Disease relevance of C07912

• We report a case of tetrahydrozoline ingestion in which, paradoxically, lethargy, bradycardia, and hypotension were noted [1].
• Pediatric Visine (tetrahydrozoline) ingestion: case report and review of imidazoline toxicity [2].
• We present a case of tetrahydrozoline ingestion in an adult who presented with chest pain, bradycardia, mental status depression, miosis, and other signs and symptoms of imidazole compound poisoning [3].

High impact information on C07912

• On guinea-pig atria, tetrahydrozoline and tolazoline produced positive chronotropic effects which were not influenced by reserpine and cocaine treatment, or treatment with a beta adrenoceptor blocker, propranolol [4].
• METHODS: We determined the in vitro epidermal flux of ephedrine, naphazoline, oxymetazoline, phenylephrine, and xylometazoline applied as saturated solutions in propylene glycol:water (1:1) and of ephedrine, naphazoline and tetrahydrozoline as 10% solutions of 1:1 molar ratio ion-pairs with SA in liquid paraffin [5].
• The maximum tolazoline-induced change in heart rate was 2.5-3.0 times greater than tetrahydrozoline's, in distinct contrast to their identical effect at 30 degrees C. All other responses to the two drugs were the same at 30 and 37 degrees C. Our results suggest that tolazoline and tetrahydrozoline directly stimulate histamine H2-receptors [6].
• Formulations based on the ternary systems TZ/G/HA, TZ/HCS/HA, TZ/G/PAA and TZ/HCS/PAA at the stoichiometry ratios between cationic and anionic polymers and containing a 10 and 20 fold excess of the anionic polymers were prepared [7].
• Naphazoline, tetrahydrozoline and para-aminoclonidine did not produce significant contraction of the blood vessel but did antagonize the action of the agonists [8].

Anatomical context of C07912

• RESULTS: Twenty-five percent aluminum chloride produced a significantly greater extent of cellular damage than 0.05% tetrahydrozoline, which caused only mild changes in the cultured cells [9].
• Sinoatrial node arrest following tetrahydrozoline ingestion [10].
• The ratio of the connective tissue area to that of the inflammatory infiltrate showed that 25% aluminum chloride (Racestyptine) was the most aggressive and tetrahydrozoline the least aggressive retraction agent used [11].

Associations of C07912 with other chemical compounds

• The HPLC system is so designed that a variety of ophthalmic solutions containing either naphazoline or tetrahydrozoline can be analyzed concomitantly [12].
• Sixteen subjects were fit with Cibasoft clear daily wear contact lenses and were asked to use two drops of tetrahydrozoline (Visine) twice a day for 4 months on one eye [13].
• Determination of tetrahydrozoline hydrochloride and fluorometholone in pharmaceutical formulations by HPLC and derivative UV spectrophotometry [14].
• Simultaneous determination of ofloxacin, tetrahydrozoline hydrochloride, and prednisolone acetate by high-performance liquid chromatography [15].
• Simple HPLC determination of benzalkonium chloride in ophthalmic formulations containing antazoline and tetrahydrozoline [16].

Analytical, diagnostic and therapeutic context of C07912

• After treating 1 group of specimens with 0.05% tetrahydrozoline and another group with 25% aluminum chloride, both for 10 minutes, the cultured cells were examined with scanning and transmission electron microscopy and compared with control specimens [9].

References