin) [3].
• Retinal toxicity in albino rabbits induced by intravitreal injection of strophanthin-K [4].
• Experiments on rats and rabbits using models of arrhythmias induced by vasopressin, epinephrine, strophanthin, and CaCl2 showed that antioxidants derived from 1,4-dihydropyridines, dibunol, and alpha-tocopherol possessed antiarrhythmic effects [5].

High impact information on STROPHANTHIN

• The effect of practolol, propranolol and strophanthin compared with placebo on exercise tolerance and a postural test in patients with hypertrophic cardiomyopathy [6].
• Elimination half-lives of strophanthin and digoxin are prolonged, whereas the elimination half-life of digitoxin is unchanged [7].
• Similarly, low or near clinical doses of diatrizoate given with doses of Strophanthin-K in the lethal range produced mortalities significantly greater than for the Strophanthin-K alone [8].
• The prolongation of the action potential at rest was suppressed with aminazine and strophanthin [9].
• Effect of strophanthin G on peroxidase oxidation kinetics of slowly oxidizable peroxidase substrates [10].

Chemical compound and disease context of STROPHANTHIN

• It is concluded that the combined use of imipramine and adriamycin or strophanthin did not lead to a serious enhancement of the toxicity of the tricyclic antidepressant [11].

Anatomical context of STROPHANTHIN

• Ashwagandha treatment increased the duration of contractility in functional test for the resistance of frog heart muscle towards the toxic action of strophanthin-K [12].
• 1. The efflux of 22Na from single barnacle muscle fibers poisoned with ouabain (strophanthin G) is found to be very sensitive to the tumor-promoting agent, phorbol dibutyrate (PDBu) [13].
• (3) Preincubation of mast cells in a calcium-free medium with the glycosides (10(-4) mol/l) has a dual-effect on histamine secretion induced by compound 48/80: water soluble glycosides (strophanthin G and K) potentiate histamine release, whereas the liposoluble glycosides (digitoxin, digitoxigenine) decrease the secretory response [14].

Associations of STROPHANTHIN with other chemical compounds

• 5. At acidic pH, strophanthin G activated peroxidase during the oxidation of thioproperazine by the uncompetitive mechanism, and when triftazine was oxidized, the inhibition was noncompetitive [10].
• Barbiturate-induced failure can be fully reversed by the intravenous injection of CaCl2, isoproterenol, or strophanthin [15].
• Steady-state kinetics of thioproperazine, triftazine, aminazine, and o-dianisidine oxidation with hydrogen peroxide catalyzed by horseradish peroxidase were studied in the presence of strophanthin G [10].

Analytical, diagnostic and therapeutic context of STROPHANTHIN

• In the group of rats treated with EPL, reactivity to strophanthin was about the same as in the control group [16].
• Chronic treatment with increasing doses of strophanthin induced significant flattening of the T wave in rats with and without imipramine therapy, but did not influence the changes of the ECG or body weight gain caused by imipramine [11].

References