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Chemical Compound Review

ARUNDINE     3-(1H-indol-3-ylmethyl)-1H- indole

Synonyms: CPDQT-424, PubChem8119, CHEMBL446452, SureCN325162, CCRIS 5806, ...
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Disease relevance of CCRIS 5806


High impact information on CCRIS 5806


Chemical compound and disease context of CCRIS 5806


Biological context of CCRIS 5806


Anatomical context of CCRIS 5806


Associations of CCRIS 5806 with other chemical compounds


Gene context of CCRIS 5806


Analytical, diagnostic and therapeutic context of CCRIS 5806


  1. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. Rahman, K.W., Li, Y., Wang, Z., Sarkar, S.H., Sarkar, F.H. Cancer Res. (2006) [Pubmed]
  2. Down-regulation of Androgen Receptor by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Both Hormone-Sensitive LNCaP and Insensitive C4-2B Prostate Cancer Cells. Bhuiyan, M.M., Li, Y., Banerjee, S., Ahmed, F., Wang, Z., Ali, S., Sarkar, F.H. Cancer Res. (2006) [Pubmed]
  3. Fas-Mediated Apoptosis in Cholangiocarcinoma Cells Is Enhanced by 3,3'-Diindolylmethane through Inhibition of AKT Signaling and FLICE-Like Inhibitory Protein. Chen, Y., Xu, J., Jhala, N., Pawar, P., Zhu, Z.B., Ma, L., Byon, C.H., McDonald, J.M. Am. J. Pathol. (2006) [Pubmed]
  4. Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Leong, H., Riby, J.E., Firestone, G.L., Bjeldanes, L.F. Mol. Endocrinol. (2004) [Pubmed]
  5. 3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells. Gong, Y., Firestone, G.L., Bjeldanes, L.F. Mol. Pharmacol. (2006) [Pubmed]
  6. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Hestermann, E.V., Brown, M. Mol. Cell. Biol. (2003) [Pubmed]
  7. 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Gong, Y., Sohn, H., Xue, L., Firestone, G.L., Bjeldanes, L.F. Cancer Res. (2006) [Pubmed]
  8. Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450. Crowell, J.A., Page, J.G., Levine, B.S., Tomlinson, M.J., Hebert, C.D. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  9. Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. Rahman, K.W., Sarkar, F.H. Cancer Res. (2005) [Pubmed]
  10. Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane. Chang, X., Firestone, G.L., Bjeldanes, L.F. Carcinogenesis (2006) [Pubmed]
  11. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., Safe, S. Carcinogenesis (2006) [Pubmed]
  12. Therapeutic activity of 3,3'-diindolylmethane on prostate cancer in an in vivo model. Nachshon-Kedmi, M., Fares, F.A., Yannai, S. Prostate (2004) [Pubmed]
  13. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Jellinck, P.H., Forkert, P.G., Riddick, D.S., Okey, A.B., Michnovicz, J.J., Bradlow, H.L. Biochem. Pharmacol. (1993) [Pubmed]
  14. 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. Tadi, K., Chang, Y., Ashok, B.T., Chen, Y., Moscatello, A., Schaefer, S.D., Schantz, S.P., Policastro, A.J., Geliebter, J., Tiwari, R.K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  15. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Wattenberg, L.W., Loub, W.D. Cancer Res. (1978) [Pubmed]
  16. Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Pappa, G., Lichtenberg, M., Iori, R., Barillari, J., Bartsch, H., Gerhäuser, C. Mutat. Res. (2006) [Pubmed]
  17. Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. Tilton, S.C., Givan, S.A., Pereira, C.B., Bailey, G.S., Williams, D.E. Toxicol. Sci. (2006) [Pubmed]
  18. Cell signaling pathways altered by natural chemopreventive agents. Sarkar, F.H., Li, Y. Mutat. Res. (2004) [Pubmed]
  19. Endocrine disruption by indole-3-carbinol and tamoxifen: blockage of ovulation. Gao, X., Petroff, B.K., Oluola, O., Georg, G., Terranova, P.F., Rozman, K.K. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  20. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Hong, C., Kim, H.A., Firestone, G.L., Bjeldanes, L.F. Carcinogenesis (2002) [Pubmed]
  21. Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Liu, S., Abdelrahim, M., Khan, S., Ariazi, E., Jordan, V.C., Safe, S. Biol. Chem. (2006) [Pubmed]
  22. 3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Lake, B.G., Tredger, J.M., Renwick, A.B., Barton, P.T., Price, R.J. Xenobiotica (1998) [Pubmed]
  23. 3,3'-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells. McGuire, K.P., Ngoubilly, N., Neavyn, M., Lanza-Jacoby, S. J. Surg. Res. (2006) [Pubmed]
  24. Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. Riby, J.E., Xue, L., Chatterji, U., Bjeldanes, E.L., Firestone, G.L., Bjeldanes, L.F. Mol. Pharmacol. (2006) [Pubmed]
  25. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. Ge, X., Yannai, S., Rennert, G., Gruener, N., Fares, F.A. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  26. Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice. Anderton, M.J., Manson, M.M., Verschoyle, R., Gescher, A., Steward, W.P., Williams, M.L., Mager, D.E. Drug Metab. Dispos. (2004) [Pubmed]
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