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Chemical Compound Review

CHEMBL14658     1,2,3-trichloro-5-(3,4,5...

Synonyms: AG-F-09798, HSDB 3948, PCB 169, AC1L1VCX, LS-44407, ...
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Disease relevance of PCB 169


High impact information on PCB 169


Biological context of PCB 169

  • At a longer pretreatment time (48 h), both a non-ortho (I-169 = 3,3',4,4',5,5'-hexachlorobiphenyl) and mono-ortho PCB congener(s) (e.g. I-156) markedly increased the hepatic 3H-uptake (190%), a probable effect of an induction of hepatic binding sites for TCDF [8].

Anatomical context of PCB 169


Associations of PCB 169 with other chemical compounds


Gene context of PCB 169


Analytical, diagnostic and therapeutic context of PCB 169


  1. Toxicity of 3,4,5,3',4',5'-hexachlorobiphenyl to mink. Aulerich, R.J., Bursian, S.J., Evans, M.G., Hochstein, J.R., Koudele, K.A., Olson, B.A., Napolitano, A.C. Arch. Environ. Contam. Toxicol. (1987) [Pubmed]
  2. Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs). Leece, B., Denomme, M.A., Towner, R., Li, S.M., Safe, S. Journal of toxicology and environmental health. (1985) [Pubmed]
  3. Immunochemical evidence for two 3-methylcholanthrene-inducible forms of cytochrome P-448 in rat liver microsomes using a double-antibody radioimmunoassay procedure. Luster, M.I., Lawson, L.D., Linko, P., Goldstein, J.A. Mol. Pharmacol. (1983) [Pubmed]
  4. Polychlorinated biphenyl-induced immune suppression: castration, but not adrenalectomy or RU 38486 treatment, partially restores the suppressed cytotoxic T lymphocyte response to alloantigen. De Krey, G.K., Baecher-Steppan, L., Deyo, J.A., Smith, B., Kerkvliet, N.I. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  5. Toxicity of polychlorinated biphenyl with special reference to porphyrin metabolism. Sano, S., Kawanishi, S., Seki, Y. Environ. Health Perspect. (1985) [Pubmed]
  6. Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats. Yamamoto, M., Narita, A., Kagohata, M., Shirai, M., Akahori, F., Arishima, K. J. Androl. (2005) [Pubmed]
  7. Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. van Duursen, M.B., Sanderson, J.T., van der Bruggen, M., van der Linden, J., van den Berg, M. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  8. Liver accumulation of 2,3,7,8-tetrachloro-[3H]dibenzofuran in mice: modulation by treatments with polychlorinated biphenyls. Darnerud, P.O., Törnwall, U., Bergman, A., Brandt, I. Chem. Biol. Interact. (1993) [Pubmed]
  9. Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup. Kloepper-Sams, P.J., Park, S.S., Gelboin, H.V., Stegeman, J.J. Arch. Biochem. Biophys. (1987) [Pubmed]
  10. Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450. Sundheimer, D.W., Caveness, M.B., Goldstein, J.A. Arch. Biochem. Biophys. (1983) [Pubmed]
  11. Suppression of allograft immunity by 3,4,5,3',4',5'-hexachlorobiphenyl. I. Effects of exposure on tumor rejection and cytotoxic T cell activity in vivo. Kerkvliet, N.I., Baecher-Steppan, L. Immunopharmacology (1988) [Pubmed]
  12. Suppression of allograft immunity by 3,4,5,3',4',5'-hexachlorobiphenyl. II. Effects of exposure on mixed lymphocyte reactivity and induction of suppressor cell activity in vitro. Kerkvliet, N.I., Baecher-Steppan, L. Immunopharmacology (1988) [Pubmed]
  13. Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons. Kennedy, S.W., Lorenzen, A., Jones, S.P., Hahn, M.E., Stegeman, J.J. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  14. Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Yeowell, H.N., Waxman, D.J., LeBlanc, G.A., Linko, P., Goldstein, J.A. Arch. Biochem. Biophys. (1989) [Pubmed]
  15. Uptake and depuration of PCB 77, PCB 169, and hexachlorobenzene by zebra mussels (Dreissena polymorpha). Brieger, G., Hunter, R.D. Ecotoxicol. Environ. Saf. (1993) [Pubmed]
  16. Polychlorinated biphenyl-induced suppression of cytotoxic T lymphocyte activity: role of prostaglandin-E2. De Krey, G.K., Baecher-Steppan, L., Fowles, J.R., Kerkvliet, N.I. Toxicol. Lett. (1994) [Pubmed]
  17. Effects of two hexachlorobiphenyl isomers on ornithine decarboxylase induction: inhibitory effects correlate with aryl hydrocarbon hydroxylase activity. Potter, C.L., Sipes, I.G., Russell, D.H. Life Sci. (1985) [Pubmed]
  18. Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line. Gribaldo, L., Sacco, M.G., Casati, S., Zucchi, I., Dosanjh, M.K., Catalani, P., Marafante, E. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  19. A comparison of the cytochrome P-450 species induced by mirex and 3,4,5,3',4',5'-hexachlorobiphenyl in hepatic microsomes of the mouse. Peppriell, J. Environmental research. (1980) [Pubmed]
  20. Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus. Kerkvliet, N.I., Baecher-Steppan, L., Smith, B.B., Youngberg, J.A., Henderson, M.C., Buhler, D.R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1990) [Pubmed]
  21. Role of inhibition of uroporphyrinogen decarboxylase in PCB-induced porphyria in mice. Seki, Y., Kawanishi, S., Sano, S. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  22. Coplanar PCBs and the relative contribution of coplanar PCBs, PCDDs, and PCDFs to the total 2,3,7,8-TCDD toxicity equivalents in human serum. Kang, D., Tepper, A., Patterson, D.G. Chemosphere (1997) [Pubmed]
  23. Separation and quantitation of 3,3',4,4'-tetrachlorobiphenyl and 3,3',4,4',5,5'-hexachlorobiphenyl in aroclors using florisil column chromatography and gas-liquid chromatography. Kamops, L.R., Trotter, W.J., Young, S.J., Smith, A.C., Roach, J.A., Page, S.W. Bulletin of environmental contamination and toxicology. (1979) [Pubmed]
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