The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

NAAG     2-[(2-acetamido-3-carboxy...

Synonyms: N-Ac-D-E, spaglumic acid, CHEMBL64966, AG-J-18190, A5930_SIGMA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N-Acetyl-aspartyl-glutamate


High impact information on N-Acetyl-aspartyl-glutamate

  • We describe here a new strategy for the treatment of stroke, through the inhibition of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase), an enzyme responsible for the hydrolysis of the neuropeptide NAAG (N-acetyl-aspartyl-glutamate) to N-acetyl-aspartate and glutamate [5].
  • GCP II is believed to mediate the hydrolysis of N-acetyl-aspartyl-glutamate (NAAG) to glutamate and N-acetyl-aspartate, and inhibition of NAAG peptidase activity (by GCP II and other peptidases) is neuroprotective [6].
  • Furthermore, we show that two mGluR3 agonists, the direct agonist (2R,4R)-4-aminopyrrolidine-2, 4-dicarboxylate (APDC) and N-acetyl-aspartyl-glutamate (NAAG) provide protection to neurons exposed to high glucose conditions, consistent with the concept that 2-PMPA neuroprotection is mediated by increased NAAG activity [7].
  • These findings provide a possible mechanism for NAAG inactivation subsequent to its release from nerve endings [8].
  • Separate quantification of the two tNAA components yielded no significant difference in NAA (N-acetyl-aspartate), while the concentration of NAAG (N-acetyl-aspartyl-glutamate) was slightly-but significantly-elevated in MS patients [9].

Biological context of N-Acetyl-aspartyl-glutamate


Anatomical context of N-Acetyl-aspartyl-glutamate


Associations of N-Acetyl-aspartyl-glutamate with other chemical compounds


Gene context of N-Acetyl-aspartyl-glutamate


Analytical, diagnostic and therapeutic context of N-Acetyl-aspartyl-glutamate


  1. Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia. Van Hemelrijck, A., Hachimi-Idrissi, S., Sarre, S., Ebinger, G., Michotte, Y. J. Neurochem. (2005) [Pubmed]
  2. The protective effect of N-acetyl-aspartyl-glutamate (NAAGA) against nasal obstruction provoked by antigen in allergic rhinitis. Magyar, P., Györi, Z., Márk, Z., Hutás, I. Allergy (1993) [Pubmed]
  3. Altered metabolism of excitatory amino acids, N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis. Plaitakis, A., Constantakakis, E. Brain Res. Bull. (1993) [Pubmed]
  4. Effects of lodoxamide (LOD), disodium cromoglycate (DSCG) and N-acetyl-aspartyl-glutamate sodium salt (NAAGA) on ocular active anaphylaxis. Goldschmidt, P., Luyckx, J. Allergie et immunologie. (1996) [Pubmed]
  5. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Slusher, B.S., Vornov, J.J., Thomas, A.G., Hurn, P.D., Harukuni, I., Bhardwaj, A., Traystman, R.J., Robinson, M.B., Britton, P., Lu, X.C., Tortella, F.C., Wozniak, K.M., Yudkoff, M., Potter, B.M., Jackson, P.F. Nat. Med. (1999) [Pubmed]
  6. Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury. Bacich, D.J., Wozniak, K.M., Lu, X.C., O'Keefe, D.S., Callizot, N., Heston, W.D., Slusher, B.S. J. Neurochem. (2005) [Pubmed]
  7. Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3. Berent-Spillson, A., Robinson, A.M., Golovoy, D., Slusher, B., Rojas, C., Russell, J.W. J. Neurochem. (2004) [Pubmed]
  8. Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. Blakely, R.D., Ory-Lavollée, L., Thompson, R.C., Coyle, J.T. J. Neurochem. (1986) [Pubmed]
  9. MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter. Vrenken, H., Barkhof, F., Uitdehaag, B.M., Castelijns, J.A., Polman, C.H., Pouwels, P.J. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2005) [Pubmed]
  10. Ontogenesis of N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in rat brain. Koller, K.J., Coyle, J.T. Brain Res. (1984) [Pubmed]
  11. Effect of an inhaled mast cell stabiliser, N-acetyl-aspartyl-glutamate (Zy15109) on allergen-induced immediate bronchoconstriction. Lai, C.K., Gregory, J., Holgate, S.T. British journal of clinical pharmacology. (1989) [Pubmed]
  12. Specific role of N-acetyl-aspartyl-glutamate in the in vivo regulation of dopamine release from dendrites and nerve terminals of nigrostriatal dopaminergic neurons in the cat. Galli, T., Godeheu, G., Artaud, F., Desce, J.M., Pittaluga, A., Barbeito, L., Glowsinki, J., Chéramy, A. Neuroscience (1991) [Pubmed]
  13. Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. Chen, S.R., Wozniak, K.M., Slusher, B.S., Pan, H.L. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  14. Medial septal neurons containing N-acetyl-aspartyl-glutamate-like immunoreactivity project to the hippocampal formation in the rat. Senut, M.C., De Bilbao, F., Lamour, Y. Neurosci. Lett. (1990) [Pubmed]
  15. The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [3H]NAAG catabolism in vivo. Stauch, B.L., Robinson, M.B., Forloni, G., Tsai, G., Coyle, J.T. Neurosci. Lett. (1989) [Pubmed]
  16. Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen. Ghosh, A., Heston, W.D. Prostate (2003) [Pubmed]
  17. Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test. Yamamoto, T., Nozaki-Taguchi, N., Sakashita, Y., Inagaki, T. Neuroscience (2001) [Pubmed]
  18. Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Blakely, R.D., Ory-Lavollée, L., Grzanna, R., Koller, K.J., Coyle, J.T. Brain Res. (1987) [Pubmed]
  19. Neurotensin, N-acetyl-aspartylglutamate and beta-endorphin modulate [3H]dopamine release from guinea pig nucleus accumbens, prefrontal cortex and caudate-putamen. Weatherspoon, J.K., Frank, A.R., Werling, L.L. Neuropeptides (1996) [Pubmed]
  20. N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. Koller, K.J., Zaczek, R., Coyle, J.T. J. Neurochem. (1984) [Pubmed]
  21. A preliminary evaluation of the effect of N-acetyl-aspartyl-glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology. Ghaem, A. Allergy (1987) [Pubmed]
  22. Regional brain levels of N-acetyl-aspartyl-glutamate: the effect of kindled seizures. Meyerhoff, J.L., Koller, K.J., Walczak, D.D., Coyle, J.T. Brain Res. (1985) [Pubmed]
  23. Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay. Guarda, A.S., Robinson, M.B., Ory-Lavollée, L., Forloni, G.L., Blakely, R.D., Coyle, J.T. Brain Res. (1988) [Pubmed]
WikiGenes - Universities