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Chemical Compound Review

Fenticonazol     1-[2-(2,4-dichlorophenyl)-2- [(4...

Synonyms: FENTICONAZOLE, Fenticonazolum, SureCN147157, CHEMBL1651990, AC1L1BNP, ...
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Disease relevance of Lomexin


High impact information on Lomexin


Chemical compound and disease context of Lomexin


Biological context of Lomexin


Anatomical context of Lomexin

  • When instilled into the conjunctival sac in rabbits fenticonazole led to a slight reddening of the mucosa in only one animal [14].

Associations of Lomexin with other chemical compounds

  • The activity of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) compared with those of reference drugs, was tested in vitro on various bacteria and fungi [15].
  • Various tests were used in order to ascertain any irritating, sensitising or toxic potential of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) when applied to the skin or to mucous membranes in gel or cream formulation [14].

Analytical, diagnostic and therapeutic context of Lomexin


  1. Comparison of the in vitro activities of fenticonazole, other imidazoles, metronidazole, and tetracycline against organisms associated with bacterial vaginosis and skin infections. Jones, B.M., Geary, I., Lee, M.E., Duerden, B.I. Antimicrob. Agents Chemother. (1989) [Pubmed]
  2. Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets. Lawrence, A.G., Houang, E.T., Hiscock, E., Wells, M.B., Colli, E., Scatigna, M. Current medical research and opinion. (1990) [Pubmed]
  3. Clinical experience with fenticonazole 2% formulation in the treatment of dermatomycoses and pityriasis versicolor. Aste, N., Pau, M., Zucca, M., Biggio, P. International journal of clinical pharmacology research. (1987) [Pubmed]
  4. Double-blind study with fenticonazole or bifonazole lotions in pityriasis versicolor. Aste, N., Pau, M., Cordaro, C.I., Biggio, P. International journal of clinical pharmacology research. (1988) [Pubmed]
  5. Recurrent tinea pedis: a double blind study on the prophylactic use of fenticonazole powder. Albanese, G., Di Cintio, R., Giorgetti, P., Galbiati, G., Ciampini, M. Mycoses (1992) [Pubmed]
  6. Evaluation of skin irritation and contact sensitizing potential of fenticonazole. Pigatto, P., Colli, E., Scatigna, M., Finzi, A. Arzneimittel-Forschung. (1990) [Pubmed]
  7. Effect of fenticonazole spray in cutaneous mycosis: a double-blind clinical trial versus cyclopyroxolamine spray. Altmeyer, P., Nolting, S., Kuhlwein, A., Colli, E., Scatigna, M. J. Int. Med. Res. (1990) [Pubmed]
  8. Ultrastructural findings of Candida albicans blastoconidia submitted to the action of fenticonazole. Costa, A., Veronese, M., Ruggeri, P., Valenti, A. Arzneimittel-Forschung. (1989) [Pubmed]
  9. Antifungal activity of fenticonazole in experimental dermatomycosis and candidiasis. Veronese, M., Barzaghi, D., Bertoncini, A. Arzneimittel-Forschung. (1981) [Pubmed]
  10. Treatment of dermatomycoses with topical fenticonazole and econazole. Kokoschka, E.M., Niebauer, G., Mounari, M., Monici Preti, P. Mykosen. (1986) [Pubmed]
  11. The Salmonella mutagenicity assay on fenticonazole, a new antifungal imidazole derivative. Veronese, M., Barzaghi, D., Bertoncini, A., Zadro, M. Arzneimittel-Forschung. (1981) [Pubmed]
  12. Efficacy and tolerance of fenticonazole versus miconazole cream. Clerico, R., Ribuffo, A. International journal of clinical pharmacology research. (1987) [Pubmed]
  13. Mutagenicity studies on fenticonazole, a new antifungal imidazole derivative. Veronese, M., Barzaghi, D., Bertoncini, A., Zadro, M. Arzneimittel-Forschung. (1981) [Pubmed]
  14. Irritation and toxicity studies with fenticonazole applied topically to the skin and mucous membranes. Graziani, G., Cazzulani, P. Arzneimittel-Forschung. (1981) [Pubmed]
  15. Fenticonazole, a new imidazole derivative with antibacterial and antifungal activity. In vitro study. Veronese, M., Salvaterra, M., Barzaghi, D. Arzneimittel-Forschung. (1981) [Pubmed]
  16. The development and validation of a high performance liquid chromatography (HPLC)/tandem mass spectrometry assay for fenticonazole in human plasma and comparison with an HPLC-UV method. Speed, W., Long, J.M., Simmonds, R.J., Enos, T.A. Rapid Commun. Mass Spectrom. (1995) [Pubmed]
  17. Chiral discrimination by HPLC and CE and antifungal activity of racemic fenticonazole and its enantiomers. Quaglia, M.G., Donati, E., Desideri, N., Fanali, S., D'auria, F.D., Tecca, M. Chirality. (2002) [Pubmed]
  18. Fenticonazole tissue levels after the application of 3 different dosage forms of vaginal ovules. Gorlero, F., Sartani, A., Cordaro, C.I., Bertin, D., Reschiotto, C., De Cecco, L. International journal of clinical pharmacology, therapy, and toxicology. (1988) [Pubmed]
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