Disease relevance of Marmota

• Nitrite and nitrosamine synthesis by hepatocytes isolated from normal woodchucks (Marmota monax) and woodchucks chronically infected with woodchuck hepatitis virus [1].
• Persistent infection of the eastern woodchuck (Marmota monax) with the woodchuck hepatitis virus (WHV) produces disease sequelae similar to those observed in humans with persistent hepatitis B virus infection, including hepatocellular carcinoma (HCC) [2].
• Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris) [3].
• Interrelationships between body weight, food consumption and plasma thyroid hormone concentration cycles in the woodchuck, Marmota monax [4].

High impact information on Marmota

• Integrations of woodchuck hepatitis virus (WHV) DNA and rearrangements of the N-myc 2 gene have been detected frequently in hepatocellular carcinoma (HCC) of Eastern woodchucks (Marmota monax) chronically infected with WHV [5].
• The subgenera Marmota and Petromarmota, recently proposed on the basis of mitochondrial cytochrome b sequence, receive support from mandible morphology [6].
• Melatonin profile in marmots: the influence of catecholamines, hibernation, and light [7].
• Seasonal changes in serum thyroid hormone binding proteins in the woodchuck (Marmota monax) [8].
• Changes in vaginal cytology were assessed and correlated with temporal changes in circulating concentrations of progesterone (P) and estradiol-17 beta (E2) during the breeding season (February to March) in a seasonally breeding rodent, the woodchuck (Marmota monax) [9].

Chemical compound and disease context of Marmota

• Adult woodchucks (Marmota monax) chronically infected with woodchuck hepatitis virus (WHV) were treated orally with lamivudine (15 mg/kg per day) for 57 weeks [10].

Biological context of Marmota

• Molecular cloning and characterization of major histocompatibility complex class I cDNAs from woodchuck (Marmota monax) [11].
• Seasonal variations in circulating levels of progesterone and estradiol in unmated adult female woodchucks (Marmota monax) in captivity [12].
• Body temperature (Tb) of socially hibernating alpine marmots, a pair and two family groups, was monitored continuously from October to March with implanted temperature-sensitive radiotransmitters [13].
• The purpose of this study was to evaluate the pharmacokinetics of cyclosporine (Cy) in woodchucks (Marmota monax) and Pekin ducks [14].
• Circannual changes in free thyroxine, prolactin, testes, and relative food intake in woodchucks, Marmota monax [15].

Anatomical context of Marmota

• These results provide indirect evidence that the pancreatic A and B cells of hibernating marmots continue to function in order to help regulate plasma glucose concentration [16].
• Real-time polymerase chain reaction assays for leukocyte CD and cytokine mRNAs of the Eastern woodchuck (Marmota monax) [17].
• Blood samples were obtained in the field by femoral vein puncture in bushy-tailed woodrats (Neotoma cinerea) and yellow-bellied marmots (Marmota flaviventris) that had been injected intramuscularly with ketamine hydrochloride [18].

Associations of Marmota with chemical compounds

• Circannual changes in serum testosterone concentrations of adult and yearling woodchucks (Marmota monax) [19].
• Lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, effectively reduced WHV-viremia in chronically infected carrier woodchucks (Marmota monax) by daily per os treatment [20].
• In this study, marmots fed a diet high in alpha-linolenic acid, with normal linoleic acid levels, had significantly (p < 0.05) more alpha-18:3 in their WAT and plasma unesterified fatty acids after 4 months than did marmots fed a control diet [21].
• Ventilation was measured across a range of O2 consumption rates in four sciurid rodents: Tamias minimus (47 g), Spermophilus lateralis (189 g), S. beecheyi (531 g), and Marmota flaviventris juveniles (1054 g) and adults (2989 g) [22].
• The effects of pentobarbital (30 mg/kg), urethan (2 g/kg), chloralose/urethan (50 mg/kg, 500 mg/kg), and thiobutabarbital (Inactin, 100 mg/kg) on the mean arterial pressure (BP) and heart period (HP) of Marmota flaviventris were examined [23].

Gene context of Marmota

• Molecular characterization of CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) of woodchuck (Marmota monax) [24].
• These results suggest that the genes for LPL and HSL are regulated seasonally to control the adipose mass depot in marmots [25].
• Woodchucks (Marmota monax) were infected with LAC virus by needle and syringe [26].
• Plasma atrial natriuretic factor (ANF) was measured in 16 marmots at various times of the year [27].
• When glucose is administered to euthermic or hibernating marmots, plasma insulin concentrations rise and glucagon levels fall [16].

References