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Chemical Compound Review

Alsystin     2-chloro-N-[[4- (trifluoromethoxy)phenyl]ca...

Synonyms: Alsystine, Trifluron, Mascot, Triflumuron, Bay-sir 8514, ...
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Disease relevance of Triflumuron

  • Tests with samples from Saccharomyces cerevisiae mitochondria and Escherichia coli have demonstrated the ability to produce statistically significant identifications, agreeing with two commonly used programs, peptident and mascot, in 86% of samples analyzed [1].
  • Manual analysis and direct spectral comparison reveal that scores from two commonly used search programs (Sequest and Mascot) validate less than half of potentially identifiable MS/MS spectra (class positive) from shotgun analyses of the human erythroleukemia K562 cell line [2].
  • Protein identification MASCOT scores obtained using SID were comparable or better than scores obtained using sustained off-resonance irradiation collision-induced dissociation (SORI-CID), the conventional ion activation technique in FT-ICR MS [3].
  • The toxicity for immatures and eggs, and the sublethal effects described suggest that triflumuron could be an interesting incorporation in integrated pest programs of T. urticae [4].
  • Atrial fibrillation and cardiac resynchronization therapy: the MASCOT study [5].

Psychiatry related information on Triflumuron

  • Scales representing the lost child, the acting out child, and the mascot were highly intercorrelated, but use of the placater role was relatively unrelated to the other roles [6].

High impact information on Triflumuron

  • Using a publicly available expressed sequence tag database and the Mascot search engine, we were able to identify 16 differentially expressed proteins [7].
  • The mass-to-charge ratios and the amino acid sequences of the recovered tryptic peptides were determined by MALDI-TOF/TOF mass spectrometry and the proteins were identified using Mascot software [8].
  • By comparing results of Mascot search against databases of Escherichia coli and genomes of S. flexneri 2a, one S. flexneri-specific protein was identified and one possible gap was found in 2457T genome sequences [9].
  • Mass spectrometry and a Mascot search revealed this protein to be a glycogen debranching enzyme (GDE) [10].
  • Five of these spots were analyzed with MALDI-TOF, but only three showed a significant match in the databases used in bio-informatics analysis (PeptIdent, Mascot, and MS-Fit) [11].

Biological context of Triflumuron

  • For identification, affinity bead-purified plasma protein was subjected to MALDI TOF/TOF analysis followed by Mascot identification of the peptide sequences and a search of the National Center for Biotechnology Information protein database [12].
  • Both Mascot and Spectrum Mill MS Proteomics Workbench software were used to identify the protein composition in these samples and Spectrum Mill was used also to test the possibility of developing a label-free semi-quantitation method based on peptide hits [13].
  • The effects of triflumuron on the mortality, fecundity, and fertility of the two-spotted spider mite, Tetranychus urticae, were evaluated in the laboratory [4].
  • Peptides and proteins identified using Sequest or Mascot are validated with the Trans-Proteomic Pipeline developed at the Institute of Systems Biology and data from the resulting XML file are stored in the database [14].
  • Eight of the up-regulated proteins were identified using MALDI-TOF/MS and MASCOT, and were similar to proteins involved in signal transduction, proteins participating in energy metabolism pathways and proteins involved in stress [15].

Anatomical context of Triflumuron

  • A simulated field experiment with triflumuron, a benzoylphenylurea, on larvae of the house fly Musca domestica in chicken feces [16].
  • Because of its interaction with MAGI-1 and its localization to cell-cell junctions, this novel protein has been given the name MAGI-1-associated coiled-coil tight junction protein (MASCOT) [17].

Associations of Triflumuron with other chemical compounds

  • An on-line pre-concentration method for the analysis of five benzoylureas (diflubenzuron, triflumuron, hexaflumuron, lufenuron and flufenoxuron) in ground water samples was evaluated using two C(18) columns, and fluorescence detection after photochemical induced fluorescence (PIF) post-column derivatization [18].
  • Two chitin synthesis inhibitors (CSIs) viz., triflumuron and hexaflumuron interfere++ with the development of Brugia malayi in Aedes aegypti (a black-eyed Liverpool strain) [19].
  • Data insertion into the relational database of PROTICdb is achieved either by uploading outputs from M??lanie, PDQuest, IM2d, ImageMaster(tm) 2D Platinum v5.0, Progenesis, Sequest, MS-Fit, and Mascot software, or by filling in web forms (experimental design and methods) [20].
  • Phloxine B, triflumuron and T. havanensis fractions were harmless and did not cause any effect on fecundity and fertility with the exception of triflumuron, which reduced considerably the egg hatch [21].
  • The spots were subjected to a combination of tandem mass spectrometry and Mascot and MS BLAST database searches that identified several classes of proteins, including metalloproteinases, serine proteinases, lectins, phospholipases A2, L-amino oxidases, nerve growth factors, vascular endothelial growth factors and cysteine-rich secretory proteins [22].

Gene context of Triflumuron

  • Analysis of the data with the MASCOT database algorithm provided no evidence for the presence of ERbeta in the mitochondria [23].
  • Based on the results from in vitro gel digestion, mass spectrometry and Mascot database search results, we confirmed the presence of BCCP [24].
  • The resultant spectra were processed with "Mascot" search engine to estimate the sequence coverage of the bovine serum albumin (BSA) [25].
  • Our data demonstrated that the serum high abundance 2-DE protein profiles of NPC patients were generally similar to that of the controls, with exception of the ceruloplasmin (CPL) spots (identified by mass spectrometric analysis and MASCOT database search), which showed higher expression [26].

Analytical, diagnostic and therapeutic context of Triflumuron


  1. Genome-based peptide fingerprint scanning. Giddings, M.C., Shah, A.A., Gesteland, R., Moore, B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics. Resing, K.A., Meyer-Arendt, K., Mendoza, A.M., Aveline-Wolf, L.D., Jonscher, K.R., Pierce, K.G., Old, W.M., Cheung, H.T., Russell, S., Wattawa, J.L., Goehle, G.R., Knight, R.D., Ahn, N.G. Anal. Chem. (2004) [Pubmed]
  3. Protein Identification via Surface-Induced Dissociation in an FT-ICR Mass Spectrometer and a Patchwork Sequencing Approach. Fernandez, F.M., Wysocki, V.H., Futrell, J.H., Laskin, J. J. Am. Soc. Mass Spectrom. (2006) [Pubmed]
  4. Effects of triflumuron on the two-spotted spider mite, Tetranychus urticae (Acari: Tetranichydae). Saenz de Cabezón, F.J., Pérez-Moreno, I., Marco, V. Exp. Appl. Acarol. (2002) [Pubmed]
  5. Atrial fibrillation and cardiac resynchronization therapy: the MASCOT study. Padeletti, L., Musilli, N., Porciani, M.C., Colella, A., Di Biase, L., Ricciardi, G., Pieragnoli, P., Michelucci, A., Gensini, G. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. (2004) [Pubmed]
  6. The survival roles of children of alcoholics: their measurement and validity. Devine, C., Braithwaite, V. Addiction (1993) [Pubmed]
  7. Proteomic analysis of somatic embryogenesis in Medicago truncatula. Explant cultures grown under 6-benzylaminopurine and 1-naphthaleneacetic acid treatments. Imin, N., Nizamidin, M., Daniher, D., Nolan, K.E., Rose, R.J., Rolfe, B.G. Plant Physiol. (2005) [Pubmed]
  8. Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis. Curthoys, N.P., Taylor, L., Hoffert, J.D., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  9. A two-dimensional proteome map of Shigella flexneri. Liao, X., Ying, T., Wang, H., Wang, J., Shi, Z., Feng, E., Wei, K., Wang, Y., Zhang, X., Huang, L., Su, G., Huang, P. Electrophoresis (2003) [Pubmed]
  10. Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity. Sakoda, H., Fujishiro, M., Fujio, J., Shojima, N., Ogihara, T., Kushiyama, A., Fukushima, Y., Anai, M., Ono, H., Kikuchi, M., Horike, N., Viana, A.Y., Uchijima, Y., Kurihara, H., Asano, T. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  11. Effect of cryopreservation on sea bass sperm proteins. Zilli, L., Schiavone, R., Zonno, V., Rossano, R., Storelli, C., Vilella, S. Biol. Reprod. (2005) [Pubmed]
  12. Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology. Cheng, A.J., Chen, L.C., Chien, K.Y., Chen, Y.J., Chang, J.T., Wang, H.M., Liao, C.T., Chen, I.H. Clin. Chem. (2005) [Pubmed]
  13. Preliminary approaches for the development of a high-performance liquid chromatography/electrospray ionization tandem mass spectrometry method for the detection and label-free semi-quantitation of the main storage proteins of Lupinus albus in foods. Locati, D., Morandi, S., Zanotti, M., Arnoldi, A. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
  14. YPED: a proteomics database for protein expression analysis. Shifman, M.A., Sun, K., Colangelo, C.M., Cheung, K.H., Miller, P., Williams, K. AMIA ... Annual Symposium proceedings [electronic resource] / AMIA Symposium. AMIA Symposium. (2005) [Pubmed]
  15. Protein expression analysis of Halobacillus dabanensis D-8T subjected to salt shock. Feng, d.e. .Q., Zhang, B., Lu, W.D., Yang, S.S. J. Microbiol. (2006) [Pubmed]
  16. A simulated field experiment with triflumuron, a benzoylphenylurea, on larvae of the house fly Musca domestica in chicken feces. Fukase, T., Kamon, M., Itagaki, H. Nippon Juigaku Zasshi (1988) [Pubmed]
  17. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Patrie, K.M. Biochim. Biophys. Acta (2005) [Pubmed]
  18. Determination of benzoylureas in ground water samples by fully automated on-line pre-concentration and liquid chromatography-fluorescence detection. Gil García, M.D., Martínez Galera, M., Barranco Martínez, D., Gisbert Gallego, J. Journal of chromatography. A. (2006) [Pubmed]
  19. The effect of chitin synthesis inhibitors on the development of Brugia malayi in Aedes aegypti. Mohapatra, R., Ranjit, M.R., Dash, A.P. J. Helminthol. (1996) [Pubmed]
  20. The PROTICdb Database for 2-DE Proteomics. Langella, O., Zivy, M., Joets, J. Methods Mol. Biol. (2006) [Pubmed]
  21. Topical toxicity of two acetonic fractions of Trichilia havanensis Jacq. and four insecticides to larvae and adults of Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae). Huerta, A., Medina, P., Smagghe, G., Castañera, P., Viñuela, E. Communications in agricultural and applied biological sciences. (2003) [Pubmed]
  22. Ontogenetic variations in the venom proteome of the Amazonian snake Bothrops atrox. Guércio, R.A., Shevchenko, A., Shevchenko, A., López-Lozano, J.L., Paba, J., Sousa, M.V., Ricart, C.A. Proteome science [electronic resource]. (2006) [Pubmed]
  23. False positives in MALDI-TOF detection of ERbeta in mitochondria. Schwend, T., Gustafsson, J.A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  24. Biotin carboxyl carrier protein co-purifies as a contaminant in core-streptavidin preparations. Wang, W.W., Das, D., Suresh, M.R. Mol. Biotechnol. (2005) [Pubmed]
  25. Improvement of automatic in-gel digestion by in situ alkylation of proteins. Yokono, T., Mineki, R., Taka, H., Kotaniguchi, H., Murayama, K. Journal of biomolecular techniques : JBT. (2003) [Pubmed]
  26. Patients with nasopharyngeal carcinoma demonstrate enhanced serum and tissue ceruloplasmin expression. Doustjalali, S.R., Yusof, R., Govindasamy, G.K., Bustam, A.Z., Pillay, B., Hashim, O.H. J. Med. Invest. (2006) [Pubmed]
  27. Identification and phenotypic characterization of Sphingomonas wittichii strain RW1 by peptide mass fingerprinting using matrix-assisted laser desorption ionization-time of flight mass spectrometry. Halden, R.U., Colquhoun, D.R., Wisniewski, E.S. Appl. Environ. Microbiol. (2005) [Pubmed]
  28. Peptide sequence tags for fast database search in mass-spectrometry. Frank, A., Tanner, S., Bafna, V., Pevzner, P. J. Proteome Res. (2005) [Pubmed]
  29. Identification of a new protein from silkworm pupas by biological mass spectrometry. Jiang, L., Liu, Q., Hu, D., Jiang, L., Xu, H., Wang, H. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2005) [Pubmed]
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