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Chemical Compound Review

CHEMBL14658     1,2,3-trichloro-5-(3,4,5...

Synonyms: AG-F-09798, HSDB 3948, PCB 169, AC1L1VCX, LS-44407, ...
 
 
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Disease relevance of PCB 169

 

High impact information on PCB 169

 

Biological context of PCB 169

  • At a longer pretreatment time (48 h), both a non-ortho (I-169 = 3,3',4,4',5,5'-hexachlorobiphenyl) and mono-ortho PCB congener(s) (e.g. I-156) markedly increased the hepatic 3H-uptake (190%), a probable effect of an induction of hepatic binding sites for TCDF [8].
 

Anatomical context of PCB 169

 

Associations of PCB 169 with other chemical compounds

 

Gene context of PCB 169

 

Analytical, diagnostic and therapeutic context of PCB 169

References

  1. Toxicity of 3,4,5,3',4',5'-hexachlorobiphenyl to mink. Aulerich, R.J., Bursian, S.J., Evans, M.G., Hochstein, J.R., Koudele, K.A., Olson, B.A., Napolitano, A.C. Arch. Environ. Contam. Toxicol. (1987) [Pubmed]
  2. Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs). Leece, B., Denomme, M.A., Towner, R., Li, S.M., Safe, S. Journal of toxicology and environmental health. (1985) [Pubmed]
  3. Immunochemical evidence for two 3-methylcholanthrene-inducible forms of cytochrome P-448 in rat liver microsomes using a double-antibody radioimmunoassay procedure. Luster, M.I., Lawson, L.D., Linko, P., Goldstein, J.A. Mol. Pharmacol. (1983) [Pubmed]
  4. Polychlorinated biphenyl-induced immune suppression: castration, but not adrenalectomy or RU 38486 treatment, partially restores the suppressed cytotoxic T lymphocyte response to alloantigen. De Krey, G.K., Baecher-Steppan, L., Deyo, J.A., Smith, B., Kerkvliet, N.I. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  5. Toxicity of polychlorinated biphenyl with special reference to porphyrin metabolism. Sano, S., Kawanishi, S., Seki, Y. Environ. Health Perspect. (1985) [Pubmed]
  6. Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats. Yamamoto, M., Narita, A., Kagohata, M., Shirai, M., Akahori, F., Arishima, K. J. Androl. (2005) [Pubmed]
  7. Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. van Duursen, M.B., Sanderson, J.T., van der Bruggen, M., van der Linden, J., van den Berg, M. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  8. Liver accumulation of 2,3,7,8-tetrachloro-[3H]dibenzofuran in mice: modulation by treatments with polychlorinated biphenyls. Darnerud, P.O., Törnwall, U., Bergman, A., Brandt, I. Chem. Biol. Interact. (1993) [Pubmed]
  9. Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup. Kloepper-Sams, P.J., Park, S.S., Gelboin, H.V., Stegeman, J.J. Arch. Biochem. Biophys. (1987) [Pubmed]
  10. Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450. Sundheimer, D.W., Caveness, M.B., Goldstein, J.A. Arch. Biochem. Biophys. (1983) [Pubmed]
  11. Suppression of allograft immunity by 3,4,5,3',4',5'-hexachlorobiphenyl. I. Effects of exposure on tumor rejection and cytotoxic T cell activity in vivo. Kerkvliet, N.I., Baecher-Steppan, L. Immunopharmacology (1988) [Pubmed]
  12. Suppression of allograft immunity by 3,4,5,3',4',5'-hexachlorobiphenyl. II. Effects of exposure on mixed lymphocyte reactivity and induction of suppressor cell activity in vitro. Kerkvliet, N.I., Baecher-Steppan, L. Immunopharmacology (1988) [Pubmed]
  13. Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons. Kennedy, S.W., Lorenzen, A., Jones, S.P., Hahn, M.E., Stegeman, J.J. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  14. Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Yeowell, H.N., Waxman, D.J., LeBlanc, G.A., Linko, P., Goldstein, J.A. Arch. Biochem. Biophys. (1989) [Pubmed]
  15. Uptake and depuration of PCB 77, PCB 169, and hexachlorobenzene by zebra mussels (Dreissena polymorpha). Brieger, G., Hunter, R.D. Ecotoxicol. Environ. Saf. (1993) [Pubmed]
  16. Polychlorinated biphenyl-induced suppression of cytotoxic T lymphocyte activity: role of prostaglandin-E2. De Krey, G.K., Baecher-Steppan, L., Fowles, J.R., Kerkvliet, N.I. Toxicol. Lett. (1994) [Pubmed]
  17. Effects of two hexachlorobiphenyl isomers on ornithine decarboxylase induction: inhibitory effects correlate with aryl hydrocarbon hydroxylase activity. Potter, C.L., Sipes, I.G., Russell, D.H. Life Sci. (1985) [Pubmed]
  18. Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line. Gribaldo, L., Sacco, M.G., Casati, S., Zucchi, I., Dosanjh, M.K., Catalani, P., Marafante, E. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  19. A comparison of the cytochrome P-450 species induced by mirex and 3,4,5,3',4',5'-hexachlorobiphenyl in hepatic microsomes of the mouse. Peppriell, J. Environmental research. (1980) [Pubmed]
  20. Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus. Kerkvliet, N.I., Baecher-Steppan, L., Smith, B.B., Youngberg, J.A., Henderson, M.C., Buhler, D.R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1990) [Pubmed]
  21. Role of inhibition of uroporphyrinogen decarboxylase in PCB-induced porphyria in mice. Seki, Y., Kawanishi, S., Sano, S. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  22. Coplanar PCBs and the relative contribution of coplanar PCBs, PCDDs, and PCDFs to the total 2,3,7,8-TCDD toxicity equivalents in human serum. Kang, D., Tepper, A., Patterson, D.G. Chemosphere (1997) [Pubmed]
  23. Separation and quantitation of 3,3',4,4'-tetrachlorobiphenyl and 3,3',4,4',5,5'-hexachlorobiphenyl in aroclors using florisil column chromatography and gas-liquid chromatography. Kamops, L.R., Trotter, W.J., Young, S.J., Smith, A.C., Roach, J.A., Page, S.W. Bulletin of environmental contamination and toxicology. (1979) [Pubmed]
 
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