Disease relevance of Primicarbe

• Addition of sediment thus reduced the toxicity of pirimicarb toward Daphnia magna.Pirimicarb was accumulated 12-16 times (5-7% of total) in the sediment, but the water concentrations of pirimicarb were not reduced significantly during the experiment, due to the small amount of sediment used [1].

High impact information on Primicarbe

• Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb: effect of nonylphenolethoxylate and protective gloves [2].
• We introduced incrementally the single substitution W290A and a 26 amino acid long insertion at the 297 location in the Nippostrongylus brasiliensis acetylcholinesterase B sequence and analysed in vitro the induced changes in the hydrolysis rate of three hemi-substrates: pirimicarb, paraoxon methyl and omethoate [3].
• However, a single amino acid substitution of Ser431Phe on MpAchE2 was found in the pirimicarb resistant strains [4].
• An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae [4].
• The deduced amino acid sequence of MpAChE1 cDNA was identical between the pirimicarb susceptible and resistant strains [4].

Biological context of Primicarbe

• The hydrolysis of pirimicarb was not affected by montmorillonite [5].
• Biological monitoring of exposure to pirimicarb: hydroxypyrimidines in human urine [6].
• The reduced bioavailability of pirimicarb may derive from humic acid and related compounds released from the sediment [1].
• In acute tests, tadpoles were exposed to relatively high concentrations of azoxystrobin, cyanazine, esfenvalerate, MCPA ([4-chloro-2-methylphenoxy] acetic acid), permethrin, and pirimicarb for 72 h [7].

Anatomical context of Primicarbe

• Effect of the insecticidal carbamate derivatives (carbofuran, pirimicarb, aldicarb) on the activity of acetylcholinesterase in tissues from pregnant rats and fetuses [8].

Associations of Primicarbe with other chemical compounds

• Methomyl, pirimicarb, propamocarb, and iprodion weakly stimulated aromatase activity [9].
• Acute and chronic effects of pulse exposure of Daphnia magna to dimethoate and pirimicarb [10].
• Experiments were carried out in the laboratory to assess the insecticidal effect on Myzus persicae Sulzer of different oils applied alone or combined with imidacloprid or pirimicarb [11].
• With respect to biological monitoring, methods were developed for the analysis of metabolites in urine of captan, pirimicarb, zineb and maneb and the soil fumigant dichloropropene [12].
• Ethiofencarb and pirimicarb, widely used insecticides, were investigated for hepatocarcinogenesis-modifying effects using a medium-term bioassay system for carcinogens [13].

Gene context of Primicarbe

• Furthermore, site-directed mutagenesis of the serine residue at position 431 in ace1 from a pirimicarb-susceptible clone of A gossypii conferred insensitivity to pirimicarb [14].
• Differential response of Apis mellifera acetylcholinesterase towards pirimicarb [15].

Analytical, diagnostic and therapeutic context of Primicarbe

• Comparison of capillary electrochromatography with high-performance liquid chromatography for the analysis of pirimicarb and related compounds [16].
• Exposure of greenhouse chrysanthemum workers to the pesticide pirimicarb was measured by the Video Imaging Technique to Assess Exposure (VITAE) along with air monitoring and biological assessment techniques [17].
• Serological tests revealed the presence of an IgG antibody active only in the presence of pirimicarb [18].

References