Disease relevance of DEHYDROABIETIC ACID

• Pseudomonas abietaniphila BKME-9 is able to degrade dehydroabietic acid (DhA) via ring hydroxylation by a novel dioxygenase [1].
• Substrate binding assays of P450dit expressed in Escherichia coli revealed that DhA binds to the enzyme and yields a type I binding spectrum with a Kd of 0.4 microM [2].
• This supports studies of contact dermatitis which have suggested abietic and dehydroabietic acid oxidants to be the cause of colophony induced allergic reactions [3].
• 16S rDNA sequence analysis showed that strain DhA-71, a dehydroabietic acid-degrading bacterium, was the nearest phylogenetic neighbour and that both strains should be placed as members of a newly created genus, Schlegelella gen. nov., in the Rubrivivax subgroup of the beta-Proteobacteria [4].
• Dehydroabietic acid accounts for a significant fraction of the effluent toxicity in the two ASBs studied [5].

High impact information on DEHYDROABIETIC ACID

• We also detected, by 16S rRNA gene PCR, four previously identified bacteria never reported in human infection, Alkanindiges illinoisensis, dehydroabietic acid-degrading bacterium DhA-73, unidentified Hailaer soda lake bacterium, and uncultured bacterium clone HuCa4 [6].
• Growth, induction, and substrate specificity of dehydroabietic acid-degrading bacteria isolated from a kraft mill effluent enrichment [7].
• Dehydroabietic acid, a major anionic contaminant of pulp mill effluent, reduces both active p-aminohippurate transport and passive membrane permeability in isolated renal membranes [8].
• Biotransformation of dehydroabietic acid with resting cell suspensions and calcium alginate-immobilized cells of Mortierella isabellina [9].
• One of these organisms, Pseudomonas abietaniphila BKME-9, harbors a convergent pathway that channels the nonaromatic abietanes and dehydroabietic acid into 7-oxodehydroabietic acid [10].

Biological context of DEHYDROABIETIC ACID

• We found that both low- and high-pH stresses (pH 3 and 10, respectively) decreased the removal of total organic carbon and completely inhibited the removal of DhA by the biomass of an aerated lagoon treating pulp mill effluent [11].
• Combined effects of pulp and paper effluent, dehydroabietic acid, and hypoxia on swimming performance, metabolism, and hematology of rainbow trout [12].
• Bioavailability of benzo(a)pyrene and dehydroabietic acid from a few lake waters containing varying dissolved organic carbon concentrations to Daphnia magna [13].
• Metabolic effects of dehydroabietic acid on rainbow trout erythrocytes [14].
• Oxygen consumption and ATP concentration were measured in rainbow trout erythrocytes incubated in a physiological saline containing 0, 5, 15, 30 or 60 mg/l dehydroabietic acid [14].

Anatomical context of DEHYDROABIETIC ACID

• Effects of dehydroabietic acid on the erythrocyte membrane [15].
• A significant increase in LPO was observed after 6h exposure to DHAA, in either mussel gills or hepatopancreas [16].
• Bile accumulation in hepatocytes after BaP treatment, cytoplasmic vacuolization and cell atrophy following DHAA exposure, as well as liver loss of parenchymal cells in BKPME-exposed fish, were also detected [17].
• The synthesized monomer compounds of hexahydrodibenzazepinone derivatives, which can be derived from dehydroabietic acid, were subjected to electrophysiological patch-clamp studies, followed by Magnus contraction-relaxation assay using rabbit urinary bladder smooth muscle strips to assess overall activities [18].
• Neutralizing effect of zinc oxide on dehydroabietic acid-induced toxicity on human polymorphonuclear leukocytes [19].

Associations of DEHYDROABIETIC ACID with other chemical compounds

• Effects of dehydroabietic acid and abietic acid on survival, reproduction, and growth of the crustacean Daphnia magna [20].
• A novel compound, 1 beta-hydroxydehydroabietic acid has been obtained by the microbial transformation of dehydroabietic acid, using cultures of Fusarium oxysporum and F. moniliforme [21].
• All the high concentration organic tracers, including levoglucosan and dehydroabietic acid, were characteristic for biomass burning [22].
• 9 oxidation products of abietic acid, dehydroabietic acid, and levopimaric acid were prepared synthetically to determine their sensitizing potential in guinea pigs [23].
• Juvenile sea bass were exposed for 6 h to 0 (control) and 0.0125 microM concentrations of the resin acids (RAs) abietic acid (AA) and dehydroabietic acid (DHAA) or 7-isopropyl-1-methylphenanthrene (retene) (Experiment 1) [24].

Gene context of DEHYDROABIETIC ACID

• DHAA and AA were detected at 4.3 and 6.3 men with ultraviolet detection at wavelength 200 and 239 nm, respectively [25].
• Due to its previously established toxicity, dehydroabietic acid may be a factor associated with virulence of S. typhimurium [26].
• Occurrence of the toxin dehydroabietic acid in Salmonella typhimurium [26].
• Dehydroabietic acid-induced depolarisation and release of neurotransmitters are not influenced by tetrodotoxin and are associated with only marginal inhibition of membrane-associated ATPase activity [27].

Analytical, diagnostic and therapeutic context of DEHYDROABIETIC ACID

• A peroxide of dehydroabietic acid was isolated from rosin using flash chromatography and preparative HPLC [28].
• One single intraperitoneal injection of abietic acid (AA) or dehydroabietic acid (DHAA), at the same molar dose (14.7 micromol/kg), was given and fish were examined 3 days later [29].
• The cytotoxic effect of dehydroabietic acid (DHAA), a resin acid found in rosin, was studied on human polymorphonuclear leukocytes using leakage of 51Cr from prelabeled cells, supravital staining, and transmission electron microscopy [19].
• Dehydroabietic acid derivatives have been reported to display antisecretory and antipepsin effect in animal models [30].

References