Disease relevance of Palacos R

• The bone resorption activity of the co-culture supernatants was significantly greater than the control (U937 cells without particles) for particles of CMW 1RO, CMW copolymer bone cement 1, CMW copolymer bone cement 2 and Palacos R (P < 0.05, ANOVA) [1].
• We measured the formation of a Staphylococcus aureus biofilm in vitro on unloaded and gentamicin-loaded bone cements (CMW3 and Palacos R) and related the formation to antibiotic release rates [2].
• In conclusion, the use of liquid pamidronate mixed with the acrylic bone cement Palacos R in order to reduce osteolysis is not recommended because of its effect on the mechanical properties of Palacos R [3].
• Immediately after an operation in which acrylic bone cement (Palacos-R) sterilized with ethylene oxide was implanted for stabilization of the cervical spine, the patient developed massive edema of the larynx, pharynx, and tongue, suggesting Quincke's edema [4].

High impact information on Palacos R

• The prosthesis was performed in the first group with 'Palacos R plus gentamicin' (normal viscosity), manufactured by Schering, and in the second group with 'Cerafix genta R' (low viscosity) manufactured by Ceraver-Osteal [5].
• The early apoptotic events of culture were evaluated after 4 and 24 h in PHA-stimulated lymphocytes: at 4 h three cements, namely Zimmer-dough type, Palacos R and CMW-1, increased significantly the percentage of apoptotic cells, while at 24 h no differences were found [6].
• The focus of this work was a delineation of the effect of the method of sterilization (gamma-irradiation versus exposure to ethylene oxide (EtO) gas) of the powder constituents of Palacos R bone cement on the molecular weight, quasi-static tensile and compressive properties and fatigue performance of the fully polymerized material [7].
• Six vacuum mixing systems, Cemvac, Merck, Mitvac, Optivac, Osteobond, and Stryker, were tested using prechilled Palacos R bone cement to investigate the reduction of porosity compared to mixing at atmospheric pressure [8].
• MATERIAL AND METHODS: We therefore tested 6 vacuum mixing systems (Palamix, Summit, Cemvac, Optivac, Vacumix, MixOR) in combination with 6 cement brands (Palacos R, Simplex P, CWM 1, CWM 2000, Palamed G, VersaBond) concerning their reliability, user-friendliness, porosity and bending strength [9].

Biological context of Palacos R

• The Wilcoxon signed rank test showed Palacos R and L.V.C. induced a significant decrease of platelet number compared with the negative control [10].

Anatomical context of Palacos R

• Cranioplasty with Palacos R in reconstruction of frontal sinus defects [11].
• In the first series, the specimens were prepared from Palacos R cement mantles retrieved from cemented total hip joint replacements after 11 months, 11 years, and 21 years in vivo [12].
• The osteolytic response of macrophages to challenge with particles of Simplex P, Endurance, Palacos R, and Vertebroplastic bone cement particles in vitro [13].

Associations of Palacos R with other chemical compounds

• The aim of this in vitro study was to compare the elution characteristics of vancomycin alone and in combination with imipenem-cilastatin from 3 acrylic bone-cements (CMW1 [DePuy International, Blackpool, UK], Palacos R [Schering-Plough, Wehrheim, Germany], and Simplex P [Howmedica International, London, UK]) [14].

Gene context of Palacos R

• Particles of Palacos R and Endurance stimulated enhanced production of TNF-alpha, IL-1-beta, and IL-6 (p<0.05; ANOVA) [13].

Analytical, diagnostic and therapeutic context of Palacos R

• Influence of antibiotic impregnation on the fatigue life of Simplex P and Palacos R acrylic bone cements, with and without centrifugation [15].
• This revision arthroplasty comprises, in one stage, excision of soft tissue, removal of implant and cement, replacement with an appropriate implant using Palacos R acrylic cement loaded with an appropriate antibiotic and, more recently, systemic antibiotics [16].
• Palamed G compared with Palacos R with gentamicin in Charnley total hip replacement: A RANDOMISED, RADIOSTEREOMETRIC STUDY OF 60 HIPS [17].
• The result of this study indicates that VersaBond bone cement will perform at least equally as well as Palacos R in total knee replacement as regards as aseptic loosening [18].

References