Disease relevance of Cascade

• Targeting Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in the Mutant (V600E) B-Raf Signaling Cascade Effectively Inhibits Melanoma Lung Metastases [1].
• Fluorescence resonance energy transfer experiments indicated that mAbs CS6 and CS8 efficiently compete with Cascade Blue-labeled mAb 44.1 (a previously characterized, p22(phox)-specific mAb) for binding to Cyt b, supporting phage display results suggesting that all three Abs recognize a common region of p22(phox) [2].
• Transcriptional Regulatory Cascade for Elastase Production in Vibrio vulnificus: LuxO ACTIVATES luxT EXPRESSION AND LuxT REPRESSES smcR EXPRESSION [3].
• Pseudomonas Lipopolysaccharide Accelerates Wound Repair via Activation of a Novel Epithelial Cell Signaling Cascade [4].
• Asynchronous Progression through the Lytic Cascade and Variations in Intracellular Viral Loads Revealed by High-Throughput Single-Cell Analysis of Kaposi's Sarcoma-Associated Herpesvirus Infection [5].

Psychiatry related information on Cascade

• In Alzheimer's disease (AD), the 'Cascade hypothesis' proposes that the formation of paired helical filaments (PHF) may be casually linked to the deposition of beta/A4 protein [6].

High impact information on Cascade

• Dye transfer studies using the gap junction permeant tracer Cascade Blue demonstrated a disruption to the intercellular coupling for all four of the mutant proteins [7].
• Role of the CCAAT/Enhancer-binding Protein NFATc2 Transcription Factor Cascade in the Induction of Secretory Phospholipase A2 [8].
• RESULTS: In confluent fibroblast or myofibroblast cultures, the scrape-loaded dextran probe remained within wounded cells, whereas the Lucifer yellow or Cascade blue dye diffused into adjacent intact cells [9].
• The chemical-kinetic analysis uses three different pore states (P) in the reaction cascade (C <==> P1 <==> P2 <==> P3), to model the sigmoid kinetics of pore formation as well as the biphasic pore resealing [10].
• In conclusion, we demonstrate the production of C3 by microvascular endothelium of glomerular origin and its stimulation by TNF-alpha [11].

Chemical compound and disease context of Cascade

• "Psoriasis as a possible defect of the adenyl cyclase-cyclic AMP Cascade" by Voorhees and Duell, October 1971. Commentary: Cyclic adenosine monophosphate regulation of normal and psoriatic epidermis [12].

Biological context of Cascade

• To test whether mutations within the CD95 cDNA sequence caused resistance to apoptosis in H-RS cells, sequence analysis of CD95 cDNA obtained from L1236 and L428 was performed [13].
• Metal-Free Entry to Phosphonylated Isoindoles by a Cascade of 5-exo-dig Cyclization, a [1,3]-Alkyl Shift, and Aromatization under Microwave Heating [14].
• For further characterization of the mechanisms leading to prevention of apoptotic cell death in H-RS cells, it is necessary to determine impairments within the signaling cascade following CD95 activation [15].
• Transepithelial electrical resistance and paracellular fluxes of 10 kD Cascade blue conjugate dextran were measured [16].
• RESULT(S): On the basis of the direct in situ mixing of the colors of fluorochromes (FITC, TRITC, Cascade Blue) that were incorporated in sequential PRINS reactions, this method allows rapid and efficient labeling of three or four individual chromosomes [17].

Anatomical context of Cascade

• RESULTS: Expression of CD95 on the cell surface was detected in both cell lines [15].
• MATERIALS AND METHODS: Two B-cellular H-RS cell lines (L1236 and L428) were used to test for the expression of CD95 by flow cytometry and for the induction of apoptosis after incubation with CD95L obtained from retrovirally transduced murine myoblasts [13].
• Central to the activation of microglia is the membrane receptor CD40, which is the target of costimulators such as interferon-gamma (IFNgamma) [18].
• This is the first study to demonstrate the appearance of the Fibonacci Cascade within the distribution of coronary artery lesions in the human heart [19].
• A series of poly(alkyl methacrylate) coatings was therefore analysed with regard to the human immune complement (IC) activation and the surface associated blood plasma coagulation cascade (CC) properties [20].

Associations of Cascade with other chemical compounds

• Water-Triggered and Gold(I)-Catalyzed Cascade Addition/Cyclization of Terminal Alkynes with ortho-Alkynylaryl Aldehyde [21].
• METHODS: Cascade impaction methods with high-performance liquid chromatography were used to evaluate the fine particle mass (FPM) of albuterol administered without and with the use of 2 commercially available VHCs [22].
• In newborns thought to have jaundice, the nurses estimated bilirubin levels, documented the extent of caudal progression of the jaundice, and determined the Ingram (Cascade Health Care Products, Salem, Ore) icterometer readings from the newborns' noses [23].
• A liquid chromatography (LC) method for the quantitative determination of three benzoylurea insecticide residues (diflubenzuron, flufenoxuron and hexaflumuron) in citrus fruits is described [24].
• Particle size analysis of the four products using the Andersen Cascade Impactor Mark II showed that the distribution profiles were not identical [25].

Gene context of Cascade

• This is the first individual with biallelic MSH6 mutations reported with either medulloblastoma or acute myelocytic leukemia.Management Cascade genetic testing and colonoscopic screening for colorectal carcinoma has been offered to relatives carrying one mutation [26].
• Nitric Oxide-GAPDH-Siah: A Novel Cell Death Cascade [27].
• DESIGN: Cascade screening was performed for Australian families that had been identified as having the myocilin Gln368STOP mutation [28].
• Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the predominant mechanism thought to be responsible for the disease [29].
• The analytical signal was derived from fluorescence energy transfer between Cascade Blue and the heme group of myoglobin [30].

Analytical, diagnostic and therapeutic context of Cascade

• Production of the C3 protein was demonstrated by radiolabeling and immunoprecipitation, and this also was stimulated by TNF-alpha [11].
• Sequence analysis of CD95 cDNA obtained from these H-RS cell lines was performed [13].
• Therefore, two B-cellular H-RS cell lines (L1236 and L428) were used to test for the expression of CD95 by flow cytometry and for the induction of apoptosis after incubation with CD95L obtained from retrovirally transduced murine myoblasts [15].
• OBJECTIVE: To compare the temperature and humidification output of one heated humidifier system (Bennett Cascade 2 Humidifier) and two heat and moisture exchangers (Pall Ultipor, BB 50, and Humid-Vent Filter) in intensive care unit (ICU) patients submitted to a minute ventilation of > 10 L/min [31].
• Analysis of the pesticide flufenoxuron in apples and kiwifruit by high-performance liquid chromatography [32].

References