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Chemical Compound Review

Fialurdine     1-[(2R,3S,4R,5R)-3-fluoro-4- hydroxy-5...

Synonyms: FIALURIDINE, FIAU, SureCN3189, CHEMBL271475, DRG-0098, ...
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Disease relevance of FIALURIDINE


High impact information on FIALURIDINE


Chemical compound and disease context of FIALURIDINE


Biological context of FIALURIDINE


Anatomical context of FIALURIDINE


Gene context of FIALURIDINE


Analytical, diagnostic and therapeutic context of FIALURIDINE


  1. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. McKenzie, R., Fried, M.W., Sallie, R., Conjeevaram, H., Di Bisceglie, A.M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C. N. Engl. J. Med. (1995) [Pubmed]
  2. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Lewis, W., Levine, E.S., Griniuviene, B., Tankersley, K.O., Colacino, J.M., Sommadossi, J.P., Watanabe, K.A., Perrino, F.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. Lee, E.W., Lai, Y., Zhang, H., Unadkat, J.D. J. Biol. Chem. (2006) [Pubmed]
  4. Priming of duck hepatitis B virus reverse transcription in vitro: premature termination of primer DNA induced by the 5'-triphosphate of fialuridine. Staschke, K.A., Colacino, J.M. J. Virol. (1994) [Pubmed]
  5. Current pharmacological approaches to the therapy of varicella zoster virus infections: a guide to treatment. Snoeck, R., Andrei, G., De Clercq, E. Drugs (1999) [Pubmed]
  6. Lactic acidosis associated with stavudine administration: a report of five cases. Mokrzycki, M.H., Harris, C., May, H., Laut, J., Palmisano, J. Clin. Infect. Dis. (2000) [Pubmed]
  7. Sensitive and specific radioimmunoassay for fialuridine: initial assessment of pharmacokinetics after single oral doses to healthy volunteers. Bowsher, R.R., Compton, J.A., Kirkwood, J.A., Place, G.D., Jones, C.D., Mabry, T.E., Hyslop, D.L., Hatcher, B.L., DeSante, K.A. Antimicrob. Agents Chemother. (1994) [Pubmed]
  8. Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism? Moyle, G. Drug safety : an international journal of medical toxicology and drug experience. (2000) [Pubmed]
  9. Mitochondrial injury. Lessons from the fialuridine trial. Honkoop, P., Scholte, H.R., de Man, R.A., Schalm, S.W. Drug safety : an international journal of medical toxicology and drug experience. (1997) [Pubmed]
  10. Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax). Lewis, W., Griniuviene, B., Tankersley, K.O., Levine, E.S., Montione, R., Engelman, L., de Courten-Myers, G., Ascenzi, M.A., Hornbuckle, W.E., Gerin, J.L., Tennant, B.C. Lab. Invest. (1997) [Pubmed]
  11. Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2. Chen, M.S., Amico, L.A., Speelman, D.J. Antimicrob. Agents Chemother. (1984) [Pubmed]
  12. Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration. Richardson, F.C., Engelhardt, J.A., Bowsher, R.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  13. Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate. Lewis, W., Meyer, R.R., Simpson, J.F., Colacino, J.M., Perrino, F.W. Biochemistry (1994) [Pubmed]
  14. Falsely low calcium measurements after high volume plasma exchange in a patient with liver failure. Miller, J.P., Mintz, P.D. Transfusion science. (1994) [Pubmed]
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