The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Salufer     disodium hexafluorosilicon

Synonyms: Safsan, HSDB 770, Super prodan, LTBB002782, AC1L1EOA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of disodium hexafluorosilicon


High impact information on disodium hexafluorosilicon


Biological context of disodium hexafluorosilicon

  • Thus, the use of prodan in studies of the myosin ATPase offers a new and promising approach not only to monitoring the ATPase reaction but also to investigating the structural changes during ATP hydrolysis [6].
  • The changes in molecular structure in the junction that could be responsible for the altered PRODAN emission are discussed [7].
  • Geometric mean PbB concentrations for each water fluoridation method were 2.40 microg/dL (sodium silicofluoride), 2.34 microg/dL (hydrofluosilicic acid), 1.78 microg/dL (sodium fluoride), 2.24 microg/dL (natural fluoride and no fluoride), and 2.14 microg/dL (unknown/mixed status) [8].
  • Since the lambdamax reflects the solvent property around the probe molecules, we could speculate on the location of the Prodan molecules in the bilayer membranes; in the Lalpha phase of the lipid bilayer, the Prodan molecules distribute around the phosphate of the lipids (i.e. the polar region) [9].

Anatomical context of disodium hexafluorosilicon


Associations of disodium hexafluorosilicon with other chemical compounds

  • As DPPC undergoes the ethanol-induced phase transition from the noninterdigitated to the fully interdigitated gel state, Kp for Prodan and Acdan decreases by a factor of 5 and 2, respectively, whereas Kp for Laurdan exhibits no detectable changes with ethanol [14].
  • Among these three probes, Prodan fluorescence reflects most correctly the ethanol-induced lipid interdigitation [14].
  • The effects of hydrostatic pressure on the location of 6-propionyl-2-(dimethylamino)naphthalene (PRODAN), an environmentally sensitive fluorescent probe, in phosphatidylcholine lipid bilayers have been studied by Fourier-transform infrared spectroscopy (FT-IR) over the pressure range of 0.001-25 kbar [12].
  • Steady-state fluorescence of 6-propionyl-2-(dimethylamino)naphthalene (Prodan) has been employed to study the interacting effects between ethanol and pressure on the formation of the fully interdigitated dipalmitoylphosphatidylcholine (DPPC) [15].
  • Additionally, our results demonstrate that the Prodan molecule conjugated to F-actin is completely immobile during its fluorescence lifetime, exhibits an increase in the resonance energy transfer (RET) from tryptophan residues compared to that observed in G-actin, and shows evidence of homologous RET within the polymer [16].

Gene context of disodium hexafluorosilicon

  • The novel rinse consisted of two solutions mixed just before application: Part A contained calcium chloride and sodium acetate; part B contained a hydrolyzable source of fluoride (sodium hexafluorosilicate) and sodium phosphate [17].
  • The fluorescence emission of two probes, TNS (anionic) and PRODAN (nonionic), allows for the analysis of the micropolarity and microviscosity of the different microenvironments present in aqueous surfactant solutions where the above-mentioned vesicle and prevesicle aggregates are present [18].
  • Hydrophobicity was lower at pH 3.0 than at other pH values for all proteins measured by PRODAN, whereas the values measured by ANS and CPA at pH 3.0 were quite high compared to those at other pH values, suggesting the influence of electrostatic interactions on anionic probe-protein binding [19].
  • Human osteogenic sarcoma (HOS) cells were the most sensitive to sodium fluorosilicate treatment [1].
  • In conclusion, sodium fluorosilicate induces apoptosis in HOS cells through decrease in Bcl-2, the release of cytochrome c to the cytosol and activation of caspase-3 [1].

Analytical, diagnostic and therapeutic context of disodium hexafluorosilicon

  • Based on the agreement between oxygen binding curves and fluorescence titration we concluded that Prodan monitors a conformational transition of the allosteric unit [3].


  1. Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. Song, J.S., Park, Y.D., Hyun, J.W., Kim, J.H. Anticancer Res. (2005) [Pubmed]
  2. p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix. Johnsson, N., Marriott, G., Weber, K. EMBO J. (1988) [Pubmed]
  3. Cooperative transition in the conformation of 24-mer tarantula hemocyanin upon oxygen binding. Erker, W., Beister, U., Decker, H. J. Biol. Chem. (2005) [Pubmed]
  4. Differential Detection of Phospholipid Fluidity, Order, and Spacing by Fluorescence Spectroscopy of Bis-pyrene, Prodan, Nystatin, and Merocyanine 540. Wilson-Ashworth, H.A., Bahm, Q., Erickson, J., Shinkle, A., Vu, M.P., Woodbury, D., Bell, J.D. Biophys. J. (2006) [Pubmed]
  5. Spatial relationship between the prodan site, Trp-214, and Cys-34 residues in human serum albumin and loss of structure through incremental unfolding. Krishnakumar, S.S., Panda, D. Biochemistry (2002) [Pubmed]
  6. Prodan fluorescence reflects differences in nucleotide-induced conformational states in the myosin head and allows continuous visualization of the ATPase reactions. Hiratsuka, T. Biochemistry (1998) [Pubmed]
  7. Polarity decrease at the adhesive junction between two model membranes containing gangliosides. Brewer, G.J. Biochemistry (1992) [Pubmed]
  8. Blood lead concentrations in children and method of water fluoridation in the United States, 1988-1994. Macek, M.D., Matte, T.D., Sinks, T., Malvitz, D.M. Environ. Health Perspect. (2006) [Pubmed]
  9. Effect of pressure on the Prodan fluorescence in bilayer membranes of phospholipids with varying acyl chain lengths. Kusube, M., Matsuki, H., Kaneshina, S. Colloids and surfaces. B, Biointerfaces. (2005) [Pubmed]
  10. Probing the interactions of alcohols with biological membranes with the fluorescent probe Prodan. Rottenberg, H. Biochemistry (1992) [Pubmed]
  11. Effects of hydrostatic pressure on the location of PRODAN in lipid bilayers and cellular membranes. Chong, P.L. Biochemistry (1988) [Pubmed]
  12. Effects of hydrostatic pressure on the location of PRODAN in lipid bilayers: a FT-IR study. Chong, P.L., Capes, S., Wong, P.T. Biochemistry (1989) [Pubmed]
  13. Interaction of myosin.ADP.fluorometal complexes with fluorescent probes and direct observation using quick-freeze deep-etch electron microscopy. Maruta, S., Uyehara, Y., Aihara, T., Katayama, E. J. Biochem. (2004) [Pubmed]
  14. Effect of ethanol-induced lipid interdigitation on the membrane solubility of Prodan, Acdan, and Laurdan. Zeng, J., Chong, P.L. Biophys. J. (1995) [Pubmed]
  15. Interactions between pressure and ethanol on the formation of interdigitated DPPC liposomes: a study with Prodan fluorescence. Zeng, J.W., Chong, P.L. Biochemistry (1991) [Pubmed]
  16. Spectroscopic and functional characterization of an environmentally sensitive fluorescent actin conjugate. Marriott, G., Zechel, K., Jovin, T.M. Biochemistry (1988) [Pubmed]
  17. In vivo fluoride concentrations measured for two hours after a NaF or a novel two-solution rinse. Vogel, G.L., Mao, Y., Carey, C.M., Chow, L.C., Takagi, S. J. Dent. Res. (1992) [Pubmed]
  18. Electrochemical, microscopic, and spectroscopic characterization of prevesicle nanostructures and vesicles on mixed cationic surfactant systems. Aicart, E., Del Burgo, P., Llorca, O., Junquera, E. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  19. Comparison of protein surface hydrophobicity measured at various pH values using three different fluorescent probes. Alizadeh-Pasdar, N., Li-Chan, E.C. J. Agric. Food Chem. (2000) [Pubmed]
WikiGenes - Universities