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Chemical Compound Review

Ndela     N,N-bis(2-hydroxyethyl)nitrous amide

Synonyms: CHEMBL1334, CCRIS 463, LS-546, NCI-C55583, AG-D-30198, ...
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Disease relevance of Nitrosodiethanolamine


High impact information on Nitrosodiethanolamine


Chemical compound and disease context of Nitrosodiethanolamine


Biological context of Nitrosodiethanolamine


Anatomical context of Nitrosodiethanolamine


Associations of Nitrosodiethanolamine with other chemical compounds


Gene context of Nitrosodiethanolamine


Analytical, diagnostic and therapeutic context of Nitrosodiethanolamine


  1. Potent carcinogenicity of nitrosodiethanolamine in rats. Lijinsky, W., Reuber, M.D., Manning, W.B. Nature (1980) [Pubmed]
  2. Mutagenicity of some dialkylnitrosamines, cyclic nitrosamines and N,N-diethanolnitrosamine in Salmonella typhimurium with rat and rabbit nasal, lung and liver S9 homogenates. Dahl, A.R. Mutat. Res. (1985) [Pubmed]
  3. Studies on the metabolic activation of diethanolnitrosamine in animal-mediated and in vitro assays using Escherichia coli K-12 343/113 as an indicator. Knasmüller, S., Stehlik, G., Mohn, G. J. Cancer Res. Clin. Oncol. (1986) [Pubmed]
  4. Penetration of rat skin by N-nitrosodiethanolamine and N-nitrosomorpholine. Lijinsky, W., Losikoff, A.M., Sansone, E.B. J. Natl. Cancer Inst. (1981) [Pubmed]
  5. Effects of route of administration and dose on the carcinogenicity of N-nitrosodiethanolamine in the Syrian golden hamster. Hoffman, D., Rivenson, A., Adams, J.D., Juchatz, A., Vinchkoski, N., Hecht, S.S. Cancer Res. (1983) [Pubmed]
  6. Detection of primary DNA damage: applicability to biomonitoring of genotoxic occupational exposure and in clinical therapy. Oesch, F., Hengstler, J.G., Arand, M., Fuchs, J. Pharmacogenetics (1995) [Pubmed]
  7. Mutagenicity of urine and faeces after treatment of rats with known genotoxins. Willems, M.I., de Raat, W.K. Carcinogenesis (1985) [Pubmed]
  8. NDELA and nickel modulation of triazine disposition in skin. Baynes, R.E., Brooks, J.D., Barlow, B.M., Riviere, J.E. Toxicology and industrial health. (2005) [Pubmed]
  9. Genetic activity in yeast assays of reputed nonmutagenic, carcinogenic N-nitroso compounds and methapyrilene hydrochloride. Mehta, R.D., von Borstel, R.C. IARC Sci. Publ. (1984) [Pubmed]
  10. The effect of cosmetic vehicles on the penetration of N-nitrosodiethanolamine through excised human skin. Bronaugh, R.L., Congdon, E.R., Scheuplein, R.J. J. Invest. Dermatol. (1981) [Pubmed]
  11. Biological monitoring of workers exposed to N-nitrosodiethanolamine in the metal industry. Monarca, S., Scassellati-Sforzolini, G., Donato, F., Angeli, G., Spiegelhalder, B., Fatigoni, C., Pasquini, R. Environ. Health Perspect. (1996) [Pubmed]
  12. In vitro DNA deamination by alpha-nitrosaminoaldehydes determined by GC/MS-SIM quantitation. Park, M., Loeppky, R.N. Chem. Res. Toxicol. (2000) [Pubmed]
  13. Mutagenicity of n-nitrosodiethanolamine and its acetyl derivatives. Gilbert, P., Fabry, L., Rollmann, B., Lombart, P., Rondelet, J., Poncelet, F., Leonard, A., Mercier, M. Mutat. Res. (1981) [Pubmed]
  14. Cytogenetic effects of N-nitrosodiethanolamine (NDELA) and NDELA-monoacetate in human lymphocytes. Dittberner, U., Eisenbrand, G., Zankl, H. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  15. The metabolism of nitrosodi-n-propylamine, nitrosodiallylamine and nitrosodiethanolamine. Farrelly, J.G., Stewart, M.L., Lijinsky, W. Carcinogenesis (1984) [Pubmed]
  16. Mutagenicity of N-nitrosodiethanolamine in the Salmonella/microsome test. Mori, Y., Yamazaki, H., Konishi, Y. Mutat. Res. (1987) [Pubmed]
  17. DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U., Oesch, F. Mutat. Res. (1995) [Pubmed]
  18. Investigating genotoxic and hematotoxic effects of N-nitrosodimethylamine, N-nitrosodiethylamine and N-nitrosodiethanolamine in the hen's egg-micronucleus test (HET-MN). Wolf, T., Niehaus-Rolf, C., Luepke, N.P. Food Chem. Toxicol. (2003) [Pubmed]
  19. Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine. Saghir, S.A., Brzak, K.A., Markham, D.A., Bartels, M.J., Stott, W.T. Regulatory toxicology and pharmacology : RTP. (2005) [Pubmed]
  20. Effects of N-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian golden hamsters. Hilfrich, J., Schmeltz, I., Hoffmann, D. Cancer Lett. (1978) [Pubmed]
  21. Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Futakuchi, M., Lijinsky, W., Hasegawa, R., Hirose, M., Ito, N., Shirai, T. Cancer Lett. (1996) [Pubmed]
  22. Increased mutagenicity of N-nitrosodiethanolamine in human lymphocyte cultures after activation by alcohol dehydrogenase. Henn, I., Eisenbrand, G., Zankl, H. J. Cancer Res. Clin. Oncol. (1989) [Pubmed]
  23. Biological activity of N-nitrosodiethanolamine and of potential metabolites which may arise after activation by alcohol dehydrogenase in Salmonella typhimurium, in mammalian cells, and in vivo. Denkel, E., Pool, B.L., Schlehofer, J.R., Eisenbrand, G. J. Cancer Res. Clin. Oncol. (1986) [Pubmed]
  24. Induction of stable p53 oncoprotein and of c-myc overexpression in cultured normal human uroepithelium by radiation and N-nitrosodiethanolamine. Mothersill, C., Harney, J., Seymour, C.B. Radiat. Res. (1994) [Pubmed]
  25. Screening method for determining the presence of N-nitrosodiethanolamine in cosmetics by open-tubular capillary electrochromatography. Matyska, M.T., Pesek, J.J., Yang, L. Journal of chromatography. A. (2000) [Pubmed]
  26. Carcinogenicity of triethanolamine in mice and its mutagenicity after reaction with sodium nitrite in bacteria. Hoshino, H., Tanooka, H. Cancer Res. (1978) [Pubmed]
  27. Determination of N-nitrosodiethanolamine in cosmetics by gas chromatography with electron capture detection. Rollmann, B., Lombart, P., Rondelet, J., Mercier, M. J. Chromatogr. (1981) [Pubmed]
  28. Kinetics and bioavailability of N-nitrosodiethanolamine after intravenous and cutaneous administration to rats. Airoldi, L., Macri, A., Bonfanti, M., Bonati, M., Fanelli, R. Food Chem. Toxicol. (1984) [Pubmed]
  29. The carcinogenicity of N-nitrosodiethanolamine, an environmental pollutant, in Syrian hamsters. Pour, P., Wallcave, L. Cancer Lett. (1981) [Pubmed]
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