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Ltb4r  -  leukotriene B4 receptor

Rattus norvegicus

Synonyms: Blt, LTB4-R 1, LTB4-R1, Leukotriene B4 receptor 1
 
 
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Disease relevance of Ltb4r

 

High impact information on Ltb4r

 

Chemical compound and disease context of Ltb4r

 

Biological context of Ltb4r

 

Anatomical context of Ltb4r

 

Associations of Ltb4r with chemical compounds

  • In rats pretreated with the LTB4 receptor antagonist, U-75302, GFR and RBF remained depressed to levels no different than in animals which received NTS alone [13].
  • Effect of the leukotriene B4 receptor antagonist SC-41930 on colonic inflammation in rat, guinea pig and rabbit [4].
  • Synergistic effects of pranlukast and leukotriene B4 receptor antagonist on antigen-induced pulmonary reaction [14].
  • Pharmacological activity of the second generation leukotriene B4 receptor antagonist, SC-53228: effects on acute colonic inflammation and hepatic function in rodents [15].
  • The effect of a potent and selective LTB4 receptor antagonist, LY29311INa (2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]-propoxy]-phenoxy]benzoic acid sodium salt) was compared with those of indomethacin and dexamethasone [16].
 

Analytical, diagnostic and therapeutic context of Ltb4r

References

  1. The leukotriene B4 receptor antagonist ONO-4057 inhibits nephrotoxic serum nephritis in WKY rats. Suzuki, S., Kuroda, T., Kazama, J.I., Imai, N., Kimura, H., Arakawa, M., Gejyo, F. J. Am. Soc. Nephrol. (1999) [Pubmed]
  2. Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia. Barone, F.C., Schmidt, D.B., Hillegass, L.M., Price, W.J., White, R.F., Feuerstein, G.Z., Clark, R.K., Lee, E.V., Griswold, D.E., Sarau, H.M. Stroke (1992) [Pubmed]
  3. Effect of acute systemic hypoxia on vascular permeability and leucocyte adherence in the anaesthetised rat. Mian, R., Marshall, J.M. Cardiovasc. Res. (1993) [Pubmed]
  4. Effect of the leukotriene B4 receptor antagonist SC-41930 on colonic inflammation in rat, guinea pig and rabbit. Fretland, D.J., Widomski, D., Tsai, B.S., Zemaitis, J.M., Levin, S., Djuric, S.W., Shone, R.L., Gaginella, T.S. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  5. Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Arndt, H., Russell, J.B., Kurose, I., Kubes, P., Granger, D.N. Gastroenterology (1993) [Pubmed]
  6. Leukotriene B4 induces formation of inositol phosphates in rat peritoneal polymorphonuclear leukocytes. Mong, S., Chi-Rosso, G., Miller, J., Hoffman, K., Razgaitis, K.A., Bender, P., Crooke, S.T. Mol. Pharmacol. (1986) [Pubmed]
  7. LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists. Pellas, T.C., Colombo, C., Fryer, L.R., Pastor, G., Haston, W., Raychaudhuri, A., Kotyuk, B., Greenspan, P.D., Healy, C., DiPasquale, G. Journal of pharmacological and toxicological methods. (1993) [Pubmed]
  8. Granulocyte infiltration in experimental colitis in the rat is interleukin-1 dependent and leukotriene independent. McCafferty, D.M., Rioux, K.J., Wallace, J.L. Eicosanoids (1992) [Pubmed]
  9. The pharmacokinetics and metabolism of SC-53228, a specific leukotriene B4 receptor antagonist. Paulson, S., Readus, Y., Bulik, S., Schoenhard, G., Stolzenbach, J., Fretland, D. Inflamm. Res. (1995) [Pubmed]
  10. Analogs of leukotriene B4: effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors. Leblanc, Y., Fitzsimmons, B.J., Charleson, S., Alexander, P., Evans, J.F., Rokach, J. Prostaglandins (1987) [Pubmed]
  11. Ischemia/reperfusion-induced microvascular dysfunction: role of oxidants and lipid mediators. Kurose, I., Argenbright, L.W., Wolf, R., Lianxi, L., Granger, D.N. Am. J. Physiol. (1997) [Pubmed]
  12. Roles of thromboxane A2 and leukotriene B4 in radicular pain induced by herniated nucleus pulposus. Kawakami, M., Matsumoto, T., Tamaki, T. J. Orthop. Res. (2001) [Pubmed]
  13. Hemodynamic role of arachidonate 12- and 5-lipoxygenases in nephrotoxic serum nephritis. Wu, S.H., Bresnahan, B.A., Lianos, E.A. Kidney Int. (1993) [Pubmed]
  14. Synergistic effects of pranlukast and leukotriene B4 receptor antagonist on antigen-induced pulmonary reaction. Sakurada, T., Abe, M., Kodani, M., Sakata, N., Katsuragi, T. Eur. J. Pharmacol. (1999) [Pubmed]
  15. Pharmacological activity of the second generation leukotriene B4 receptor antagonist, SC-53228: effects on acute colonic inflammation and hepatic function in rodents. Fretland, D.J., Anglin, C.P., Widomski, D., Baron, D.A., Maziasz, T., Smith, P.F. Inflammation (1995) [Pubmed]
  16. Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na. Kuwabara, K., Jyoyama, H., Fleisch, J.H., Hori, Y. Inflamm. Res. (2002) [Pubmed]
 
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