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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Bundle of His

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Disease relevance of Bundle of His


High impact information on Bundle of His

  • Using His bundle recording techniques, we examined direct and autonomically mediated conduction system effects of quinidine in five cardiac transplant recipients who have anatomically denervated hearts [6].
  • By recording atrial, His, and ventricular signals with intracardiac electrodes, we show that this decrease is attributed to significantly accelerated conduction above the His bundle (atrial-His interval: 27.9 +/- 5.1 ms in Cx30.2(LacZ/LacZ) versus 37.1 +/- 4.1 ms in Cx30.2(+/+) mice), whereas HV conduction is unaltered [7].
  • HNK-1 stains the developing atrioventricular conduction system, ie, the bundle branches, His bundle, right atrioventricular ring, and retroaortic ring [8].
  • The diastolic slopes were recorded through a unipolar lead consisting of a terminal of an electrode catheter placed in the His bundle area paired with an indifferent terminal on the superior vena cava [9].
  • Electrophysiologic studies using the His bundle electrogram (HBE) and histologic studies of serial sections of the conduction system were correlated in two groups of deceased patients [10].

Chemical compound and disease context of Bundle of His


Biological context of Bundle of His


Anatomical context of Bundle of His


Associations of Bundle of His with chemical compounds

  • The H-V interval during sinus rhythm and the S1 V1 interval during His bundle pacing at all CLs did not change after ouabain [23].
  • A repeat electrophysiologic study 4 days after digoxin was discontinued revealed complete trifascicular block (distal to H) with intact conduction between the atrium and the His bundle (AH of 150 msec) [24].
  • Both adenosine and ATP depressed AV conduction by lengthening the atrial to His bundle (AH) interval [25].
  • During retrograde refractory period studies, the longest V1V2 interval at which a retrograde His bundle potential (H2) emerged from the V2 electrogram (relative refractory period of the His-Purkinje system) was consistently longer after amiodarone as compared with the control period (376.4 +/- 46.6 versus 318.8 +/- 33.1 ms, p less than 0.005) [26].
  • In guinea pig isolated hearts, m-DITC-ADAC (5 microM) prolonged the stimulus to His bundle (SH) interval by 2.1-fold; this response could be prevented by the antagonist 8-cyclopentyltheophylline (5 microM) [27].

Gene context of Bundle of His

  • We find that Tbx5 is expressed throughout the central conduction system, including the atrioventricular bundle and bundle branch conduction system [28].
  • For example, Cx40 deficiency results in sinoatrial conduction impairments, a significant decrease of the conduction velocity in the atria, and a delay of the propagation of impulse in the His bundle [29].
  • It is concluded that the AVN derives from the atrioventricular canal myocardium, the bundle of His from the ventricular myocardium, and the bundle branches from the ventricular trabeculations [30].
  • Cx43 is not detected either in the His bundle or in the proximal parts of the bundle branches, and consequently, Cx40 is the first connexin demonstrated in this region of the rat conduction system [20].
  • However, the ventricular part of the conduction system, comprising atrioventricular bundle and bundle branches, are almost devoid of SERCA2 mRNA [31].

Analytical, diagnostic and therapeutic context of Bundle of His


  1. Familial atrioventricular heart block; an autosomal dominant trait. Waxman, M.B., Catching, J.D., Felderhof, C.H., Downar, E., Silver, M.D., Abbott, M.M. Circulation (1975) [Pubmed]
  2. Abolition and modification of reentry within the His-Purkinje system by procainamide in man. Reddy, C.P., Lynch, M. Circulation (1978) [Pubmed]
  3. Lidocaine and His bundle extrasystoles. His bundle discharge conducted with functional right of left bundle-branch block, or blocked entirely (concealed). Bonner, A.J., Zipes, D.P. Arch. Intern. Med. (1976) [Pubmed]
  4. Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenègre disease. Probst, V., Kyndt, F., Potet, F., Trochu, J.N., Mialet, G., Demolombe, S., Schott, J.J., Baró, I., Escande, D., Le Marec, H. J. Am. Coll. Cardiol. (2003) [Pubmed]
  5. Autoradiographic localization and quantitation of beta 1- and beta 2-adrenoceptors in the human atrioventricular conducting system: a comparison of patients with idiopathic dilated cardiomyopathy and ischemic heart disease. Elnatan, J., Molenaar, P., Rosenfeldt, F.L., Summers, R.J. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  6. The electrophysiologic effects of quinidine in the transplanted human heart. Mason, J.W., Winkle, R.A., Rider, A.K., Stinson, E.B., Harrison, D.C. J. Clin. Invest. (1977) [Pubmed]
  7. Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node. Kreuzberg, M.M., Schrickel, J.W., Ghanem, A., Kim, J.S., Degen, J., Janssen-Bienhold, U., Lewalter, T., Tiemann, K., Willecke, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Development of the cardiac conduction tissue in human embryos using HNK-1 antigen expression: possible relevance for understanding of abnormal atrial automaticity. Blom, N.A., Gittenberger-de Groot, A.C., DeRuiter, M.C., Poelmann, R.E., Mentink, M.M., Ottenkamp, J. Circulation (1999) [Pubmed]
  9. Recording of diastolic slope with catheters during junctional rhythm in humans. Hariman, R.J., Gomes, J.A., El-Sherif, N. Circulation (1984) [Pubmed]
  10. Electrophysiologic and histologic correlations in chronic complete atrioventricular block. Ohkawa, S., Sugiura, M., Itoh, Y., Kitano, K., Hiraoka, K., Ueda, K., Murakami, M. Circulation (1981) [Pubmed]
  11. Evaluation of N-0861, (+-)-N6-endonorbornan-2-yl-9-methyladenine, as an A1 subtype-selective adenosine receptor antagonist in the guinea pig isolated heart. Shryock, J.C., Travagli, H.C., Belardinelli, L. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  12. Selective potentiation by an A1 adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart. Amoah-Apraku, B., Xu, J., Lu, J.Y., Pelleg, A., Bruns, R.F., Belardinelli, L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  13. Fast and slow idioventricular rhythms in the canine heart: a study of their mechanism using antiarrhythmic drugs and electrophysiologic testing. Ilvento, J.P., Provet, J., Danilo, P., Rosen, M.R. Am. J. Cardiol. (1982) [Pubmed]
  14. Electrophysiologic effects of an acute beta-blockade induced by bisoprolol in patients with supraventricular tachycardia as assessed by His-bundle electrograms. Neuss, H., Conrad, A., Mitrovic, V., Schlepper, M. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
  15. Timing and magnitude of serum creatine kinase-MB after transcatheter cardiac tissue fulguration in man. Lesser, J., Goldenberg, I.F., Milstein, S., Dunnigan, A., Dunbar, D., Gornick, C.C., Reyes, W., Benditt, D.G. International journal of cardiology. (1990) [Pubmed]
  16. Electrophysiological effects of high-dose propranolol in dogs: evidence in vivo for effects not mediated by the beta adrenoceptor. Dawson, A.K., Reele, S.B., Wood, A.J., Duff, H.J., Woosley, R.L., Smith, R.F. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  17. Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction. Alcoléa, S., Jarry-Guichard, T., de Bakker, J., Gonzàlez, D., Lamers, W., Coppen, S., Barrio, L., Jongsma, H., Gros, D., van Rijen, H. Circ. Res. (2004) [Pubmed]
  18. Histopathology of the conduction system in the sudden infant death syndrome. Lie, J.T., Rosenberg, H.S., Erickson, E.E. Circulation (1976) [Pubmed]
  19. Baroreceptor control of atrioventricular conduction in man. Mancia, G., Bonazzi, O., Pozzoni, L., Ferrari, A., Gardumi, M., Gregorini, L., Perondi, R. Circ. Res. (1979) [Pubmed]
  20. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Gros, D., Jarry-Guichard, T., Ten Velde, I., de Maziere, A., van Kempen, M.J., Davoust, J., Briand, J.P., Moorman, A.F., Jongsma, H.J. Circ. Res. (1994) [Pubmed]
  21. Laser catheter-induced atrioventricular nodal delays and atrioventricular block in dogs: acute and chronic observations. Narula, O.S., Boveja, B.K., Cohen, D.M., Narula, J.T., Tarjan, P.P. J. Am. Coll. Cardiol. (1985) [Pubmed]
  22. Iopamidol: a new contrast medium in coronary angiography. Comparison, on electrophysiological changes in man, with a commonly used contrast medium. Niccoli, L., Bellandi, M., Benedini, G., Cuccia, C., Petroboni, V., Visioli, O. Eur. Heart J. (1983) [Pubmed]
  23. The effect of digitalis on refractoriness of the intact canine His-Purkinje system. Gomes, J.A., Damato, A.N., Bobb, G.A., Lau, S.H. Circulation (1978) [Pubmed]
  24. Concealed nonparoxysmal junctional tachycardia. Wyndham, C.R., Dhingra, R.C., Smith, T., Best, D., Rosen, K.M. Circulation (1979) [Pubmed]
  25. Effect of adenosine and adenosine-5'-triphosphate on atrioventricular conduction in patients. Favale, S., Di Biase, M., Rizzo, U., Belardinelli, L., Rizzon, P. J. Am. Coll. Cardiol. (1985) [Pubmed]
  26. Effect of amiodarone on conduction and refractoriness of the His-Purkinje system in the human heart. Shenasa, M., Denker, S., Mahmud, R., Lehmann, M., Estrada, A., Akhtar, M. J. Am. Coll. Cardiol. (1984) [Pubmed]
  27. Persistent activation by and receptor reserve for an irreversible A1-adenosine receptor agonist in DDT1 MF-2 cells and in guinea pig heart. Zhang, J., Belardinelli, L., Jacobson, K.A., Otero, D.H., Baker, S.P. Mol. Pharmacol. (1997) [Pubmed]
  28. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Moskowitz, I.P., Pizard, A., Patel, V.V., Bruneau, B.G., Kim, J.B., Kupershmidt, S., Roden, D., Berul, C.I., Seidman, C.E., Seidman, J.G. Development (2004) [Pubmed]
  29. Gap junctional connexins in the developing mouse cardiac conduction system. Miquerol, L., Dupays, L., Théveniau-Ruissy, M., Alcoléa, S., Jarry-Guichard, T., Abran, P., Gros, D. Novartis Found. Symp. (2003) [Pubmed]
  30. Molecular characterization of the ventricular conduction system in the developing mouse heart: topographical correlation in normal and congenitally malformed hearts. Franco, D., Icardo, J.M. Cardiovasc. Res. (2001) [Pubmed]
  31. Patterns of expression of sarcoplasmic reticulum Ca(2+)-ATPase and phospholamban mRNAs during rat heart development. Moorman, A.F., Vermeulen, J.L., Koban, M.U., Schwartz, K., Lamers, W.H., Boheler, K.R. Circ. Res. (1995) [Pubmed]
  32. Noninvasive recording of His-Purkinje activity in patients with complete atrioventricular block. Clinical application of an "automated discrimination circuit". Takeda, H., Kitamura, K., Takanashi, T., Tokuoka, T., Hamamoto, H., Katoh, T., Niki, I., Hishimoto, Y. Circulation (1979) [Pubmed]
  33. Simultaneous anterograde fast-slow atrioventricular nodal pathway conduction after procainamide. Gomes, J.A., Kang, P.S., Kelen, G., Khan, R., El-Sherif, N. Am. J. Cardiol. (1980) [Pubmed]
  34. Correlates of prolonged HV conduction in aortic stenosis. MacMillan, R.M., Demorizi, N.M., Gessman, L.J., Maranhao, V. Am. Heart J. (1985) [Pubmed]
  35. Effects of autonomic blockade on the inotropic and electrophysiologic response to digitoxin in the intact dog. Amlie, J.P., Storstein, L. J. Cardiovasc. Pharmacol. (1980) [Pubmed]
  36. Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts. Stark, G., Stark, U., Windisch, M., Vicenzi, M., Eggenreich, U., Nagl, S., Kral, K., Pilger, E., Tritthart, H.A. Basic Res. Cardiol. (1991) [Pubmed]
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