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Chemical Compound Review

ANW-54578     3-(2-nitroimidazol-1- yl)propane-1,2-diol

Synonyms: NSC-261036, AC1L1AFC, AK-58421, KB-10183, CTK8B6841, ...
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Disease relevance of SR 1530


High impact information on SR 1530


Biological context of SR 1530


Anatomical context of SR 1530


Gene context of SR 1530

  • A further study with desmethylmisonidazole given to 11 additional patients showed a similar range of tumour penetration but lower concentrations in CSF and cyst fluid (10-20%) [13].

Analytical, diagnostic and therapeutic context of SR 1530


  1. Pharmacokinetics of the hypoxic radiosensitizers misonidazole and demethylmisonidazole after intraperitoneal administration in humans. Gianni, L., Jenkins, J.F., Greene, R.F., Lichter, A.S., Myers, C.E., Collins, J.M. Cancer Res. (1983) [Pubmed]
  2. Radiosensitization of the RIF-1 murine flank tumor by desmethylmisonidazole (Ro 05 9963) during interstitial brachytherapy. Bernstein, M., Gutin, P.H., Deen, D.F., Weaver, K.A., Levin, V.A., Barcellos, M.H. Int. J. Radiat. Oncol. Biol. Phys. (1982) [Pubmed]
  3. The current status of drug development of hypoxic cell radiosensitizers and their potential role in gynecologic oncology. Coleman, C.N., Ballon, S.C., Howes, A.E., Martinez, A., Halsey, J., Hirst, V.K. Gynecol. Oncol. (1984) [Pubmed]
  4. Comparison of the fate of misonidazole (RO 07-0582) and its metabolite desmethylmisonidazole (RO 05-9963), two hypoxic cell radiosensitizers: penetration properties in tumor bearing rats. Akel, G., Canal, P., Mockey, E., Vandevoorde, E., Laurent, F., Soula, G. Journal de pharmacologie. (1983) [Pubmed]
  5. Evaluation of desmethylmisonidazole-induced neurotoxicity in the rat using brainstem auditory evoked potentials. Edwards, M.S., Gordon, D.G., Levin, V.A. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  6. Effects of the xanthine oxidase inhibitor allopurinol on the renal clearance of nitroimidazoles. Workman, P., White, R.A. Biochem. Pharmacol. (1982) [Pubmed]
  7. Initial pharmacology and toxicology of intravenous desmethylmisonidazole. Coleman, C.N., Wasserman, T.H., Phillips, T.L., Strong, J.M., Urtasun, R.C., Schwade, J.G., Johnson, R.J., Zagars, G. Int. J. Radiat. Oncol. Biol. Phys. (1982) [Pubmed]
  8. Structure-pharmacokinetic relationships for misonidazole analogues in mice. Workman, P., Brown, J.M. Cancer Chemother. Pharmacol. (1981) [Pubmed]
  9. Renal elimination of the hypoxic cell radiosensitizer misonidazole in Wistar rats: influence of some drugs on its excretion. Akel, G., Canal, P., Soula, G. European journal of drug metabolism and pharmacokinetics. (1985) [Pubmed]
  10. The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid. Dische, S., Saunders, M.I., Riley, P.J., Hauck, J., Bennett, M.H., Stratford, M.R., Minchinton, A.I. Br. J. Cancer (1981) [Pubmed]
  11. Nitroimidazole inhibition of lactate production in CHO cells. Chao, C.F., Subjeck, J.R., Johnson, R.J. Int. J. Radiat. Oncol. Biol. Phys. (1982) [Pubmed]
  12. Pharmacokinetics of 2-nitroimidazole hypoxic cell radiosensitizers in rodent peripheral nervous tissue. Sasai, K., Shibamoto, Y., Takahashi, M., Ito, T., Nishimoto, S., Abe, M. Int. J. Radiat. Biol. (1990) [Pubmed]
  13. The penetration of misonidazole and desmethylmisonidazole into brain tumours and other central nervous system tissues in man. Bleehen, N.M., Grant, R.M., Jones, D.H., Roberts, J.T., Workman, P., Gleave, J.R., Hardy, D.G., Holmes, A.E. The British journal of radiology. (1983) [Pubmed]
  14. Studies on the O-demethylation of misonidazole by rat liver microsomes. Shoemaker, D.D., McManus, M.E., Hoerauf, R., Strong, J.M. Cancer treatment reports. (1982) [Pubmed]
  15. Desmethylmisonidazole (Ro 05-9963): clinical pharmacokinetics after multiple oral administration. Stratford, M.R., Minchinton, A.I., Dische, S., Saunders, M.I., Anderson, P. Int. J. Radiat. Oncol. Biol. Phys. (1982) [Pubmed]
  16. Simultaneous determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography. Meering, P.G., Maes, R.A. J. Chromatogr. (1981) [Pubmed]
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