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Chemical Compound Review

naphazoline     2-(naphthalen-1-ylmethyl)- 4,5-dihydro-1H...

Synonyms: Clearine, Nafazolin, Nafazolina, Nafazoline, Antan, ...
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Disease relevance of IMIDAN


Psychiatry related information on IMIDAN


High impact information on IMIDAN


Chemical compound and disease context of IMIDAN


Biological context of IMIDAN


Anatomical context of IMIDAN


Associations of IMIDAN with other chemical compounds


Gene context of IMIDAN

  • Only naphazoline retained its whitening ability after ten days (Part II) [23].
  • Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml-1 and a relative standard deviation of 3.74% at the 500 ng ml-1 level [26].
  • It is suggested that i.v. clonidine and naphazoline reduce renin release through activation of alpha-adrenoceptors within the kidney [27].

Analytical, diagnostic and therapeutic context of IMIDAN


  1. Phototoxicity of naphazoline. Evidence that hydrated electrons, nitrogen-centered radicals, and OH radicals trigger DNA damage: a combined photocleavage and laser flash photolysis study. Sortino, S., Giuffrida, S., Scaiano, J.C. Chem. Res. Toxicol. (1999) [Pubmed]
  2. Effects of Vasocon-A in the allergen challenge model of acute allergic conjunctivitis. Abelson, M.B., Paradis, A., George, M.A., Smith, L.M., Maguire, L., Burns, R. Arch. Ophthalmol. (1990) [Pubmed]
  3. Acute and chronic conjunctivitis due to over-the-counter ophthalmic decongestants. Soparkar, C.N., Wilhelmus, K.R., Koch, D.D., Wallace, G.W., Jones, D.B. Arch. Ophthalmol. (1997) [Pubmed]
  4. Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors. Ogidigben, M.J., Chu, T.C., Potter, D.E. Exp. Eye Res. (2001) [Pubmed]
  5. Severe arterial hypertension caused by chronical abuse of a topical mineralocorticoid. Armbruster, H., Vetter, W., Reck, G., Beckerhoff, R., Siegenthaler, W. International journal of clinical pharmacology and biopharmacy. (1975) [Pubmed]
  6. Central alpha 2-adrenergic control of the pattern of small intestinal motility in rats. Fargeas, M.J., Fioramonti, J., Bueno, L. Gastroenterology (1986) [Pubmed]
  7. Two examples of rapid and simple drug analysis in pharmaceutical formulations using capillary electrophoresis: naphazoline, dexamethasone and benzalkonium in nose drops and nystatin in an oily suspension. Raith, K., Althoff, E., Banse, J., Neidhardt, H., Neubert, R.H. Electrophoresis (1998) [Pubmed]
  8. Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues. Amemiya, Y., Hong, S.S., Venkataraman, B.V., Patil, P.N., Shams, G., Romstedt, K., Feller, D.R., Hsu, F.L., Miller, D.D. J. Med. Chem. (1992) [Pubmed]
  9. Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction. Hrometz, S.L., Edelmann, S.E., McCune, D.F., Olges, J.R., Hadley, R.W., Perez, D.M., Piascik, M.T. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  10. Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. Piletz, J.E., Zhu, H., Chikkala, D.N. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  11. Central action of narcotic analgesics. Part IV. Noradrenergic influences on the activity of analgesics in rats. Malec, D., Grabowska, E., Langwiński, R. Polish journal of pharmacology and pharmacy. (1978) [Pubmed]
  12. Oxymetazoline ophthalmic solution versus naphazoline solution in non-infectious conjunctivitis. Rybiczka, R., Mauracher, E. Pharmatherapeutica. (1983) [Pubmed]
  13. Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets. Venkataraman, B.V., Shams, G., Hamada, A., Amemiya, Y., Tantishaiyakul, V., Hsu, F., Fashempour, J., Romstedt, K.J., Miller, D.D., Feller, D.R. Naunyn Schmiedebergs Arch. Pharmacol. (1991) [Pubmed]
  14. Topical naphazoline in treatment of myopathic ptosis. Uncini, A., De Nicola, G., Di Muzio, A., Rancitelli, G., Colangelo, L., Gambi, D., Gallenga, P.E. Acta neurologica Scandinavica. (1993) [Pubmed]
  15. Effects of biogenic amines and adrenergic drugs on oviposition in the cattle tick Boophilus: evidence for octopaminergic innervation of the oviduct. Booth, T.F. Exp. Appl. Acarol. (1989) [Pubmed]
  16. Clonidine-specific antibodies as models for imidazole and alpha 2-adrenergic receptor binding sites: implications for the structure of clonidine-displacing substance. Meeley, M.P., Ernsberger, P., McCauley, P.M., Reis, D.J. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. (1988) [Pubmed]
  17. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. Carpéné, C., Collon, P., Remaury, A., Cordi, A., Hudson, A., Nutt, D., Lafontan, M. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  18. Dipivefrin reduces blood flow in the ciliary body in humans. Michelson, G., Groh, M.J. Ophthalmology (1994) [Pubmed]
  19. Effects of cromakalim (BRL 34915) on mechanical responses of rat vas deferens to noradrenaline and naphazoline. Grana, E., Barbieri, A., Zonta, F. Eur. J. Pharmacol. (1991) [Pubmed]
  20. Frequency-dependence of the positive inotropic effect of methoxamine and naphazoline mediated by alpha-Adrenoceptors in the isolated rabbit papillary muscle. Endoh, M., Schümann, H.J. Naunyn Schmiedebergs Arch. Pharmacol. (1975) [Pubmed]
  21. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. Yamaguchi, I., Hiroi, J., Kumada, S. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  22. A study of the central effects of sympathomimetic drugs: EEG and behavioural investigations on clonidine and naphazoline. Florio, V., Bianchi, L., Lonogo, V.G. Neuropharmacology (1975) [Pubmed]
  23. Tolerance and absence of rebound vasodilation following topical ocular decongestant usage. Abelson, M.B., Butrus, S.I., Weston, J.H., Rosner, B. Ophthalmology (1984) [Pubmed]
  24. Synthesis and identification of the primary degradation product in a commercial ophthalmic formulation using NMR, MS, and a stability-indicating HPLC method for antazoline and naphazoline. Ruckmick, S.C., Marsh, D.F., Duong, S.T. Journal of pharmaceutical sciences. (1995) [Pubmed]
  25. Inhibition by glibenclamide of the effects of cromakalim on responses of rat vas deferens to naphazoline. Grana, E., Barbieri, A., Zonta, F. Eur. J. Pharmacol. (1991) [Pubmed]
  26. Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations. Segura Carretero, A., Cruces Blanco, C., Cañabate Díaz, B., Fernández Gutiérrez, A. The Analyst. (1998) [Pubmed]
  27. Mechanism of inhibition of renin release by clonidine in rats. Chevillard, C., Pasquier, R., Duchene, N., Alexandre, J.M. Eur. J. Pharmacol. (1978) [Pubmed]
  28. High-performance liquid chromatographic stability-indicating assay for naphazoline and tetrahydrozoline in ophthalmic preparations. Bauer, J., Krogh, S. Journal of pharmaceutical sciences. (1983) [Pubmed]
  29. Prolonged awakening and pulmonary edema after general anesthesia and naphazoline application in an infant. Stamer, U.M., Buderus, S., Wetegrove, S., Lentze, M.J., Stüber, F. Anesth. Analg. (2001) [Pubmed]
  30. Supersensitivity of analgesic responses to alpha 2-adrenergic agonists in genetically hypertensive rats. Marwaha, J. Brain Res. (1984) [Pubmed]
  31. Determination of naphazoline in rat plasma using column liquid chromatography with ultraviolet detection. Chabenat, C., Boucly, P. Biomed. Chromatogr. (1992) [Pubmed]
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