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Chemical Compound Review

Ergocalm     10-chloro-2-(2-chlorophenyl)- 4-hydroxy-6...

Synonyms: Noctamid, Loramet, Loretam, Noctamide, Lormetazepam, ...
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Disease relevance of Loramet


Psychiatry related information on Loramet


High impact information on Loramet


Chemical compound and disease context of Loramet


Biological context of Loramet


Associations of Loramet with other chemical compounds


Gene context of Loramet

  • Evidence of a significant residual sedative effect was found on CFF and ARS ratings only after acute dosing with lormetazepam 2 mg [27].
  • Lormetazepam 1 mg shows no residual sedative effect as measured by CFF and ARS, the morning following either acute or repeated doses [27].

Analytical, diagnostic and therapeutic context of Loramet


  1. Effects of uremia and hemodialysis on lormetazepam disposition. Kampf, D., Huempel, M., Lerche, U., Kessel, M. Clin. Pharmacol. Ther. (1981) [Pubmed]
  2. Can a rapidly-eliminated hypnotic cause daytime anxiety? Adam, K., Oswald, I. Pharmacopsychiatry (1989) [Pubmed]
  3. Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers. Hildebrand, M., Hellstern, A., Hümpel, M., Hellenbrecht, D., Saller, R. European journal of drug metabolism and pharmacokinetics. (1990) [Pubmed]
  4. Efficacy of lorazepam and lormetazepam as intravenous premedicants for anesthesia and surgery. Claeys, M.A., Camu, F. Acta anaesthesiologica Belgica. (1986) [Pubmed]
  5. Fixed drug eruption with lormetazepam (Noctamid). Jafferany, M., Haroon, T.S. Dermatologica (1988) [Pubmed]
  6. Antagonizing the effects of experimentally induced sleep disturbance in healthy volunteers by lormetazepam and zolpidem. Cluydts, R., De Roeck, J., Cosyns, P., Lacante, P. Journal of clinical psychopharmacology. (1995) [Pubmed]
  7. Effects of repeated dose nitrazepam and lormetazepam on psychomotor performance in the elderly. Morgan, K. Psychopharmacology (Berl.) (1985) [Pubmed]
  8. Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788. Dorow, R., Berenberg, D., Duka, T., Sauerbrey, N. Psychopharmacology (Berl.) (1987) [Pubmed]
  9. Dose-response studies of lormetazepam: efficacy, side effects, and rebound insomnia. Kales, A., Bixler, E.O., Soldatos, C.R., Mitsky, D.J., Kales, J.D. Journal of clinical pharmacology. (1982) [Pubmed]
  10. Kinetics and biotransformation of lormetazepam. II. Radioimmunologic determinations in plasma and urine of young and elderly subjects: first-pass effect. Hümpel, M., Nieuweboer, B., Milius, W., Hanke, H., Wendt, H. Clin. Pharmacol. Ther. (1980) [Pubmed]
  11. Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. Riemann, D., Voderholzer, U., Cohrs, S., Rodenbeck, A., Hajak, G., Rüther, E., Wiegand, M.H., Laakmann, G., Baghai, T., Fischer, W., Hoffmann, M., Hohagen, F., Mayer, G., Berger, M. Pharmacopsychiatry (2002) [Pubmed]
  12. Intravenous flumazenil following prolonged exposure to lormetazepam in humans: lack of precipitated withdrawal. Gerra, G., Giucasto, G., Zaimovic, A., Fertonani, G., Chittolini, B., Avanzini, P., Caccavari, R., Delsignore, R. International clinical psychopharmacology. (1996) [Pubmed]
  13. Controlled comparison of a new sublingual lormetazepam formulation and i.v. diazepam in outpatient minor oral surgery. O'Boyle, C.A., Barry, H., Fox, E., McCreary, C., Bewley, A. British journal of anaesthesia. (1988) [Pubmed]
  14. Anterograde and retrograde amnesia after lormetazepam and flunitrazepam. Ott, H., Rohloff, A., Aufdembrinke, B., Fichte, K. Psychopharmacology series. (1988) [Pubmed]
  15. Amnesic effects of lormetazepam. Roehrs, T., McLenaghan, A., Koshorek, G., Zorick, F., Roth, T. Psychopharmacology. Supplementum. (1984) [Pubmed]
  16. The influence of chlormethiazole in comparison to thioridazine on body temperature and postural hypotension in healthy adults and healthy elderly volunteers. McCarthy, S.T., John, S.M., McCarthy, G.L., Wollner, L. Acta psychiatrica Scandinavica. Supplementum. (1986) [Pubmed]
  17. Double-blind evaluation of the safety and hypnotic efficacy of lormetazepam in general practice. Moja, E.A., Scamonatti, L., Maxia, D., Camera, A., Gherardi, S. Clinical therapeutics. (1983) [Pubmed]
  18. Pharmacodynamic correlates of modified absorption: studies with lormetazepam. Pierce, D.M., Franklin, R.A., Harry, T.V., Nicholson, A.N. British journal of clinical pharmacology. (1984) [Pubmed]
  19. Alcohol interaction of lormetazepam, mepindolol sulphate and diazepam measured by performance on the driving simulator. Willumeit, H.P., Ott, H., Neubert, W., Hemmerling, K.G., Schratzer, M., Fichte, K. Pharmacopsychiatry (1984) [Pubmed]
  20. Minimal biliary excretion and enterohepatic recirculation of lormetazepam in man as investigated by a new nasobiliary drainage technique. Hellstern, A., Hildebrand, M., Hümpel, M., Hellenbrecht, D., Saller, R., Madetzki, C. International journal of clinical pharmacology, therapy, and toxicology. (1990) [Pubmed]
  21. Lormetazepam, memory and information processing: a review. Bhatti, J.Z., Alford, C.A., Hindmarch, I. Psychopharmacology series. (1988) [Pubmed]
  22. Oral lormetazepam in premedication. A comparison with diazepam. Jakobsen, C.J., Jensen, J.J., Hansen, W., Grabe, N. Anaesthesia. (1986) [Pubmed]
  23. Comparative study of lormetazepam and flurazepam in the treatment of insomnia. Melo de Paula, A.J. Clinical therapeutics. (1984) [Pubmed]
  24. ECG activity in the sleep of insomniac patients under the influence of lormetazepam and zopiclone. Jobert, M., Poiseau, E., Jähnig, P., Gaillard, P., Schulz, H. Neuropsychobiology (1995) [Pubmed]
  25. Sleep and wake after benzodiazepine hypnotics: a 20-hour EEG comparison of lormetazepam and flunitrazepam. Timsit-Berthier, M., de Thier, D., Machowsky, R., Mantanus, H., Rousseau, J.C. Current medical research and opinion. (1985) [Pubmed]
  26. Effects of two benzodiazepines on the speed and accuracy of perceptual-motor performance in the elderly. Morgan, K. Psychopharmacology. Supplementum. (1984) [Pubmed]
  27. The effects of lormetazepam on aspects of sleep and early morning performance. Subhan, Z., Hindmarch, I. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
  28. Determination of lormetazepam in plasma by gas chromatography and electron-capture detection. Zecca, L., Ferrario, P., Fraschini, F., Zambotti, F., Zonta, N., Pirola, R. J. Chromatogr. (1986) [Pubmed]
  29. Rebound insomnia and elimination half-life: assessment of individual subject response. Bixler, E.O., Kales, J.D., Kales, A., Jacoby, J.A., Soldatos, C.R. Journal of clinical pharmacology. (1985) [Pubmed]
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