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Chemical Compound Review

Isopropylphenyladenosine     (2R,3S,4R,5R)-2- (hydroxymethyl)-5-[6...

Synonyms: AC1L1RPC, PHENYLISOPROPYLADENOSINE, N6-(Phenylisopropyl)-adenosine, Adenosine, N-(1-methylethyl)-N-phenyl-
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Disease relevance of Isopropylphenyladenosine


High impact information on Isopropylphenyladenosine


Chemical compound and disease context of Isopropylphenyladenosine


Biological context of Isopropylphenyladenosine


Anatomical context of Isopropylphenyladenosine


Associations of Isopropylphenyladenosine with other chemical compounds


Gene context of Isopropylphenyladenosine

  • Second, EEDQ did not alter the inhibition of forskolin-stimulated adenylyl cyclase activity induced by the adenosine A1 receptor agonist phenylisopropyladenosine (PIA).(ABSTRACT TRUNCATED AT 400 WORDS)[22]
  • Although NaCl-free HBSS improved TSH- or Graves' IgG-induced IP and cAMP production in cells with recombinant TSHR; the modulatory action of phenylisopropyladenosine was lost [23].
  • The increase in 3H-thymidine incorporation induced by hexosaminidase B was also inhibited by mannan and PIA [24].
  • By using phenylisopropyladenosine to block IFN-induced lipolysis, we found that in the absence of increased FA flux, INF gamma did not exert a ketogenic effect [25].
  • The ability of GH to modulate the PIA-activated adenosine receptor to stimulate dissociation of heterotrimeric Gi was assessed by measurement of pertussis toxin-catalysed ADP-ribosylation of Gi; GH does not appear to alter the interaction between the activated receptor and Gi [26].

Analytical, diagnostic and therapeutic context of Isopropylphenyladenosine

  • To determine its mechanisms at the level of receptor-G-protein activation, the present studies examined the effect of T62 on A1-stimulated [35S]guanosine-5'-O-(gamma-thio)-triphosphate ([35S]GTPgammaS) binding in brain membranes, and by [35S]GTPgammaS autoradiography using the A1 agonist, phenylisopropyladenosine (PIA), to activate G-proteins [27].


  1. Pertussis toxin reverses adenosine inhibition of neuronal glutamate release. Dolphin, A.C., Prestwich, S.A. Nature (1985) [Pubmed]
  2. Inhibition of adenylate cyclase in rat brain synaptosomal membranes by GTP and phenylisopropyladenosine is enhanced in hypothyroidism. Mazurkiewicz, D., Saggerson, E.D. Biochem. J. (1989) [Pubmed]
  3. Endogenous adenosine reduces depression of cardiac function induced by beta-adrenergic stimulation during low flow perfusion. Fenton, R.A., Galeckas, K.J., Dobson, J.G. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  4. Quinolinic acid neurotoxicity: protection by intracerebral phenylisopropyladenosine (PIA) and potentiation by hypotension. Connick, J.H., Stone, T.W. Neurosci. Lett. (1989) [Pubmed]
  5. Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation. Smith, C.J., Vasta, V., Degerman, E., Belfrage, P., Manganiello, V.C. J. Biol. Chem. (1991) [Pubmed]
  6. Resistance to insulin-stimulated glucose uptake in adipocytes isolated from spontaneously hypertensive rats. Reaven, G.M., Chang, H., Hoffman, B.B., Azhar, S. Diabetes (1989) [Pubmed]
  7. Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Studies on its mechanism of action. Abumrad, N.A., Harmon, C.M., Barnela, U.S., Whitesell, R.R. J. Biol. Chem. (1988) [Pubmed]
  8. Presence of a functional inhibitory GTP-binding regulatory component, Gi, linked to adenylate cyclase in adipocytes of ob/ob mice. Greenberg, A.S., Taylor, S.I., Londos, C. J. Biol. Chem. (1987) [Pubmed]
  9. Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents. Kuroda, M., Honnor, R.C., Cushman, S.W., Londos, C., Simpson, I.A. J. Biol. Chem. (1987) [Pubmed]
  10. Adenosine inhibition of the hormonal response in the Sertoli cell is reversed by pertussis toxin. Monaco, L., DeManno, D.A., Martin, M.W., Conti, M. Endocrinology (1988) [Pubmed]
  11. Changes in the anti-lipolytic action and binding to plasma membranes of N6-L-phenylisopropyladenosine in adipocytes from starved and hypothyroid rats. Chohan, P., Carpenter, C., Saggerson, E.D. Biochem. J. (1984) [Pubmed]
  12. P2-purinergic activation of phosphoinositide turnover is potentiated by A1-receptor stimulation in thyroid cells. Nazarea, M., Okajima, F., Kondo, Y. Eur. J. Pharmacol. (1991) [Pubmed]
  13. Duality in the mastoparan action on glucose transport in rat adipocytes. Omata, W., Suzuki, Y., Kojima, I., Shibata, H. Endocr. J. (2005) [Pubmed]
  14. Influence of development and reduction of fat stores on the antilipolytic alpha 2-adrenoceptor in hamster adipocytes: comparison with adenosine and beta-adrenergic lipolytic responses. Carpene, C., Berlan, M., Lafontan, M. J. Lipid Res. (1983) [Pubmed]
  15. The adenosine Ri agonist, phenylisopropyladenosine, reduces high affinity isoproterenol binding to the beta-adrenergic receptor of rat myocardial membranes. Romano, F.D., Fenton, R.A., Dobson, J.G. Second Messengers Phosphoproteins (1988) [Pubmed]
  16. Diabetes decreases sensitivity of adipocyte lipolysis to inhibition by Gi-linked receptor agonists. Saggerson, D., Orford, M., Chatzipanteli, K., Shepherd, J. Cell. Signal. (1991) [Pubmed]
  17. Regulation of lipolysis by somatotropin: functional alteration of adrenergic and adenosine signaling in bovine adipose tissue. Houseknecht, K.L., Bauman, D.E. J. Endocrinol. (1997) [Pubmed]
  18. Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP. Iyengar, R., Abramowitz, J., Bordelon-Riser, M., Blume, A.J., Birnbaumer, L. J. Biol. Chem. (1980) [Pubmed]
  19. Growth hormone decreases the response to anti-lipolytic agonists and decreases the levels of Gi2 in rat adipocytes. Doris, R., Vernon, R.G., Houslay, M.D., Kilgour, E. Biochem. J. (1994) [Pubmed]
  20. Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism. Kaasik, A., Seppet, E.K., Ohisalo, J.J. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  21. Dietary fat saturation and endurance exercise alter lipolytic sensitivity of adipocytes isolated from Yucatan miniature swine. Meservey, C.M., Carey, G.B. J. Nutr. (1994) [Pubmed]
  22. Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes. Yocca, F.D., Iben, L., Meller, E. Mol. Pharmacol. (1992) [Pubmed]
  23. Receptor cross-talk can optimize assays for autoantibodies to the thyrotropin receptor: effect of phenylisopropyladenosine on adenosine 3',5'-monophosphate and inositol phosphate levels in rat FRTL-5 thyroid cells. Hidaka, A., Okajima, F., Ban, T., Kosugi, S., Kondo, Y., Kohn, L.D. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  24. Dual regulation by cAMP of beta-hexosaminidase-induced mitogenesis in bovine tracheal myocytes. Lew, D.B., Nebigil, C., Malik, K.U. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  25. In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis. Memon, R.A., Feingold, K.R., Moser, A.H., Doerrler, W., Grunfeld, C. Endocrinology (1992) [Pubmed]
  26. Regulation of the GTP-binding protein-based antilipolytic system of sheep adipocytes by growth hormone. Doris, R.A., Kilgour, E., Houslay, M.D., Vernon, R.G. J. Endocrinol. (1998) [Pubmed]
  27. Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain. Childers, S.R., Li, X., Xiao, R., Eisenach, J.C. J. Neurochem. (2005) [Pubmed]
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