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Chemical Compound Review

PubChem2215     4-chlorobenzene-1,2-diol

Synonyms: SureCN70036, CPD-9152, ACMC-1CCU9, AG-C-91911, AG-E-56644, ...
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Disease relevance of C02375


High impact information on C02375


Chemical compound and disease context of C02375


Biological context of C02375


Associations of C02375 with other chemical compounds


Gene context of C02375

  • A peroxidase and another enzymatic activity referred to as a polyphenol oxidase were found to be involved in the oxidation of 4-chlorocatechol to 4-chloro-1,2-benzoquinone, i.e. in the production of highly reactive substrates for pigment formation [16].

Analytical, diagnostic and therapeutic context of C02375


  1. Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. Ferraroni, M., Seifert, J., Travkin, V.M., Thiel, M., Kaschabek, S., Scozzafava, A., Golovleva, L., Schlömann, M., Briganti, F. J. Biol. Chem. (2005) [Pubmed]
  2. Chlorocatechol detection based on a clc operon/reporter gene system. Guan, X., Ramanathan, S., Garris, J.P., Shetty, R.S., Ensor, M., Bachas, L.G., Daunert, S. Anal. Chem. (2000) [Pubmed]
  3. Cloning, expression, and nucleotide sequence of the Pseudomonas aeruginosa 142 ohb genes coding for oxygenolytic ortho dehalogenation of halobenzoates. Tsoi, T.V., Plotnikova, E.G., Cole, J.R., Guerin, W.F., Bagdasarian, M., Tiedje, J.M. Appl. Environ. Microbiol. (1999) [Pubmed]
  4. Molecular cloning and characterization of catechol 2,3-dioxygenases from biphenyl/polychlorinated biphenyls-degrading bacteria. Chang, H., Lee, J., Roh, S., Kim, S.R., Min, K.R., Kim, C.K., Kim, E.G., Kim, Y. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  5. Metabolism of 4-chlorophenol by Azotobacter sp. GP1: structure of the meta cleavage product of 4-chlorocatechol. Wieser, M., Eberspächer, J., Vogler, B., Lingens, F. FEMS Microbiol. Lett. (1994) [Pubmed]
  6. Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP. Ferraroni, M., Solyanikova, I.P., Kolomytseva, M.P., Scozzafava, A., Golovleva, L., Briganti, F. J. Biol. Chem. (2004) [Pubmed]
  7. Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol. Ferraroni, M., Kolomytseva, M.P., Solyanikova, I.P., Scozzafava, A., Golovleva, L.A., Briganti, F. J. Mol. Biol. (2006) [Pubmed]
  8. The clc element of Pseudomonas sp. strain B13, a genomic island with various catabolic properties. Gaillard, M., Vallaeys, T., Vorhölter, F.J., Minoia, M., Werlen, C., Sentchilo, V., Pühler, A., van der Meer, J.R. J. Bacteriol. (2006) [Pubmed]
  9. New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1. Nikodem, P., Hecht, V., Schlömann, M., Pieper, D.H. J. Bacteriol. (2003) [Pubmed]
  10. Pseudomonas aeruginosa 142 uses a three-component ortho-halobenzoate 1,2-dioxygenase for metabolism of 2,4-dichloro- and 2-chlorobenzoate. Romanov, V., Hausinger, R.P. J. Bacteriol. (1994) [Pubmed]
  11. Molecular cloning of 3-phenylcatechol dioxygenase involved in the catabolic pathway of chlorinated biphenyl from Pseudomonas putida and its expression in Escherichia coli. Khan, A., Tewari, R., Walia, S. Appl. Environ. Microbiol. (1988) [Pubmed]
  12. Effect of dietary protein and sulfur-containing amino acids on urinary metabolites in rats injected with chlorobenzene. Goto, H., Yoshida, M., Nakazono, N. The Journal of toxicological sciences. (1993) [Pubmed]
  13. Microbial mineralization of ring-substituted anilines through an ortho-cleavage pathway. Zeyer, J., Wasserfallen, A., Timmis, K.N. Appl. Environ. Microbiol. (1985) [Pubmed]
  14. Differences in urinary monochlorobenzene metabolites between rats and humans. Ogata, M., Shimada, Y. International archives of occupational and environmental health. (1983) [Pubmed]
  15. Cloning and nucleotide sequence analysis of xylE gene responsible for meta-cleavage of 4-chlorocatechol from Pseudomonas sp. S-47. Noh, S.J., Kim, Y., Min, K.H., Karegoudar, T.B., Kim, C.K. Mol. Cells (2000) [Pubmed]
  16. Biosynthesis and cytoplasmic accumulation of a chlorinated catechol pigment during 3-chlorobenzoate aerobic co-metabolism in Pseudomonas fluorescens. Fava, F., Di Gioia, D., Romagnoli, C., Marchetti, L., Mares, D. Arch. Microbiol. (1993) [Pubmed]
  17. Quantitation of urinary chlorobenzene metabolites by HPLC: concentrations of 4-chlorocatechol and chlorophenols in urine and of chlorobenzene in biological specimens of subjects exposed to chlorobenzene. Ogata, M., Taguchi, T., Hirota, N., Shimada, Y., Nakae, S. International archives of occupational and environmental health. (1991) [Pubmed]
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