Disease relevance of Monofluoressigsaures natrium

• A benchmark dose analysis for sodium monofluoroacetate (1080) using dichotomous toxicity data [1].
• Male rats were used to study the inorganic (ionic) and organic fluoride concentrations in plasma, liver, kidneys and stomach content after oral doses of 0, 2.2, 3.5, 4.0, 5.0 and 7.0 mg sodium monofluoroacetate (SMFA, Compound 1080)/kg body weight [2].
• Hypotension is one of the most important predictors of mortality in sodium monofluoroacetate (SMFA) intoxication [3].
• The signs and symptoms induced in the animals by the crude extract and water-soluble fraction were the same as induced by SMFA and included tonic seizures and other actions on the CNS [4].
• A rabbiter who was repeatedly exposed to sodium monofluoroacetate (compound 1080) developed renal failure and evidence of other organ damage [5].

High impact information on Monofluoressigsaures natrium

• Transferrin endocytosis was less susceptible to the effects of metabolic inhibitors such as sodium fluoroacetate, potassium cyanide, 2,4, dinitrophenol or carbonylcyanide M-chlorophenyl hydrazone (CCCP) than was iron uptake [6].
• A 90-day toxicological evaluation of Compound 1080 (sodium monofluoroacetate) in Sprague-Dawley rats [7].
• The positive inotropic action of sodium fluoroacetate on guinea-pig ventricular myocardium [8].
• This paper presents the development of a tolerable daily intake (TDI) for sodium monofluoroacetate (1080) using the quantal myocardial and testicular toxicity end points derived from the traditional NOAEL and newer benchmark dose (BMD) methods [9].
• Ecotoxicological evaluation of sodium fluoroacetate on aquatic organisms and investigation of the effects on two fish cell lines [10].

Chemical compound and disease context of Monofluoressigsaures natrium

• The toxicity of Compound 1080 (sodium fluoroacetate) livestock protection collars (LPCs) to sheep was investigated [11].
• Acute toxicity of benzene, trichloroethylene, mercuric chloride, cadmium chloride, fratol, methylparathion and dieldrin increased markedly at a low temperature of 8 degrees C, as well as at a high temperature of 38 degrees C. Acute toxicity of toluene, copper sulfate and chromium trioxide was only enhanced at a high temperature of 38 degrees C [12].
• Administration of 100 mg sodium fluoroacetate (compound 1080) per kilogram body weight to T. rugosa resulted in a 3.4-fold increase in plasma citrate levels 48 h after dosing while administration of 3 mg sodium fluoroacetate per kilogram body weight to R. norvegicus produced a fivefold increase in plasma citrate levels within 4 h [13].
• Levels of citrate in kidneys and livers of rats with normal glutathione levels increased 6.8 and 1.7-fold respectively 2 h after dosing with 1.5 mg of compound 1080 (= 95% sodium fluoroacetate) per kilogram body weight [14].

Biological context of Monofluoressigsaures natrium

• Sodium fluoroacetate (SFAC) or Compound 1080 is a potent rodenticide, largely used after 1946 for rodent and home pest control [15].
• The effect of monoacetin and calcium chloride on acid-base balance and survival in experimental sodium fluoroacetate poisoning [16].
• Administration of 300 mg sodium fluoroacetate per kilogram body weight reduced the oxygen consumption of the skink by between 2.5 and 11% while in the rat, 2 mg sodium fluoroacetate per kilogram body weight reduced oxygen consumption by between 28 and 57% [13].

Anatomical context of Monofluoressigsaures natrium

• Application of the approach to determination of FAA in blood plasma and organ tissues of animals poisoned with sodium fluoroacetate reveals substantial differences between the dynamics of FAA accumulation and clearance in rabbits and rats [17].
• A similar inhibitory effect upon DNA synthesis was also found in cells cultured in the abdominal cavity of host mice injected intraperitoneally with 5 mg./kg. of sodium fluoroacetate [18].

Associations of Monofluoressigsaures natrium with other chemical compounds

• Tissue fluoroacetate residues in prairie dogs dosed with low-level sodium monofluoroacetate [19].

Gene context of Monofluoressigsaures natrium

• The detection limit for compound 1080 using the described analytical procedure, was 15 micrograms/kg with PID and 100 micrograms/kg with FID [20].
• Serotonergic and cholecystokinin antagonists change patterns of response in rats (Rattus norvegicus) to oral sodium monofluoroacetate [21].

Analytical, diagnostic and therapeutic context of Monofluoressigsaures natrium

• METHODS: A retrospective study of 38 consecutive cases of sodium monofluoroacetate poisoning at the National Cheng Kung. University Hospital, 1988-1993, to analyze the clinical findings and to predict mortality [22].
• Determination of sodium monofluoroacetate (compound 1080) in tissues and baits as its benzyl ester by reaction-capillary gas chromatography [20].
• Inorganic and organic fluoride concentrations in tissues after the oral administration of sodium monofluoroacetate (Compound 1080) to rats [2].
• A reaction-capillary gas-chromatographic procedure using photo-ionization (PID) or flame-ionization (FID) detection was developed for the determination of sodium monofluoroacetate (compound 1080), a pesticide, in tissues and baits [20].
• Determination of sodium fluoroacetate (compound 1080) in poison baits by HPLC [23].

References