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Chemical Compound Review

Sylvic acid     (1R,4aR)-1,4a-dimethyl-7- propan-2-yl-2,3,4...

Synonyms: AC1NSWV5, SureCN678976, Rosin Acid, STL281965, ABIETIC ACID, PRACT, ...
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Disease relevance of ABIETIC ACID


High impact information on ABIETIC ACID


Biological context of ABIETIC ACID


Anatomical context of ABIETIC ACID


Associations of ABIETIC ACID with other chemical compounds

  • To determine if plicatic acid from cedar wood and abietic acid from pine resin could directly damage lung cells, we exposed monolayers of rat type II and human A549 alveolar epithelial cells, intact rat lungs, and rat tracheal explants to solutions of plicatic and abietic acids [7].
  • Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis [14].
  • To investigate whether esterification of rosin with polyalcohols changes its allergenic potential, abietic acid, the main component of rosin, was esterified with glycerol at high temperature [15].
  • The technique, using HPLC, is based on the analysis of abietic acid and dehydroabietic acid, major components of rosin [16].
  • The major product formed was isolated and identified, using nuclear magnetic resonance (NMR), infra-red (IR) and mass spectrometry (MS) analyses, as glyceryl triabietate (GTA), an ester between one glycerol molecule and 3 abietic acid molecules [15].

Gene context of ABIETIC ACID


Analytical, diagnostic and therapeutic context of ABIETIC ACID


  1. Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. Sadhra, S., Foulds, I.S., Gray, C.N. Br. J. Dermatol. (1996) [Pubmed]
  2. Wood-derived estrogens: studies in vitro with breast cancer cell lines and in vivo in trout. Mellanen, P., Petänen, T., Lehtimäki, J., Mäkelä, S., Bylund, G., Holmbom, B., Mannila, E., Oikari, A., Santti, R. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  3. Contact urticaria from abietic acid. el Sayed, F., Manzur, F., Bayle, P., Marguery, M.S., Bazex, J. Contact Derm. (1995) [Pubmed]
  4. The use of laboratory methods in contact dermatitis induced by composite materials. Ayala, F., Lembo, G., Balato, N., Patruno, C., Scognamiglio, G., Strazzullo, G., de Stefano, S. Contact Derm. (1990) [Pubmed]
  5. Abietic acid inhibits lipoxygenase activity. Ulusu, N.N., Ercil, D., Sakar, M.K., Tezcan, E.F. Phytotherapy research : PTR. (2002) [Pubmed]
  6. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Imaizumi, Y., Sakamoto, K., Yamada, A., Hotta, A., Ohya, S., Muraki, K., Uchiyama, M., Ohwada, T. Mol. Pharmacol. (2002) [Pubmed]
  7. The toxicity of constituents of cedar and pine woods to pulmonary epithelium. Ayars, G.H., Altman, L.C., Frazier, C.E., Chi, E.Y. J. Allergy Clin. Immunol. (1989) [Pubmed]
  8. Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. Takahashi, N., Kawada, T., Goto, T., Kim, C.S., Taimatsu, A., Egawa, K., Yamamoto, T., Jisaka, M., Nishimura, K., Yokota, K., Yu, R., Fushiki, T. FEBS Lett. (2003) [Pubmed]
  9. Inhibition of pure cultures of methanogens by benzene ring compounds. Patel, G.B., Agnew, B.J., Dicaire, C.J. Appl. Environ. Microbiol. (1991) [Pubmed]
  10. Diterpenoid resin acid biosynthesis in conifers: enzymatic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid. LaFever, R.E., Vogel, B.S., Croteau, R. Arch. Biochem. Biophys. (1994) [Pubmed]
  11. Hydrogenation reduces the allergenicity of colophony (rosin). Karlberg, A.T., Boman, A., Nilsson, J.L. Contact Derm. (1988) [Pubmed]
  12. Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products. Yoshida, N., Koizumi, M., Adachi, I., Kawakami, J. Food Chem. Toxicol. (2006) [Pubmed]
  13. The interaction of abietic acid with phospholipid membranes. Aranda, F.J., Villalaín, J. Biochim. Biophys. Acta (1997) [Pubmed]
  14. Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. Funk, C., Croteau, R. Arch. Biochem. Biophys. (1994) [Pubmed]
  15. The allergenicity of glycerol esters and other esters of rosin (colophony). Shao, L.P., Gäfvert, E., Karlberg, A.T., Nilsson, U., Nilsson, J.L. Contact Derm. (1993) [Pubmed]
  16. Detection of rosin (colophony) components in technical products using an HPLC technique. Ehrin, E., Karlberg, A.T. Contact Derm. (1990) [Pubmed]
  17. Antioxidant activity of a catechol derived from abietic acid. Justino, G.C., Correia, C.F., Mira, L., Borges Dos Santos, R.M., Martinho Simões, J.A., Silva, A.M., Santos, C., Gigante, B. J. Agric. Food Chem. (2006) [Pubmed]
  18. Rosin (colophony) and zinc oxide in adhesive bandages. An appropriate combination for rosin-sensitive patients? Gäfvert, E., Färm, G. Contact Derm. (1995) [Pubmed]
  19. Sampling and analysis of airborne resin acids and solvent-soluble material derived from heated colophony (rosin) flux: a method to quantify exposure to sensitizing compounds liberated during electronics soldering. Smith, P.A., Son, P.S., Callaghan, P.M., Jederberg, W.W., Kuhlmann, K., Still, K.R. Toxicology (1996) [Pubmed]
  20. Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. Fernández, M.A., Tornos, M.P., García, M.D., de las Heras, B., Villar, A.M., Sáenz, M.T. J. Pharm. Pharmacol. (2001) [Pubmed]
  21. Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus. Smith, E., Williamson, E., Zloh, M., Gibbons, S. Phytotherapy research : PTR. (2005) [Pubmed]
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