Disease relevance of Nitrosodiethanolamine

• An assessment of the possible risk in human exposure to nitrosodiethanolamine must be based on sound chronic toxicity data [1].
• We report here that when the animals were killed, all bore hepatocellular carcinomas, many of which metastasized at the higher doses, indicating that nitrosodiethanolamine is a carcinogen of considerable potency in the rat [1].
• Mutagenicity of some dialkylnitrosamines, cyclic nitrosamines and N,N-diethanolnitrosamine in Salmonella typhimurium with rat and rabbit nasal, lung and liver S9 homogenates [2].
• Studies on the metabolic activation of diethanolnitrosamine in animal-mediated and in vitro assays using Escherichia coli K-12 343/113 as an indicator [3].

High impact information on Nitrosodiethanolamine

• N-Nitrosomorpholine (NMOR) and N-nitrosodiethanolamine (NDELA) were painted on the clipped upper dorsal skin of male F344 rats [4].
• The results of this study demonstrate that N-nitrosodiethanolamine is organospecific for the Syrian golden hamster nasal cavity and trachea and that it induces tumors in these sites at doses lower than previously reported [5].
• N-Nitrosodiethanolamine was assayed for carcinogenicity in Syrian golden hamsters by s.c. injection, topical application, and oral cavity swabbing [5].
• A dose dependent increase in DNA damage was found in sterilization workers exposed to ethylene oxide and metal workers with exposure towards N-nitrosodiethanolamine [6].
• Faeces and urine of rats were positive in the SCE and negative in the Ames test after treatment with the liver carcinogen N-nitrosodiethanolamine, and negative in the Ames test after treatment with the liver carcinogen N-nitrosodimethylamine [7].

Chemical compound and disease context of Nitrosodiethanolamine

• Cutting fluids can become contaminated with metals (e.g., nickel, Ni) and nitrosamines (e.g., N-nitrosodiethanolamine, NDELA) and there is concern that these classes of contaminants can modulate dermal disposition and ultimately the toxicity of cutting fluid additives, such as irritant biocides (e.g., triazine) [8].
• Methapyrilene hydrochloride (MPHC), N-nitrosomethylaniline (NMA), N-nitrosomethyl-3-carboxypropylamine (NMCP) and N-nitrosodiethanolamine (NDELA) are reputed to be nonmutagenic carcinogens because they are genetically inactive in Salmonella mutagenesis tests but produce cancer in rats [9].

Biological context of Nitrosodiethanolamine

• The percutaneous absorption of N-nitrosodiethanolamine (NDELA), an impurity in many cosmetic products, has been evaluated in diffusion cells using excised human skin [10].
• Biological monitoring of workers exposed to N-nitrosodiethanolamine in the metal industry [11].
• The deamination of DNA bases by three alpha-nitrosaminoaldehydes, butylethanalnitrosamine, methylethanalnitrosamine, and N-nitroso-2-hydroxymorpholine (NHMOR), the direct metabolite of potent animal carcinogen N-nitrosodiethanolamine, was demonstrated by a set of in vitro experiments [12].
• The mutagenicity of N-nitrosodiethanolamine and its mono- and di-acetyl derivatives was tested in the S. typhimurium test system, in cytogenetic studies and in the micronucleus test [13].
• The mutagenicity of N-nitrosodiethanolamine (NDELA) and NDELA monoacetate was tested in vitro on lymphocytes of two healthy probands by determining the frequencies of chromosome aberrations, micronuclei and sister chromatid exchanges (SCE) [14].

Anatomical context of Nitrosodiethanolamine

• Nitrosodiethanolamine is not metabolized by rat liver microsomes, but is metabolized by hepatocytes for Fischer-344 rats [15].
• Mutagenicity of N-nitrosodiethanolamine in the Salmonella/microsome test [16].
• Cytogenetic effects of N-nitrosodiethanolamine (NDELA) and NDELA-monoacetate in human lymphocytes [14].
• DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids [17].
• N-nitrosodiethanolamine (NDELA), which in the literature is described as a non-mutagenic animal carcinogen, could clearly be confirmed as non-mutagenic in the HETMN without showing any disturbing effects on the formation of erythrocytes [18].

Associations of Nitrosodiethanolamine with other chemical compounds

• Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine [19].
• Effects of N-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian golden hamsters [20].
• The numbers and size of GST-P positive foci were significantly higher than the control levels by the treatment with each nitrosamine at full (1/1) and one quarter doses (1/4), excepting nitrosodiethanolamine and by combination of the four chemicals at 1/4 and 1/16 [21].

Gene context of Nitrosodiethanolamine

• The effect of alcohol dehydrogenase (ADH/NAD) from yeast and horse liver was tested on the induction of chromosomal mutations and sister chromatid exchanges (SCE) by N-nitrosodiethanolamine (NDELA) in human lymphocyte cultures [22].
• Increased mutagenicity of N-nitrosodiethanolamine in human lymphocyte cultures after activation by alcohol dehydrogenase [22].
• Biological activity of N-nitrosodiethanolamine and of potential metabolites which may arise after activation by alcohol dehydrogenase in Salmonella typhimurium, in mammalian cells, and in vivo [23].
• Induction of stable p53 oncoprotein and of c-myc overexpression in cultured normal human uroepithelium by radiation and N-nitrosodiethanolamine [24].
• The presence of the carcinogenic N-nitrosodiethanolamine (NDELA; CAS No. 1116-54-7) in cosmetic samples was determined using an etched, C18 modified capillary in the open-tubular capillary electrochromatography technique [25].

Analytical, diagnostic and therapeutic context of Nitrosodiethanolamine

• The oral cavities of 40 hamsters were swabbed three times weekly for 45 weeks with 20 mg of N-nitrosodiethanolamine; the total dose was the same as the highest doses given by s.c. or topical administration [5].
• Although N-nitrosodiethanolamine, a known carcinogen and mutagen, was detected in the reaction mixture by thin-layer chromatography, it may not be the main mutagenic product, because the product was a stable and direct mutagen and its mutagenic activity was destroyed by liver enzymes, unlike N-nitrosodiethanolamine [26].
• Determination of N-nitrosodiethanolamine in cosmetics by gas chromatography with electron capture detection [27].
• Male CD-COBS rats were given N-nitrosodiethanolamine (NDELA) by intravenous or cutaneous administration at a dose of 5 mg/kg [28].
• Weekly subcutaneous injections of N-nitrosodiethanolamine (NDELA) at doses of 1000, 500 and 250 mg/kg body wt for life induced tumors in Syrian hamsters which primarily affected the upper respiratory tract [29].

References