Chemical Compound Review:
AC1MHWSO (2R)-N-methyl-1-oxo-2- pyridin-3-yl-thiane...
Synonyms:
CHEMBL76358, RP-49356, RP-52891, LS-178092, RP 49356, ...
- Altered control of vascular tone by adenosine triphosphate-sensitive potassium channels in rats with cirrhosis. Moreau, R., Komeichi, H., Kirstetter, P., Ohsuga, M., Cailmail, S., Lebrec, D. Gastroenterology (1994)
- Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. Auchampach, J.A., Maruyama, M., Cavero, I., Gross, G.J. Circulation (1992)
- Protective effects of the K+ ATP channel opener, aprikalim, against free radicals in isolated rabbit hearts. Pignac, J., Lacaille, C., Dumont, L. Free Radic. Biol. Med. (1996)
- Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats. Sobey, C.G., Heistad, D.D., Faraci, F.M. Stroke (1997)
- Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart. Guo, A.C., Diacono, J., Feuvray, D. Cardiovasc. Res. (1994)
- Contributory mechanisms for the beneficial effects of myocyte preconditioning during cardioplegic arrest. O, S.J., Zellner, J.L., Cox, M.H., Hebbar, L., Brothers, T.E., Mukherjee, R., Tempel, G.E., Dorman, B.H., Crawford, F.A., Spinale, F.G. Circulation (1996)
- ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M. Circ. Res. (1994)
- Effects of several potassium channel openers and glibenclamide on the uterus of the rat. Piper, I., Minshall, E., Downing, S.J., Hollingsworth, M., Sadraei, H. Br. J. Pharmacol. (1990)
- Hyperpolarized cardiac arrest with a potassium-channel opener, aprikalim. Maskal, S.L., Cohen, N.M., Hsia, P.W., Wechsler, A.S., Damiano, R.J. J. Thorac. Cardiovasc. Surg. (1995)
- Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation. Warltier, D.C., Auchampach, J.A., Gross, G.J. Journal of cardiac surgery. (1993)
- ATP gated potassium channels in acute myocardial hibernation and reperfusion. Offstad, J., Kirkebøen, K.A., Ilebekk, A., Downing, S.E. Cardiovasc. Res. (1994)
- Inhibition of vasoconstriction by potassium channel opener aprikalim in human conduit arteries used as bypass grafts. He, G.W., Yang, C.Q. British journal of clinical pharmacology. (1997)
- Aprikalim: radioimmunoassay and pharmacokinetic studies in mouse, monkey, and dog. Chevalier, P., Rouillard, C., Montay, G., Frydman, A. Journal of pharmaceutical sciences. (1994)
- Elective cardiac arrest with a hyperpolarizing adenosine triphosphate-sensitive potassium channel opener. A novel form of myocardial protection? Cohen, N.M., Wise, R.M., Wechsler, A.S., Damiano, R.J. J. Thorac. Cardiovasc. Surg. (1993)
- Apparent competition between ATP and the potassium channel opener RP 49356 on ATP-sensitive K+ channels of cardiac myocytes. Thuringer, D., Escande, D. Mol. Pharmacol. (1989)
- RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine. Raeburn, D., Brown, T.J. J. Pharmacol. Exp. Ther. (1991)
- The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes. Auchampach, J.A., Maruyama, M., Cavero, I., Gross, G.J. J. Pharmacol. Exp. Ther. (1991)
- Effects of P1060 and aprikalim on whole-cell currents in rat portal vein; inhibition by glibenclamide and phentolamine. Ibbotson, T., Edwards, G., Noack, T., Weston, A.H. Br. J. Pharmacol. (1993)
- Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs. Auchampach, J.A., Gross, G.J. Eur. Heart J. (1993)
- Cellular pharmacology of potassium channel openers in vascular smooth muscle. Quast, U., Guillon, J.M., Cavero, I. Cardiovasc. Res. (1994)
- Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats. Pratz, J., Mondot, S., Montier, F., Cavero, I. J. Pharmacol. Exp. Ther. (1991)
- Effects of two K+ channel openers, aprikalim and pinacidil, on hypoxic pulmonary vasoconstriction. Dumas, J.P., Dumas, M., Sgro, C., Advenier, C., Giudicelli, J.F. Eur. J. Pharmacol. (1994)
- Aprikalim reduces the Na+-Ca2+ exchange outward current enhanced by hyperkalemia in rat ventricular myocytes. Li, H.Y., Wu, S., He, G.W., Wong, T.M. Ann. Thorac. Surg. (2002)
- Global ischemia impairs ATP-sensitive K+ channel function in cerebral arterioles in piglets. Bari, F., Louis, T.M., Meng, W., Busija, D.W. Stroke (1996)
- Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin. Borg, C., Mondot, S., Mestre, M., Cavero, I. J. Pharmacol. Exp. Ther. (1991)
- Effects of potassium channel opener aprikalim on the receptor-mediated vasoconstriction in the human internal mammary artery. Liu, M.H., Floten, H.S., Furnary, A.P., Yim, A.P., He, G.W. Ann. Thorac. Surg. (2001)
- Two different types of potassium channels in human skeletal muscle activated by potassium channel openers. Quasthoff, S., Franke, C., Hatt, H., Richter-Turtur, M. Neurosci. Lett. (1990)
- The myocardial lesions produced by the potassium channel opener aprikalim in monkeys and rats are prevented by blockade of cardiac beta-adrenoceptors. Belin, V., Hodge, T., Picaut, P., Jordan, R., Algate, C., Gosselin, S., Nohynek, G., Cavero, I. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996)